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Selected immune checkpoint inhibitors in clinical trials.
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The IDO inhibitors epacadostat ( 21 ), EOS‐200271 ( 22 ), navoximod ( 23 a ) and <t>indoximod</t> ( 23 b ), and BMS‐986205 ( 24 ).
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NewLink Genetics indoleamine 2, 3-dioxygenase (ido) inhibitor – indoximod
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Image Search Results


Journal: eLife

Article Title: A powerful drug combination strategy targeting glutamine addiction for the treatment of human liver cancer

doi: 10.7554/eLife.56749

Figure Lengend Snippet:

Article Snippet: Chemical compound, drug , NLG-8189 , Selleck Chemical , S7756 , .

Techniques: Flow Cytometry, Software

Selected immune checkpoint inhibitors in clinical trials.

Journal: Therapeutic Advances in Respiratory Disease

Article Title: New strategies in immunotherapy for lung cancer: beyond PD-1/PD-L1

doi: 10.1177/1753466618794133

Figure Lengend Snippet: Selected immune checkpoint inhibitors in clinical trials.

Article Snippet: , Indoximod (NLG0401) (IDOi) , NewLink Genetics Corp , Indoximod combination with docetaxel, tergenpumatucel-L , NSCLC, at least one prior platinum-doublet chemotherapy , NCT02460367 , Phase I/II Unknown.

Techniques: Recombinant

The IDO inhibitors epacadostat ( 21 ), EOS‐200271 ( 22 ), navoximod ( 23 a ) and indoximod ( 23 b ), and BMS‐986205 ( 24 ).

Journal: Angewandte Chemie (International Ed. in English)

Article Title: Small Molecules Drive Big Improvements in Immuno‐Oncology Therapies

doi: 10.1002/anie.201707816

Figure Lengend Snippet: The IDO inhibitors epacadostat ( 21 ), EOS‐200271 ( 22 ), navoximod ( 23 a ) and indoximod ( 23 b ), and BMS‐986205 ( 24 ).

Article Snippet: NewLink Genetics is also investigating indoximod ( 23 b ), which is a direct inhibitor of neither IDO nor TDO at relevant pharmaceutical concentrations.

Techniques:

Open studies from CT.Gov 20150528

Journal: Neuro-Oncology

Article Title: Vaccination strategies for neuro-oncology

doi: 10.1093/neuonc/nov159

Figure Lengend Snippet: Open studies from CT.Gov 20150528

Article Snippet: 02052648 , A Phase I/II Study of the Combination of Indoximod and Temozolomide for Adult Patients With Temozolomide-Refractory Primary Malignant Brain Tumors , NewLink Genetics Corporation , In this study, investigators will conduct a phase I/II trial in recurrent (temozolomide resistant) glioma patients. The overall goal of this study is to provide a foundation for future studies with indoximod tested in newly diagnosed glioblastoma patients with radiation and temozolomide, or in combination with vaccine therapies , Indoleamine 2, 3-dioxygenase (IDO) inhibitor – Indoximod is given in combination with TMZ or bevacizumab, or with TMZ and stereotactic radiation..

Techniques: In Situ, Control, Derivative Assay, Produced, Immunopeptidomics, Expressing, Clinical Proteomics, Transplantation Assay, Vaccines, Injection, Cream, Virus, Biomarker Discovery, Recombinant, Modification