jwg071 Search Results


jwg071  (MedChemExpress)
93
MedChemExpress jwg071
Jwg071, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/jwg071/product/MedChemExpress
Average 93 stars, based on 1 article reviews
jwg071 - by Bioz Stars, 2026-02
93/100 stars
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jwg-071  (DiscoverX corporation)
90
DiscoverX corporation jwg-071
(A) Overlay of structures of XMD11–50 (green), JWG-048 (salmon), JWG-046 (orange), <t>JWG-071(pink),</t> JWG-069 (cyan) and XMD17–26 (yellow) highlighting the different curvature of the diazipinone ring system and deviation of the tail. (B) Overlay of Roco4/XMD11–50 (pdb code 4YZM, top), and ERK5/XMD17–26 (pdb code 4B99, bottom), crystal structure reveal differences in P-loop (red) conformation and explain observed R2 SAR. (C) Overlay of JWG-047 and XMD17–26 in complex with BRD4-BD1 reveal differences in local interactions and the presence of a new water molecule in the JWG-047. Composite-omit map of JWG-047 in 2Fo-Fc format with a σ-level at 2.0.
Jwg 071, supplied by DiscoverX corporation, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/jwg-071/product/DiscoverX corporation
Average 90 stars, based on 1 article reviews
jwg-071 - by Bioz Stars, 2026-02
90/100 stars
  Buy from Supplier
jwg-071  (Merck & Co)
90
Merck & Co jwg-071
(A) Overlay of structures of XMD11–50 (green), JWG-048 (salmon), JWG-046 (orange), <t>JWG-071(pink),</t> JWG-069 (cyan) and XMD17–26 (yellow) highlighting the different curvature of the diazipinone ring system and deviation of the tail. (B) Overlay of Roco4/XMD11–50 (pdb code 4YZM, top), and ERK5/XMD17–26 (pdb code 4B99, bottom), crystal structure reveal differences in P-loop (red) conformation and explain observed R2 SAR. (C) Overlay of JWG-047 and XMD17–26 in complex with BRD4-BD1 reveal differences in local interactions and the presence of a new water molecule in the JWG-047. Composite-omit map of JWG-047 in 2Fo-Fc format with a σ-level at 2.0.
Jwg 071, supplied by Merck & Co, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/jwg-071/product/Merck & Co
Average 90 stars, based on 1 article reviews
jwg-071 - by Bioz Stars, 2026-02
90/100 stars
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erk5 inhibitor jwg071  (Glixx Laboratories Inc)
90
Glixx Laboratories Inc erk5 inhibitor jwg071
Soluble NRG binds and activates ErbB/HER receptors and triggers the activation of several intracellular signaling pathways (ERK1/2, <t>ERK5,</t> and PI3K-AKT-mTOR). These pathways regulate simultaneously ERα phosphorylation at serines 118 and 167 and their expression levels through the proteasome or at the transcriptional level. Furthermore, simultaneously activation of these signaling pathways by NRG receptors induce resistance to fulvestrant. Inhibitors used to block the different signaling pathways are shown in red.
Erk5 Inhibitor Jwg071, supplied by Glixx Laboratories Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/erk5 inhibitor jwg071/product/Glixx Laboratories Inc
Average 90 stars, based on 1 article reviews
erk5 inhibitor jwg071 - by Bioz Stars, 2026-02
90/100 stars
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Image Search Results


(A) Overlay of structures of XMD11–50 (green), JWG-048 (salmon), JWG-046 (orange), JWG-071(pink), JWG-069 (cyan) and XMD17–26 (yellow) highlighting the different curvature of the diazipinone ring system and deviation of the tail. (B) Overlay of Roco4/XMD11–50 (pdb code 4YZM, top), and ERK5/XMD17–26 (pdb code 4B99, bottom), crystal structure reveal differences in P-loop (red) conformation and explain observed R2 SAR. (C) Overlay of JWG-047 and XMD17–26 in complex with BRD4-BD1 reveal differences in local interactions and the presence of a new water molecule in the JWG-047. Composite-omit map of JWG-047 in 2Fo-Fc format with a σ-level at 2.0.

Journal: ACS chemical biology

Article Title: Structural and atropisomeric factors governing the selectivity of pyrimido-benzodiazipinones as inhibitors of kinases and bromodomains

doi: 10.1021/acschembio.7b00638

Figure Lengend Snippet: (A) Overlay of structures of XMD11–50 (green), JWG-048 (salmon), JWG-046 (orange), JWG-071(pink), JWG-069 (cyan) and XMD17–26 (yellow) highlighting the different curvature of the diazipinone ring system and deviation of the tail. (B) Overlay of Roco4/XMD11–50 (pdb code 4YZM, top), and ERK5/XMD17–26 (pdb code 4B99, bottom), crystal structure reveal differences in P-loop (red) conformation and explain observed R2 SAR. (C) Overlay of JWG-047 and XMD17–26 in complex with BRD4-BD1 reveal differences in local interactions and the presence of a new water molecule in the JWG-047. Composite-omit map of JWG-047 in 2Fo-Fc format with a σ-level at 2.0.

Article Snippet: Having identified a kinase class-selective compound, the kinome wide selectivity of JWG-071 was assessed using the KinomeScan methodology (DiscoverX) across a panel of 468 human kinases at a concentration of 1 μM.

Techniques:

Soluble NRG binds and activates ErbB/HER receptors and triggers the activation of several intracellular signaling pathways (ERK1/2, ERK5, and PI3K-AKT-mTOR). These pathways regulate simultaneously ERα phosphorylation at serines 118 and 167 and their expression levels through the proteasome or at the transcriptional level. Furthermore, simultaneously activation of these signaling pathways by NRG receptors induce resistance to fulvestrant. Inhibitors used to block the different signaling pathways are shown in red.

Journal: Clinical Science (London, England : 1979)

Article Title: Neuregulin modulates hormone receptor levels in breast cancer through concerted action on multiple signaling pathways

doi: 10.1042/CS20220472

Figure Lengend Snippet: Soluble NRG binds and activates ErbB/HER receptors and triggers the activation of several intracellular signaling pathways (ERK1/2, ERK5, and PI3K-AKT-mTOR). These pathways regulate simultaneously ERα phosphorylation at serines 118 and 167 and their expression levels through the proteasome or at the transcriptional level. Furthermore, simultaneously activation of these signaling pathways by NRG receptors induce resistance to fulvestrant. Inhibitors used to block the different signaling pathways are shown in red.

Article Snippet: The ERK5 inhibitor JWG071 was from Glixx Laboratories Inc (Hopkinton, MA, U.S.A.).

Techniques: Activation Assay, Protein-Protein interactions, Phospho-proteomics, Expressing, Blocking Assay