Journal: PLoS ONE

Article Title: Characterization of Synaptically Connected Nuclei in a Potential Sensorimotor Feedback Pathway in the Zebra Finch Song System

doi: 10.1371/journal.pone.0032178

Figure Lengend Snippet: Response strength (units/s) and z-scores for simultaneous recordings in HVC and MMAN to auditory playback (N = 17 from 16 birds).

Article Snippet: Although almost all of the auditory activity in HVC originates from NIf and CM there could be other auditory inputs to HVC as preliminary data suggest that bilateral lesions of these two areas do not result in song degradation, as seen with deafening .

Techniques:

Journal: PLoS ONE

Article Title: Characterization of Synaptically Connected Nuclei in a Potential Sensorimotor Feedback Pathway in the Zebra Finch Song System

doi: 10.1371/journal.pone.0032178

Figure Lengend Snippet: A. Comparison of the response strength in HVC and MMAN. HVC had a significantly larger RS to BOS than did MMAN (*; paired t-test, p<0.05). The response to REV and CON in HVC and MMAN were not significantly different (REV, p = 0.17; CON, p = 0.47). B. Z-score for auditory-evoked activity in HVC and MMAN. HVC had a significantly higher z-score to BOS than did MMAN (*; paired t-test, BOS, p<0.01). The response in HVC and MMAN to REV and CON were not significantly different (REV, p = 0.20; CON, p = 0.15). C. Comparison of z-scores from simultaneous recorded activity in HVC and mMAN. Black diagonal line is the unity line. D. Both HVC and MMAN were selective for BOS vs REV and BOS vs CON. Selectivity was defined as d′>0.5 (dashed horizontal line). E. HVC was more selective for BOS versus CON than simultaneously recorded MMAN, as many points lie above the unity line than expected at random (p<0.05). The points for BOS versus CON did not lie significantly above the unity line than expected at random (p>0.05). The grey bars demark non-significant d′ values for MMAN and HVC; i.e., −0.5>d′>0.5.

Article Snippet: Although almost all of the auditory activity in HVC originates from NIf and CM there could be other auditory inputs to HVC as preliminary data suggest that bilateral lesions of these two areas do not result in song degradation, as seen with deafening .

Techniques: Comparison, Activity Assay

Journal: PLoS ONE

Article Title: Characterization of Synaptically Connected Nuclei in a Potential Sensorimotor Feedback Pathway in the Zebra Finch Song System

doi: 10.1371/journal.pone.0032178

Figure Lengend Snippet: A. Example of auditory evoked activity in MMAN and HVC before (left) and with (right) GABA application to MMAN. Top trace, PSTH of HVC response to ten iterations of BOS playback. Bin size, 25 ms. Middle trace, single, raw example of multiunit activity in HVC. Bottom trace, sonogram of BOS. B. Location of GABA application in MMAN approximated by rhodamine labeling (arrows). LMAN is outlined to the right of the dye (dotted semicircle, *). Scale bar, 200 µm. The dashed vertical line denotes the midline. Dorsal is upward. C. Average response of HVC to BOS presentation before (pre), during (GABA) and after (post) BOS presentation. In two experiments (filled squares) GABA application to MMAN did not produce a significant change in HVC response. In one experiment (open squares) there was a significant decrease in the HVC response to BOS during GABA application compared to pre and post GABA application (ANOVA, p<0.5, Tukey post-hoc). In one bird (open stars) the response to BOS increased throughout the duration of the experiment (pre, GABA, and post were all significantly different than each other; p<0.5, ANOVA, Tukey post-hoc). D. Normalized responses of data shown in C.

Article Snippet: Although almost all of the auditory activity in HVC originates from NIf and CM there could be other auditory inputs to HVC as preliminary data suggest that bilateral lesions of these two areas do not result in song degradation, as seen with deafening .

Techniques: Activity Assay, Labeling