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Fig. 3 Macrophage-mediated inflammation in myocardium near the fibro-fatty tissues of ACM patients. A The mRNA expression of <t>CCL3</t> in RV myocardium from ACM patients and NC; (B) The IHC staining of CCL3 in RV myocardium from ACM patients and NC; (C) Opal multicolor IHC staining of CCL3, CD68, and DAPI in RV myocardium from ACM patients and NC; (D) The correlation between the mRNA level of CCL3 in RV myocardium and the level of saturated TGs in RV fibro-fatty tissue from ACM patients; (E) The correlation between the mRNA level of CCL3 and duration from initial symptom to HTx; (F) The correlation between the mRNA level of CCL3 and duration from heart failure to HTx. RV, right ventricle; ACM, arrhythmogenic cardiomyopathy; NC, normal control; HTx, heart transplantation
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Fig. 3 Macrophage-mediated inflammation in myocardium near the fibro-fatty tissues of ACM patients. A The mRNA expression of CCL3 in RV myocardium from ACM patients and NC; (B) The IHC staining of CCL3 in RV myocardium from ACM patients and NC; (C) Opal multicolor IHC staining of CCL3, CD68, and DAPI in RV myocardium from ACM patients and NC; (D) The correlation between the mRNA level of CCL3 in RV myocardium and the level of saturated TGs in RV fibro-fatty tissue from ACM patients; (E) The correlation between the mRNA level of CCL3 and duration from initial symptom to HTx; (F) The correlation between the mRNA level of CCL3 and duration from heart failure to HTx. RV, right ventricle; ACM, arrhythmogenic cardiomyopathy; NC, normal control; HTx, heart transplantation

Journal: BMC medicine

Article Title: Plasma CCL3 predicts adverse heart failure outcomes in patients with arrhythmogenic cardiomyopathy.

doi: 10.1186/s12916-025-04024-y

Figure Lengend Snippet: Fig. 3 Macrophage-mediated inflammation in myocardium near the fibro-fatty tissues of ACM patients. A The mRNA expression of CCL3 in RV myocardium from ACM patients and NC; (B) The IHC staining of CCL3 in RV myocardium from ACM patients and NC; (C) Opal multicolor IHC staining of CCL3, CD68, and DAPI in RV myocardium from ACM patients and NC; (D) The correlation between the mRNA level of CCL3 in RV myocardium and the level of saturated TGs in RV fibro-fatty tissue from ACM patients; (E) The correlation between the mRNA level of CCL3 and duration from initial symptom to HTx; (F) The correlation between the mRNA level of CCL3 and duration from heart failure to HTx. RV, right ventricle; ACM, arrhythmogenic cardiomyopathy; NC, normal control; HTx, heart transplantation

Article Snippet: The concentrations of CCL3 in plasma were quantified using a commercial kit (Proteintech, KE00092).

Techniques: Expressing, Immunohistochemistry, Control, Transplantation Assay