Journal: Bioengineering & Translational Medicine

Article Title: Kartogenin (KGN)/synthetic melanin nanoparticles (SMNP) loaded theranostic hydrogel scaffold system for multiparametric magnetic resonance imaging guided cartilage regeneration

doi: 10.1002/btm2.10364

Figure Lengend Snippet: Schematic illustration of preparation and functionalization of kartogenin loaded and SMNP labeled multifunctional hydrogel scaffold for cartilage regeneration

Article Snippet: Kartogenin (KGN) and acetone were obtained from Macklin Co., Ltd. (Shanghai, China).

Techniques: Labeling

Journal: International Journal of Molecular Sciences

Article Title: Benefits of Applying Nanotechnologies to Hydrogels in Efficacy Tests in Osteoarthritis Models—A Systematic Review of Preclinical Studies

doi: 10.3390/ijms23158236

Figure Lengend Snippet: Summary of the in vivo preclinical studies.

Article Snippet: Chitosan-kartogenin NPs (size 150 ± 39 nm, spherical) , Drug delivery (kartogenin) , Bilateral ACLT in rats (8 male Sprague Dawley rats for each group) , Two i.a. applications after 42 and 63 days after ACLT , In vivo retention time; histology (OARSI score) , In vivo retention time: NPs showed long retention in the OA joint; histology: lower OARSI score in treated joints , In vivo retention time: 2, 4, 7, 14, and 24 days after treatment; histology: 35 days post-treatment , Kang 2014 [ ] .

Techniques: In Vivo, Animal Model, Binding Assay, Micro-CT, Membrane, Activity Assay, Histopathology, Injection, Immunostaining, Reverse Transcription Polymerase Chain Reaction, Fluorescence