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cxcl12 elisa kit  (Krishgen Biosystems)
90
Krishgen Biosystems cxcl12 elisa kit
( A ) <t>CXCL12</t> plasma levels of MF patients (total n =24; JAK2 V617F mutated patients n = 16; CALR mutated patients n = 8) and controls ( n = 10). Regardless mutation status, CXCL12 concentration was significantly higher in MF patients ( *p ≤ 0.05 vs controls ). ( B ) When cells were migrated toward CXCL12 alone, an increased migration ability was observed in MF-derived ( n = 15) CD34 + cells as compared with the CB-derived ( n = 8) counterparts. The addition of inflammatory factors alone (IL-1β/TNF-α) plus CXCL12 significantly increased the migratory behaviour of MF-derived CD34 + cells as compared with CXCL12 alone. IL-1β + TNF-α synergistically enhanced the migratory behaviour of CD34 + cells as compared with spontaneous migration ( ****p < 0.0001 ), CXCL12 alone ( **p <0.001 ) and the CB-counterpart ( #### p <0.0001). Results are expressed as mean percentages ± SEM of input. (**p ≤ 0.01; ***p ≤ 0.001 vs CXCL12 alone for CB-derived CD34 + cells ) ( *p ≤ 0.05; **p ≤ 0.01; ****p < 0.0001 vs spontaneous migration for MF-derived CD34 + cells ) ( # p ≤ 0.05; #### p <0.0001 vs CB ).
Cxcl12 Elisa Kit, supplied by Krishgen Biosystems, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 90 stars, based on 1 article reviews
cxcl12 elisa kit - by Bioz Stars, 2026-02
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( A ) CXCL12 plasma levels of MF patients (total n =24; JAK2 V617F mutated patients n = 16; CALR mutated patients n = 8) and controls ( n = 10). Regardless mutation status, CXCL12 concentration was significantly higher in MF patients ( *p ≤ 0.05 vs controls ). ( B ) When cells were migrated toward CXCL12 alone, an increased migration ability was observed in MF-derived ( n = 15) CD34 + cells as compared with the CB-derived ( n = 8) counterparts. The addition of inflammatory factors alone (IL-1β/TNF-α) plus CXCL12 significantly increased the migratory behaviour of MF-derived CD34 + cells as compared with CXCL12 alone. IL-1β + TNF-α synergistically enhanced the migratory behaviour of CD34 + cells as compared with spontaneous migration ( ****p < 0.0001 ), CXCL12 alone ( **p <0.001 ) and the CB-counterpart ( #### p <0.0001). Results are expressed as mean percentages ± SEM of input. (**p ≤ 0.01; ***p ≤ 0.001 vs CXCL12 alone for CB-derived CD34 + cells ) ( *p ≤ 0.05; **p ≤ 0.01; ****p < 0.0001 vs spontaneous migration for MF-derived CD34 + cells ) ( # p ≤ 0.05; #### p <0.0001 vs CB ).

Journal: Oncotarget

Article Title: Crucial factors of the inflammatory microenvironment (IL-1β/TNF-α/TIMP-1) promote the maintenance of the malignant hemopoietic clone of myelofibrosis: an in vitro study

doi: 10.18632/oncotarget.9949

Figure Lengend Snippet: ( A ) CXCL12 plasma levels of MF patients (total n =24; JAK2 V617F mutated patients n = 16; CALR mutated patients n = 8) and controls ( n = 10). Regardless mutation status, CXCL12 concentration was significantly higher in MF patients ( *p ≤ 0.05 vs controls ). ( B ) When cells were migrated toward CXCL12 alone, an increased migration ability was observed in MF-derived ( n = 15) CD34 + cells as compared with the CB-derived ( n = 8) counterparts. The addition of inflammatory factors alone (IL-1β/TNF-α) plus CXCL12 significantly increased the migratory behaviour of MF-derived CD34 + cells as compared with CXCL12 alone. IL-1β + TNF-α synergistically enhanced the migratory behaviour of CD34 + cells as compared with spontaneous migration ( ****p < 0.0001 ), CXCL12 alone ( **p <0.001 ) and the CB-counterpart ( #### p <0.0001). Results are expressed as mean percentages ± SEM of input. (**p ≤ 0.01; ***p ≤ 0.001 vs CXCL12 alone for CB-derived CD34 + cells ) ( *p ≤ 0.05; **p ≤ 0.01; ****p < 0.0001 vs spontaneous migration for MF-derived CD34 + cells ) ( # p ≤ 0.05; #### p <0.0001 vs CB ).

Article Snippet: In particular, the TIMP-1 ELISA kit was provided from Boster Immunoleader (Boster Biological Technology Co., Pleasanton, CA, USA) and CXCL12 ELISA kit from Krishgen ByoSistems (Ashley CT, Whittier, CA, USA).

Techniques: Mutagenesis, Concentration Assay, Migration, Derivative Assay

Panels ( A and B ) show the clonogenic potential of CB-derived (A; n = 6) and MF-derived CD34 + cells (B; n = 14) at baseline with or without various combinations of pro-inflammatory factors (CFU-C) and after migration toward CXCL12 alone or various combinations of pro-inflammatory factors + CXCL12 (CFU-C post-migration). After migration toward IL-1β + TNF-α + CXCL12 ± TIMP-1, the MF-derived, but not CB-derived, CD34 + cells show significantly increased clonogenic potential. Results are expressed as mean fold change of CFU-C ± SEM. ( *p ≤ 0.05 vs untreated cells (A) and CXCL12 alone (B) ).

Journal: Oncotarget

Article Title: Crucial factors of the inflammatory microenvironment (IL-1β/TNF-α/TIMP-1) promote the maintenance of the malignant hemopoietic clone of myelofibrosis: an in vitro study

doi: 10.18632/oncotarget.9949

Figure Lengend Snippet: Panels ( A and B ) show the clonogenic potential of CB-derived (A; n = 6) and MF-derived CD34 + cells (B; n = 14) at baseline with or without various combinations of pro-inflammatory factors (CFU-C) and after migration toward CXCL12 alone or various combinations of pro-inflammatory factors + CXCL12 (CFU-C post-migration). After migration toward IL-1β + TNF-α + CXCL12 ± TIMP-1, the MF-derived, but not CB-derived, CD34 + cells show significantly increased clonogenic potential. Results are expressed as mean fold change of CFU-C ± SEM. ( *p ≤ 0.05 vs untreated cells (A) and CXCL12 alone (B) ).

Article Snippet: In particular, the TIMP-1 ELISA kit was provided from Boster Immunoleader (Boster Biological Technology Co., Pleasanton, CA, USA) and CXCL12 ELISA kit from Krishgen ByoSistems (Ashley CT, Whittier, CA, USA).

Techniques: Derivative Assay, Migration