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Image Search Results
Journal: Clinical and Translational Gastroenterology
Article Title: β 6 -Integrin Serves as a Potential Serum Marker for Diagnosis and Prognosis of Pancreatic Adenocarcinoma
doi: 10.14309/ctg.0000000000000395
Figure Lengend Snippet: Validation of ITGB6 as possible biomarker for PAC. ( a ) Serum ITGB6 levels were assessed in a prospective study cohort of 27 patients with PAC (cohort 1, N = 27). As control served 9 healthy volunteers (Ctrl; N = 9) and 10 patients with cP (N = 10). Significant differences in ITGB6 levels were observed between patients with PAC and Ctrl ( P = 0.019). ( b ) Comparing patients with or without distant metastatic PAC, serum ITGB6 levels were not significantly different. However, a significant increase in ITGB6 levels was observed between Ctrl and patients with nonmetastatic PAC ( P = 0.019). ( c ) To assess the prognostic value of serum ITGB6 levels, patients with PAC were plotted against their status of survival at time of blood assessment. A significant difference in ITGB6 concentration was observed between patients with PAC with status alive vs dead ( P = 0.007). ( d ) Two-dimensional scatterplots depict serum ITGB6 levels in relation to the serum CA19-9 levels from each cP ( r s = 0.511; P = 0.132) and patient with PAC ( r s = 0.210; P = 0.302). In ( a – c ), Mann–Whitney U Exact and Sig. 2-Tailed test were performed, and in ( d ), Spearman's rho correlation ( r s ) and Sig. 2-tailed test were performed. ( d ) Red lines indicate ITGB6 cutoff value at 0.1 ng/mL and black line CA19-9 cutoff value at 37.0 kU/L, respectively. cP, chronic pancreatitis; Ctrl, control; ITGB6, β 6 -integrin; PAC, pancreatic adenocarcinoma; r s, Spearman's rho correlation. *Means P < 0.05.
Article Snippet: A tissue microarray (TMA) with formalin-fixed paraffin-embedded PAC tissue specimens from 83 patients was automatically stained with a human
Techniques: Biomarker Discovery, Control, Concentration Assay, MANN-WHITNEY
Journal: Clinical and Translational Gastroenterology
Article Title: β 6 -Integrin Serves as a Potential Serum Marker for Diagnosis and Prognosis of Pancreatic Adenocarcinoma
doi: 10.14309/ctg.0000000000000395
Figure Lengend Snippet: Serum ITGB6 levels may predict overall and progression-free survival in patients with PAC. ( a ) Survival rates and ( b ) progression-free survival of patients with PAC who underwent systemic therapy are plotted according to serum ITGB6 changes after initiation (N = 24; cohort 2). ( c ) Two-dimensional scatterplots depict lymph node ratio (LNR) in relation to exits after surgery (months) for each patient in accordance to the ITGB6 protein expression pattern. Hazard ratio (HR) was calculated with the Cox regression. ( d ) Overall survival in AU12 patients with PAC (N582; cohort 3) was plotted according to ITGB6 protein expression pattern. Kaplan-Meier estimation was performed and plotted accordingly. The log-rank P values are indicated. ITGB6, β 6 -integrin; PAC, pancreatic adenocarcinoma.
Article Snippet: A tissue microarray (TMA) with formalin-fixed paraffin-embedded PAC tissue specimens from 83 patients was automatically stained with a human
Techniques: Expressing
Journal: Clinical and Translational Gastroenterology
Article Title: β 6 -Integrin Serves as a Potential Serum Marker for Diagnosis and Prognosis of Pancreatic Adenocarcinoma
doi: 10.14309/ctg.0000000000000395
Figure Lengend Snippet: ITGB6 protein expression in PAC tissue specimens by IHC. Representative TMA specimens (from cohort 3, N = 83) illustrate ITGB6-negative (no [0] or mild [1+] expression) and ITGB6-positive PAC specimens (moderate [2+] or strong [3+] expression; scale bars: upper panel 200 μm; lower panel 100 μm). IHC, immunohistochemistry; ITGB6, β 6 -integrin; PAC, pancreatic adenocarcinoma; TMA, tissue microarray.
Article Snippet: A tissue microarray (TMA) with formalin-fixed paraffin-embedded PAC tissue specimens from 83 patients was automatically stained with a human
Techniques: Expressing, Immunohistochemistry, Microarray