ku57788 Search Results


nu 7441  (MedChemExpress)
93
MedChemExpress nu 7441
Nu 7441, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 93 stars, based on 1 article reviews
nu 7441 - by Bioz Stars, 2026-03
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ku  (TargetMol)
99
TargetMol ku
Ku, supplied by TargetMol, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 99 stars, based on 1 article reviews
ku - by Bioz Stars, 2026-03
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ku-57788  (ApexBio)
90
ApexBio ku-57788
Ku 57788, supplied by ApexBio, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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ku-57788 - by Bioz Stars, 2026-03
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ku57788  (Stratech Scientific Ltd)
90
Stratech Scientific Ltd ku57788
Spider plots showing STAT1 ( A ) and STAT3 ( B ) pTyr701 (red line) and pSer727 (blue line) MFI normalized to HyIL-6-treated cells in the presence of different inhibitors in human primary CD4 + Th1 cells. C) Effect of different mTOR inhibitors on the STAT1 (upper panel) and STAT3 (lower panel) Ser727 phosphorylation induced by HyIL-6 in human primary CD4 + T cells. D) Effect of ATM inhibitor (KU53933) and DNA-PK inhibitor <t>(KU57788)</t> on the STAT1 (upper panel) and STAT3 (lower panel) Ser727 phosphorylation induced by HyIL-6 in human primary CD4 + T cells. E) Effect of different CDK inhibitors on the STAT3 Tyr705 (left panel) and STAT3 Ser727 (right panel) phosphorylation induced by HyIL-6 in human primary CD4 + T cells. F) Immunoblotting analysis of the cytoplasmic and nuclear fractions of human primary CD4 + Th1 cells stimulated with HyIL-6 for the times indicated. Quantitative analysis showing the combined data of three individual biological replicas are shown alongside. G) Time-course of STAT3 Tyr705 phosphorylation in nuclear fraction of human primary CD4 + cells stimulated with HyIL-6 in the absence (blue line) or presence (red line) of 2μM Flavopiridol. Quantitative analysis showing the normalized data of three independent biological samples is shown alongside. Error bars show mean + SEM.
Ku57788, supplied by Stratech Scientific Ltd, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/ku57788/product/Stratech Scientific Ltd
Average 90 stars, based on 1 article reviews
ku57788 - by Bioz Stars, 2026-03
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dna-pk inhibitor ku57788  (AstraZeneca ltd)
90
AstraZeneca ltd dna-pk inhibitor ku57788
Spider plots showing STAT1 ( A ) and STAT3 ( B ) pTyr701 (red line) and pSer727 (blue line) MFI normalized to HyIL-6-treated cells in the presence of different inhibitors in human primary CD4 + Th1 cells. C) Effect of different mTOR inhibitors on the STAT1 (upper panel) and STAT3 (lower panel) Ser727 phosphorylation induced by HyIL-6 in human primary CD4 + T cells. D) Effect of ATM inhibitor (KU53933) and DNA-PK inhibitor <t>(KU57788)</t> on the STAT1 (upper panel) and STAT3 (lower panel) Ser727 phosphorylation induced by HyIL-6 in human primary CD4 + T cells. E) Effect of different CDK inhibitors on the STAT3 Tyr705 (left panel) and STAT3 Ser727 (right panel) phosphorylation induced by HyIL-6 in human primary CD4 + T cells. F) Immunoblotting analysis of the cytoplasmic and nuclear fractions of human primary CD4 + Th1 cells stimulated with HyIL-6 for the times indicated. Quantitative analysis showing the combined data of three individual biological replicas are shown alongside. G) Time-course of STAT3 Tyr705 phosphorylation in nuclear fraction of human primary CD4 + cells stimulated with HyIL-6 in the absence (blue line) or presence (red line) of 2μM Flavopiridol. Quantitative analysis showing the normalized data of three independent biological samples is shown alongside. Error bars show mean + SEM.
Dna Pk Inhibitor Ku57788, supplied by AstraZeneca ltd, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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dna-pk inhibitor ku57788 - by Bioz Stars, 2026-03
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ku-57788  (Kudos Pharmaceuticals)
90
Kudos Pharmaceuticals ku-57788
