kdm3b Search Results


gene exp kdm3b mm00804683 m1  (Thermo Fisher)
91
Thermo Fisher gene exp kdm3b mm00804683 m1
Gene Exp Kdm3b Mm00804683 M1, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 91/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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kdm3b  (Proteintech)
93
Proteintech kdm3b
Figure 1. <t>Kdm3b</t> plays an important role in reprogramming to pluripotency.
Kdm3b, supplied by Proteintech, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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1 650 bac us kdm3b jmjd1b bric 842 1761 bac kdm4a  (BPS Bioscience)
86
BPS Bioscience 1 650 bac us kdm3b jmjd1b bric 842 1761 bac kdm4a
Figure 1. <t>Kdm3b</t> plays an important role in reprogramming to pluripotency.
1 650 Bac Us Kdm3b Jmjd1b Bric 842 1761 Bac Kdm4a, supplied by BPS Bioscience, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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wt and kdm3b ko k562 cells  (Shanghai Genechem Ltd)
90
Shanghai Genechem Ltd wt and kdm3b ko k562 cells
Figure 1. <t>Kdm3b</t> plays an important role in reprogramming to pluripotency.
Wt And Kdm3b Ko K562 Cells, supplied by Shanghai Genechem Ltd, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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anti-kdm3b antibody gtx116198  (GeneTex)
90
GeneTex anti-kdm3b antibody gtx116198
Figure 1. <t>Kdm3b</t> plays an important role in reprogramming to pluripotency.
Anti Kdm3b Antibody Gtx116198, supplied by GeneTex, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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kdm3b sirna  (Qiagen)
90
Qiagen kdm3b sirna
The effect of <t>KDM3B</t> overexpression on the Erastin‐induced ferroptosis. (A) The effect of KDM3B in HT‐1080 cells on the ferroptosis induced by Erastin (5 μ m ) and RSL3 (2.5 μ m ). KDM3B stably overexpressed HT‐1080 was constructed as described in the materials and methods. Parental and KDM3B over cells were plated in 96‐well plates at a concentration of 1500 cells per well and incubated with indicated compounds 24 h after plating. Three days later, cells were collected for proliferation detection. (B) The effect of JMJD1C in 293 cells on the ferroptosis induced by Erastin (5 μ m ) and RSL3 (2.5 μ m ). JMJD1C stably overexpressed 293 was constructed as described in the materials and methods. Parental and JMJD1C over cells were plated in 96‐well plates at a concentration of 1500 cells per well and incubated with indicated compounds 24 h after plating. Three days later, cells were collected for proliferation detection. (C) The effect of KDM3B stable overexpression on the H3K9 monomethylation and dimethylation of HT‐1080 cells. Parental and KDM3B over HT‐1080 cells were collected and lysed for Western blot detection. H3 was used as endogenous control. (D) The effect of JMJD1C stable overexpression on the H3K9 monomethylation and dimethylation of 293 cells. Parental and JMJD1C over HT‐1080 cells were collected and lysed for Western blot detection. H3 was used as endogenous control. (E) The effect of KDM3B inhibitor JDI‐16 on Erastin‐induced repression of cell proliferation of THP‐1 cells. THP‐1 cells were plated in 96‐well round‐bottom plates at a concentration of 4000 cells per well and incubated with indicated compounds (Erastin, 5 μ m , JDI‐16, 12.5 μ m ) 24 h after plating. Four days later, cells were collected for proliferation detection. For (A, B, E), three independent experiments were performed, quantitative results are reported as mean ± SD, the statistical analysis was performed using Student's t ‐test, and P value smaller than 0.05 (represented by *) was regarded as statistically significant.
Kdm3b Sirna, supplied by Qiagen, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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kdm3b (h558a) point mutants  (Cosmo Genetech Co)
90
Cosmo Genetech Co kdm3b (h558a) point mutants
