lcl161 Search Results


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A list of prominent SMAC mimetics, their indications for therapeutic strategies in specific cancers, suggested combinatorial approaches and clinical trials conducted to date [ <xref ref-type= 39 – 91 , 93 108 ]" width="250" height="auto" />
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Image Search Results


A list of prominent SMAC mimetics, their indications for therapeutic strategies in specific cancers, suggested combinatorial approaches and clinical trials conducted to date [ <xref ref-type= 39 – 91 , 93 108 ]" width="100%" height="100%">

Journal: Apoptosis

Article Title: Overcoming chemotherapy drug resistance by targeting inhibitors of apoptosis proteins (IAPs)

doi: 10.1007/s10495-017-1375-1

Figure Lengend Snippet: A list of prominent SMAC mimetics, their indications for therapeutic strategies in specific cancers, suggested combinatorial approaches and clinical trials conducted to date [ 39 91 , 93 108 ]

Article Snippet: Examples of compounds in development that target XIAP include SM-12d, Compound 21, AT-406 (Ascenta Therapeutics), LCL-161 (Novartis Pharmaceuticals), GDC-0152 (Genentech), GDC-0197 (Genentech), SM-164, Birinapant/ TL32711 (Tetralogic Pharmaceuticals), HGS1029, LBW-242, Compound 10 (Aegera Therapeutics), Compound 24 (Allist Pharmaceuticals) and Compound 1A (Genentech).

Techniques: Clinical Proteomics, In Vitro, Inhibition, Expressing