Spider plots showing STAT1 ( A ) and STAT3 ( B ) pTyr701 (red line) and pSer727 (blue line) MFI normalized to HyIL-6-treated cells in the presence of different inhibitors in human primary CD4 + Th1 cells. C) Effect of different mTOR inhibitors on the STAT1 (upper panel) and STAT3 (lower panel) Ser727 phosphorylation induced by HyIL-6 in human primary CD4 + T cells. D) Effect of ATM inhibitor (KU53933) and DNA-PK inhibitor <t>(KU57788)</t> on the STAT1 (upper panel) and STAT3 (lower panel) Ser727 phosphorylation induced by HyIL-6 in human primary CD4 + T cells. E) Effect of different CDK inhibitors on the STAT3 Tyr705 (left panel) and STAT3 Ser727 (right panel) phosphorylation induced by HyIL-6 in human primary CD4 + T cells. F) Immunoblotting analysis of the cytoplasmic and nuclear fractions of human primary CD4 + Th1 cells stimulated with HyIL-6 for the times indicated. Quantitative analysis showing the combined data of three individual biological replicas are shown alongside. G) Time-course of STAT3 Tyr705 phosphorylation in nuclear fraction of human primary CD4 + cells stimulated with HyIL-6 in the absence (blue line) or presence (red line) of 2μM Flavopiridol. Quantitative analysis showing the normalized data of three independent biological samples is shown alongside. Error bars show mean + SEM.
Ku 57788, supplied by Kudos Pharmaceuticals, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/ku-57788/product/Kudos Pharmaceuticals
Average 90 stars, based on 1 article reviews
ku-57788 - by Bioz Stars, 2026-03
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dna-pkcs-specific inhibitor ku57788  (Axon Medchem LLC)
90
Axon Medchem LLC dna-pkcs-specific inhibitor ku57788
Spider plots showing STAT1 ( A ) and STAT3 ( B ) pTyr701 (red line) and pSer727 (blue line) MFI normalized to HyIL-6-treated cells in the presence of different inhibitors in human primary CD4 + Th1 cells. C) Effect of different mTOR inhibitors on the STAT1 (upper panel) and STAT3 (lower panel) Ser727 phosphorylation induced by HyIL-6 in human primary CD4 + T cells. D) Effect of ATM inhibitor (KU53933) and DNA-PK inhibitor <t>(KU57788)</t> on the STAT1 (upper panel) and STAT3 (lower panel) Ser727 phosphorylation induced by HyIL-6 in human primary CD4 + T cells. E) Effect of different CDK inhibitors on the STAT3 Tyr705 (left panel) and STAT3 Ser727 (right panel) phosphorylation induced by HyIL-6 in human primary CD4 + T cells. F) Immunoblotting analysis of the cytoplasmic and nuclear fractions of human primary CD4 + Th1 cells stimulated with HyIL-6 for the times indicated. Quantitative analysis showing the combined data of three individual biological replicas are shown alongside. G) Time-course of STAT3 Tyr705 phosphorylation in nuclear fraction of human primary CD4 + cells stimulated with HyIL-6 in the absence (blue line) or presence (red line) of 2μM Flavopiridol. Quantitative analysis showing the normalized data of three independent biological samples is shown alongside. Error bars show mean + SEM.
Dna Pkcs Specific Inhibitor Ku57788, supplied by Axon Medchem LLC, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/dna-pkcs-specific inhibitor ku57788/product/Axon Medchem LLC
Average 90 stars, based on 1 article reviews
dna-pkcs-specific inhibitor ku57788 - by Bioz Stars, 2026-03
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ku-57788  (AK Scientific)
90
AK Scientific ku-57788
Spider plots showing STAT1 ( A ) and STAT3 ( B ) pTyr701 (red line) and pSer727 (blue line) MFI normalized to HyIL-6-treated cells in the presence of different inhibitors in human primary CD4 + Th1 cells. C) Effect of different mTOR inhibitors on the STAT1 (upper panel) and STAT3 (lower panel) Ser727 phosphorylation induced by HyIL-6 in human primary CD4 + T cells. D) Effect of ATM inhibitor (KU53933) and DNA-PK inhibitor <t>(KU57788)</t> on the STAT1 (upper panel) and STAT3 (lower panel) Ser727 phosphorylation induced by HyIL-6 in human primary CD4 + T cells. E) Effect of different CDK inhibitors on the STAT3 Tyr705 (left panel) and STAT3 Ser727 (right panel) phosphorylation induced by HyIL-6 in human primary CD4 + T cells. F) Immunoblotting analysis of the cytoplasmic and nuclear fractions of human primary CD4 + Th1 cells stimulated with HyIL-6 for the times indicated. Quantitative analysis showing the combined data of three individual biological replicas are shown alongside. G) Time-course of STAT3 Tyr705 phosphorylation in nuclear fraction of human primary CD4 + cells stimulated with HyIL-6 in the absence (blue line) or presence (red line) of 2μM Flavopiridol. Quantitative analysis showing the normalized data of three independent biological samples is shown alongside. Error bars show mean + SEM.
Ku 57788, supplied by AK Scientific, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/ku-57788/product/AK Scientific
Average 90 stars, based on 1 article reviews
ku-57788 - by Bioz Stars, 2026-03
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Image Search Results