The effect of <t>KDM3B</t> overexpression on the Erastin‐induced ferroptosis. (A) The effect of KDM3B in HT‐1080 cells on the ferroptosis induced by Erastin (5 μ m ) and RSL3 (2.5 μ m ). KDM3B stably overexpressed HT‐1080 was constructed as described in the materials and methods. Parental and KDM3B over cells were plated in 96‐well plates at a concentration of 1500 cells per well and incubated with indicated compounds 24 h after plating. Three days later, cells were collected for proliferation detection. (B) The effect of JMJD1C in 293 cells on the ferroptosis induced by Erastin (5 μ m ) and RSL3 (2.5 μ m ). JMJD1C stably overexpressed 293 was constructed as described in the materials and methods. Parental and JMJD1C over cells were plated in 96‐well plates at a concentration of 1500 cells per well and incubated with indicated compounds 24 h after plating. Three days later, cells were collected for proliferation detection. (C) The effect of KDM3B stable overexpression on the H3K9 monomethylation and dimethylation of HT‐1080 cells. Parental and KDM3B over HT‐1080 cells were collected and lysed for Western blot detection. H3 was used as endogenous control. (D) The effect of JMJD1C stable overexpression on the H3K9 monomethylation and dimethylation of 293 cells. Parental and JMJD1C over HT‐1080 cells were collected and lysed for Western blot detection. H3 was used as endogenous control. (E) The effect of KDM3B inhibitor JDI‐16 on Erastin‐induced repression of cell proliferation of THP‐1 cells. THP‐1 cells were plated in 96‐well round‐bottom plates at a concentration of 4000 cells per well and incubated with indicated compounds (Erastin, 5 μ m , JDI‐16, 12.5 μ m ) 24 h after plating. Four days later, cells were collected for proliferation detection. For (A, B, E), three independent experiments were performed, quantitative results are reported as mean ± SD, the statistical analysis was performed using Student's t ‐test, and P value smaller than 0.05 (represented by *) was regarded as statistically significant.
Kdm3b (H558a) Point Mutants, supplied by Cosmo Genetech Co, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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gene exp kdm3b hs00213240 m1  (Thermo Fisher)
86
Thermo Fisher gene exp kdm3b hs00213240 m1
The effect of <t>KDM3B</t> overexpression on the Erastin‐induced ferroptosis. (A) The effect of KDM3B in HT‐1080 cells on the ferroptosis induced by Erastin (5 μ m ) and RSL3 (2.5 μ m ). KDM3B stably overexpressed HT‐1080 was constructed as described in the materials and methods. Parental and KDM3B over cells were plated in 96‐well plates at a concentration of 1500 cells per well and incubated with indicated compounds 24 h after plating. Three days later, cells were collected for proliferation detection. (B) The effect of JMJD1C in 293 cells on the ferroptosis induced by Erastin (5 μ m ) and RSL3 (2.5 μ m ). JMJD1C stably overexpressed 293 was constructed as described in the materials and methods. Parental and JMJD1C over cells were plated in 96‐well plates at a concentration of 1500 cells per well and incubated with indicated compounds 24 h after plating. Three days later, cells were collected for proliferation detection. (C) The effect of KDM3B stable overexpression on the H3K9 monomethylation and dimethylation of HT‐1080 cells. Parental and KDM3B over HT‐1080 cells were collected and lysed for Western blot detection. H3 was used as endogenous control. (D) The effect of JMJD1C stable overexpression on the H3K9 monomethylation and dimethylation of 293 cells. Parental and JMJD1C over HT‐1080 cells were collected and lysed for Western blot detection. H3 was used as endogenous control. (E) The effect of KDM3B inhibitor JDI‐16 on Erastin‐induced repression of cell proliferation of THP‐1 cells. THP‐1 cells were plated in 96‐well round‐bottom plates at a concentration of 4000 cells per well and incubated with indicated compounds (Erastin, 5 μ m , JDI‐16, 12.5 μ m ) 24 h after plating. Four days later, cells were collected for proliferation detection. For (A, B, E), three independent experiments were performed, quantitative results are reported as mean ± SD, the statistical analysis was performed using Student's t ‐test, and P value smaller than 0.05 (represented by *) was regarded as statistically significant.
Gene Exp Kdm3b Hs00213240 M1, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 86 stars, based on 1 article reviews
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86/100 stars
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Image Search Results


Figure 1. Kdm3b plays an important role in reprogramming to pluripotency.

Journal: The EMBO journal

Article Title: Coordinated removal of repressive epigenetic modifications during induced reversal of cell identity.

doi: 10.15252/embj.2019101681

Figure Lengend Snippet: Figure 1. Kdm3b plays an important role in reprogramming to pluripotency.

Article Snippet: Antibodies used were H3K9me1 1:5,000 (Abcam Ab9045), H3K9me2 1:1,000 (Abcam Ab1220), Kdm3b 1:1,000 (Cell Signaling 5377), Kdm3a 1:1,000 (Proteintech, 12835-1-AP), 1:1,000 Jmjd1c (MBL, D356-3), 1:1,000 POU5F1 (Santa Cruz, sc-5279 or sc-8628), 1:1,000 alpha-Tubulin (Cell Signaling, 3873), and 1:1,000 NSD3 (Thermo Fisher, PA5-28972).

Techniques:

Figure 5. Kdm3b-KO cells retain 5hmC at pluripotency-associated locations where it should be resolved in reprogramming.

Journal: The EMBO journal

Article Title: Coordinated removal of repressive epigenetic modifications during induced reversal of cell identity.

doi: 10.15252/embj.2019101681

Figure Lengend Snippet: Figure 5. Kdm3b-KO cells retain 5hmC at pluripotency-associated locations where it should be resolved in reprogramming.

Article Snippet: Antibodies used were H3K9me1 1:5,000 (Abcam Ab9045), H3K9me2 1:1,000 (Abcam Ab1220), Kdm3b 1:1,000 (Cell Signaling 5377), Kdm3a 1:1,000 (Proteintech, 12835-1-AP), 1:1,000 Jmjd1c (MBL, D356-3), 1:1,000 POU5F1 (Santa Cruz, sc-5279 or sc-8628), 1:1,000 alpha-Tubulin (Cell Signaling, 3873), and 1:1,000 NSD3 (Thermo Fisher, PA5-28972).

Techniques:

The effect of KDM3B overexpression on the Erastin‐induced ferroptosis. (A) The effect of KDM3B in HT‐1080 cells on the ferroptosis induced by Erastin (5 μ m ) and RSL3 (2.5 μ m ). KDM3B stably overexpressed HT‐1080 was constructed as described in the materials and methods. Parental and KDM3B over cells were plated in 96‐well plates at a concentration of 1500 cells per well and incubated with indicated compounds 24 h after plating. Three days later, cells were collected for proliferation detection. (B) The effect of JMJD1C in 293 cells on the ferroptosis induced by Erastin (5 μ m ) and RSL3 (2.5 μ m ). JMJD1C stably overexpressed 293 was constructed as described in the materials and methods. Parental and JMJD1C over cells were plated in 96‐well plates at a concentration of 1500 cells per well and incubated with indicated compounds 24 h after plating. Three days later, cells were collected for proliferation detection. (C) The effect of KDM3B stable overexpression on the H3K9 monomethylation and dimethylation of HT‐1080 cells. Parental and KDM3B over HT‐1080 cells were collected and lysed for Western blot detection. H3 was used as endogenous control. (D) The effect of JMJD1C stable overexpression on the H3K9 monomethylation and dimethylation of 293 cells. Parental and JMJD1C over HT‐1080 cells were collected and lysed for Western blot detection. H3 was used as endogenous control. (E) The effect of KDM3B inhibitor JDI‐16 on Erastin‐induced repression of cell proliferation of THP‐1 cells. THP‐1 cells were plated in 96‐well round‐bottom plates at a concentration of 4000 cells per well and incubated with indicated compounds (Erastin, 5 μ m , JDI‐16, 12.5 μ m ) 24 h after plating. Four days later, cells were collected for proliferation detection. For (A, B, E), three independent experiments were performed, quantitative results are reported as mean ± SD, the statistical analysis was performed using Student's t ‐test, and P value smaller than 0.05 (represented by *) was regarded as statistically significant.

Journal: FEBS Open Bio

Article Title: Histone demethylase KDM3B protects against ferroptosis by upregulating SLC7A11

doi: 10.1002/2211-5463.12823

Figure Lengend Snippet: The effect of KDM3B overexpression on the Erastin‐induced ferroptosis. (A) The effect of KDM3B in HT‐1080 cells on the ferroptosis induced by Erastin (5 μ m ) and RSL3 (2.5 μ m ). KDM3B stably overexpressed HT‐1080 was constructed as described in the materials and methods. Parental and KDM3B over cells were plated in 96‐well plates at a concentration of 1500 cells per well and incubated with indicated compounds 24 h after plating. Three days later, cells were collected for proliferation detection. (B) The effect of JMJD1C in 293 cells on the ferroptosis induced by Erastin (5 μ m ) and RSL3 (2.5 μ m ). JMJD1C stably overexpressed 293 was constructed as described in the materials and methods. Parental and JMJD1C over cells were plated in 96‐well plates at a concentration of 1500 cells per well and incubated with indicated compounds 24 h after plating. Three days later, cells were collected for proliferation detection. (C) The effect of KDM3B stable overexpression on the H3K9 monomethylation and dimethylation of HT‐1080 cells. Parental and KDM3B over HT‐1080 cells were collected and lysed for Western blot detection. H3 was used as endogenous control. (D) The effect of JMJD1C stable overexpression on the H3K9 monomethylation and dimethylation of 293 cells. Parental and JMJD1C over HT‐1080 cells were collected and lysed for Western blot detection. H3 was used as endogenous control. (E) The effect of KDM3B inhibitor JDI‐16 on Erastin‐induced repression of cell proliferation of THP‐1 cells. THP‐1 cells were plated in 96‐well round‐bottom plates at a concentration of 4000 cells per well and incubated with indicated compounds (Erastin, 5 μ m , JDI‐16, 12.5 μ m ) 24 h after plating. Four days later, cells were collected for proliferation detection. For (A, B, E), three independent experiments were performed, quantitative results are reported as mean ± SD, the statistical analysis was performed using Student's t ‐test, and P value smaller than 0.05 (represented by *) was regarded as statistically significant.