Spider plots showing STAT1 ( A ) and STAT3 ( B ) pTyr701 (red line) and pSer727 (blue line) MFI normalized to HyIL-6-treated cells in the presence of different inhibitors in human primary CD4 + Th1 cells. C) Effect of different mTOR inhibitors on the STAT1 (upper panel) and STAT3 (lower panel) Ser727 phosphorylation induced by HyIL-6 in human primary CD4 + T cells. D) Effect of ATM inhibitor (KU53933) and DNA-PK inhibitor (KU57788) on the STAT1 (upper panel) and STAT3 (lower panel) Ser727 phosphorylation induced by HyIL-6 in human primary CD4 + T cells. E) Effect of different CDK inhibitors on the STAT3 Tyr705 (left panel) and STAT3 Ser727 (right panel) phosphorylation induced by HyIL-6 in human primary CD4 + T cells. F) Immunoblotting analysis of the cytoplasmic and nuclear fractions of human primary CD4 + Th1 cells stimulated with HyIL-6 for the times indicated. Quantitative analysis showing the combined data of three individual biological replicas are shown alongside. G) Time-course of STAT3 Tyr705 phosphorylation in nuclear fraction of human primary CD4 + cells stimulated with HyIL-6 in the absence (blue line) or presence (red line) of 2μM Flavopiridol. Quantitative analysis showing the normalized data of three independent biological samples is shown alongside. Error bars show mean + SEM.

Journal: bioRxiv

Article Title: CDK8 fine-tunes IL-6 transcriptional activities by limiting STAT3 resident time at the gene loci

doi: 10.1101/2020.03.19.998351

Figure Lengend Snippet: Spider plots showing STAT1 ( A ) and STAT3 ( B ) pTyr701 (red line) and pSer727 (blue line) MFI normalized to HyIL-6-treated cells in the presence of different inhibitors in human primary CD4 + Th1 cells. C) Effect of different mTOR inhibitors on the STAT1 (upper panel) and STAT3 (lower panel) Ser727 phosphorylation induced by HyIL-6 in human primary CD4 + T cells. D) Effect of ATM inhibitor (KU53933) and DNA-PK inhibitor (KU57788) on the STAT1 (upper panel) and STAT3 (lower panel) Ser727 phosphorylation induced by HyIL-6 in human primary CD4 + T cells. E) Effect of different CDK inhibitors on the STAT3 Tyr705 (left panel) and STAT3 Ser727 (right panel) phosphorylation induced by HyIL-6 in human primary CD4 + T cells. F) Immunoblotting analysis of the cytoplasmic and nuclear fractions of human primary CD4 + Th1 cells stimulated with HyIL-6 for the times indicated. Quantitative analysis showing the combined data of three individual biological replicas are shown alongside. G) Time-course of STAT3 Tyr705 phosphorylation in nuclear fraction of human primary CD4 + cells stimulated with HyIL-6 in the absence (blue line) or presence (red line) of 2μM Flavopiridol. Quantitative analysis showing the normalized data of three independent biological samples is shown alongside. Error bars show mean + SEM.

Article Snippet: Then, cells were starved of IL2 for 24 hours before stimulation with 10nM HyIL-6 in the presence or absence of different inhibitors [2μM Tofacitinib (Stratech, #S2789-SEL), 2μM Rapamycin (Stratech, #S1039-SEL), 2μM Torin1 (Tocris, #4247), 2μM CHIR-99021 (Stratech, #G09-901B-SGC), 2μM PD184352 (Stratech, #S1020-SEL), 2μM Roscovitine (Calbiochem, #557360), 2μM GDC0941 (abCam, #ab141352), 2μM PP2 (Stratech, #S7008-SEL), 2μM VX745 (Tocris, #3915), 2μM JAK inhibitor VII (Calbiochem, #796041-65-1), 2μM AX15836 (Tocris, #5843), 2μM AZD8055 (Stratech, #A8214-APE), 2μM KU0063794 (Tocris, #3725), 2μM KU55933 (Stratech, #A4605-APE), 2μM KU57788 (Stratech, #A8315-APE), 2μM CBI-2347 (a kind gift of Boehringer Ingelheim), 2uM MSC2530818 (Stratech, #S8387-SEL), 2μM CDK9 inhibitor II (Calbiochem, #140651-18-9), 2μM NVP2 (Tocris, #6535), 2μM THZ531 (Stratech, #A8736-APE), 2μM MFH-2-90-1 (a kind gift of Dr. Greg Findlay, University of Dundee, UK) and 2μM Flavopiridol (Stratech, #S2679-SEL)] as indicated.

Techniques: Western Blot