Article Snippet: KDM3B siRNA was purchased from Qiagen (Shanghai, China).

Techniques: Over Expression, Stable Transfection, Construct, Concentration Assay, Incubation, Western Blot

The transcriptional regulation of SLC7A11 by KDM3B. (A–F) The mRNA levels of indicated genes affected by KDM3B overexpression. Parental and KDM3B overexpressed HT‐1080 cells were collected for RNA extraction and qPCR. GAPDH was used as an endogenous control. (G) The effect of enforced ATF4, p53, KDM3B, and the combination on the SLC7A11 promoter activities. The SLC7A11 promoter reporter along with ATF4, p53, and KDM3B plasmids was transfected into HT‐1080 cells with pRL‐TK as an endogenous control. (H) The effect of enforced ATF4 and KDM3B siRNA on the SLC7A11 promoter activities. The SLC7A11 promoter reporter along with ATF4 and KDM3B siRNA was transfected into HT‐1080 cells with pRL‐TK as an endogenous control. For (A–H), three independent experiments were performed, quantitative results are reported as mean ± SD, the statistical analysis was performed using Student's t ‐test, and P value smaller than 0.05 (represented by *) was regarded as statistically significant.

Journal: FEBS Open Bio

Article Title: Histone demethylase KDM3B protects against ferroptosis by upregulating SLC7A11

doi: 10.1002/2211-5463.12823

Figure Lengend Snippet: The transcriptional regulation of SLC7A11 by KDM3B. (A–F) The mRNA levels of indicated genes affected by KDM3B overexpression. Parental and KDM3B overexpressed HT‐1080 cells were collected for RNA extraction and qPCR. GAPDH was used as an endogenous control. (G) The effect of enforced ATF4, p53, KDM3B, and the combination on the SLC7A11 promoter activities. The SLC7A11 promoter reporter along with ATF4, p53, and KDM3B plasmids was transfected into HT‐1080 cells with pRL‐TK as an endogenous control. (H) The effect of enforced ATF4 and KDM3B siRNA on the SLC7A11 promoter activities. The SLC7A11 promoter reporter along with ATF4 and KDM3B siRNA was transfected into HT‐1080 cells with pRL‐TK as an endogenous control. For (A–H), three independent experiments were performed, quantitative results are reported as mean ± SD, the statistical analysis was performed using Student's t ‐test, and P value smaller than 0.05 (represented by *) was regarded as statistically significant.

Article Snippet: KDM3B siRNA was purchased from Qiagen (Shanghai, China).

Techniques: Over Expression, RNA Extraction, Transfection

Schematic representation of the proposed model that characterizes KDM3B's role in Erastin‐induced ferroptosis. Class I FIN (ferroptosis inducer) Erastin and class II FIN RSL3 induce ferroptosis dependent on SLC7A11 and GPX4, respectively. KDM3B transcriptionally upregulates SLC7A11, probably through ATF4 and p53, to confer ferroptosis resistance. KDM3B also represses VDAC3 and CARS. KDM3B inhibitor JDI‐16 could resensitize cells to Erastin‐induced proliferation repression.

Journal: FEBS Open Bio

Article Title: Histone demethylase KDM3B protects against ferroptosis by upregulating SLC7A11

doi: 10.1002/2211-5463.12823

Figure Lengend Snippet: Schematic representation of the proposed model that characterizes KDM3B's role in Erastin‐induced ferroptosis. Class I FIN (ferroptosis inducer) Erastin and class II FIN RSL3 induce ferroptosis dependent on SLC7A11 and GPX4, respectively. KDM3B transcriptionally upregulates SLC7A11, probably through ATF4 and p53, to confer ferroptosis resistance. KDM3B also represses VDAC3 and CARS. KDM3B inhibitor JDI‐16 could resensitize cells to Erastin‐induced proliferation repression.

Article Snippet: KDM3B siRNA was purchased from Qiagen (Shanghai, China).

Techniques: