human sirtuin 3 Search Results


sirt3 agonist  (MedChemExpress)
93
MedChemExpress sirt3 agonist
<t>SIRT3</t> suppresses mitophagy-dependent ferroptosis, restoring the osteogenic capacity of MC3T3-E1 cells. (A) Machine learning (LASSO/SVM-RFE/Random Forest) identified GIOP-mitophagy associated genes. (B) SIRT3 expression correlated with GIOP progression. (C) qRT-PCR quantified PINK1/PARKIN mRNA in DEX-treated cells. (D-E) Western blot detected PINK1/PARKIN protein in DEX/DEX + SIRT3 groups. (F) IF visualized SIRT3 alterations (DEX group, 50 μm). (G) Multiplex IF showed GPX4/TFR/PINK1/PARKIN/SIRT3 changes (DEX/DEX + SIRT3, 50 μm). (H-I) Osteogenic capacity assessed by ALP/ARS staining. (J-K) Oxidative stress markers (MDA/GSH) measured. (L) qPCR analyzed PINK1/PARKIN/RUNX2/OPG/SIRT3 expression. Experimental design: n =3 biological replicates (technical triplicates). Data: mean ± SD. Statistics: one-way ANOVA. (*P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001).
Sirt3 Agonist, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/sirt3 agonist/product/MedChemExpress
Average 93 stars, based on 1 article reviews
sirt3 agonist - by Bioz Stars, 2026-05
93/100 stars
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human sirtuin 3  (Shanghai Korain Biotech Co Ltd)
92
Shanghai Korain Biotech Co Ltd human sirtuin 3
<t>SIRT3</t> suppresses mitophagy-dependent ferroptosis, restoring the osteogenic capacity of MC3T3-E1 cells. (A) Machine learning (LASSO/SVM-RFE/Random Forest) identified GIOP-mitophagy associated genes. (B) SIRT3 expression correlated with GIOP progression. (C) qRT-PCR quantified PINK1/PARKIN mRNA in DEX-treated cells. (D-E) Western blot detected PINK1/PARKIN protein in DEX/DEX + SIRT3 groups. (F) IF visualized SIRT3 alterations (DEX group, 50 μm). (G) Multiplex IF showed GPX4/TFR/PINK1/PARKIN/SIRT3 changes (DEX/DEX + SIRT3, 50 μm). (H-I) Osteogenic capacity assessed by ALP/ARS staining. (J-K) Oxidative stress markers (MDA/GSH) measured. (L) qPCR analyzed PINK1/PARKIN/RUNX2/OPG/SIRT3 expression. Experimental design: n =3 biological replicates (technical triplicates). Data: mean ± SD. Statistics: one-way ANOVA. (*P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001).
Human Sirtuin 3, supplied by Shanghai Korain Biotech Co Ltd, used in various techniques. Bioz Stars score: 92/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/human sirtuin 3/product/Shanghai Korain Biotech Co Ltd
Average 92 stars, based on 1 article reviews
human sirtuin 3 - by Bioz Stars, 2026-05
92/100 stars
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recombinant human his sirtuin 3  (R&D Systems)
94
R&D Systems recombinant human his sirtuin 3
<t>SIRT3</t> suppresses mitophagy-dependent ferroptosis, restoring the osteogenic capacity of MC3T3-E1 cells. (A) Machine learning (LASSO/SVM-RFE/Random Forest) identified GIOP-mitophagy associated genes. (B) SIRT3 expression correlated with GIOP progression. (C) qRT-PCR quantified PINK1/PARKIN mRNA in DEX-treated cells. (D-E) Western blot detected PINK1/PARKIN protein in DEX/DEX + SIRT3 groups. (F) IF visualized SIRT3 alterations (DEX group, 50 μm). (G) Multiplex IF showed GPX4/TFR/PINK1/PARKIN/SIRT3 changes (DEX/DEX + SIRT3, 50 μm). (H-I) Osteogenic capacity assessed by ALP/ARS staining. (J-K) Oxidative stress markers (MDA/GSH) measured. (L) qPCR analyzed PINK1/PARKIN/RUNX2/OPG/SIRT3 expression. Experimental design: n =3 biological replicates (technical triplicates). Data: mean ± SD. Statistics: one-way ANOVA. (*P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001).
Recombinant Human His Sirtuin 3, supplied by R&D Systems, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/recombinant human his sirtuin 3/product/R&D Systems
Average 94 stars, based on 1 article reviews
recombinant human his sirtuin 3 - by Bioz Stars, 2026-05
94/100 stars
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human sirtuin 3 elisa kit  (Cusabio)
93
Cusabio human sirtuin 3 elisa kit
<t>SIRT3</t> suppresses mitophagy-dependent ferroptosis, restoring the osteogenic capacity of MC3T3-E1 cells. (A) Machine learning (LASSO/SVM-RFE/Random Forest) identified GIOP-mitophagy associated genes. (B) SIRT3 expression correlated with GIOP progression. (C) qRT-PCR quantified PINK1/PARKIN mRNA in DEX-treated cells. (D-E) Western blot detected PINK1/PARKIN protein in DEX/DEX + SIRT3 groups. (F) IF visualized SIRT3 alterations (DEX group, 50 μm). (G) Multiplex IF showed GPX4/TFR/PINK1/PARKIN/SIRT3 changes (DEX/DEX + SIRT3, 50 μm). (H-I) Osteogenic capacity assessed by ALP/ARS staining. (J-K) Oxidative stress markers (MDA/GSH) measured. (L) qPCR analyzed PINK1/PARKIN/RUNX2/OPG/SIRT3 expression. Experimental design: n =3 biological replicates (technical triplicates). Data: mean ± SD. Statistics: one-way ANOVA. (*P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001).
Human Sirtuin 3 Elisa Kit, supplied by Cusabio, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/human sirtuin 3 elisa kit/product/Cusabio
Average 93 stars, based on 1 article reviews
human sirtuin 3 elisa kit - by Bioz Stars, 2026-05
93/100 stars
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cf cat 7488 da 050  (R&D Systems)
92
R&D Systems cf cat 7488 da 050
<t>SIRT3</t> suppresses mitophagy-dependent ferroptosis, restoring the osteogenic capacity of MC3T3-E1 cells. (A) Machine learning (LASSO/SVM-RFE/Random Forest) identified GIOP-mitophagy associated genes. (B) SIRT3 expression correlated with GIOP progression. (C) qRT-PCR quantified PINK1/PARKIN mRNA in DEX-treated cells. (D-E) Western blot detected PINK1/PARKIN protein in DEX/DEX + SIRT3 groups. (F) IF visualized SIRT3 alterations (DEX group, 50 μm). (G) Multiplex IF showed GPX4/TFR/PINK1/PARKIN/SIRT3 changes (DEX/DEX + SIRT3, 50 μm). (H-I) Osteogenic capacity assessed by ALP/ARS staining. (J-K) Oxidative stress markers (MDA/GSH) measured. (L) qPCR analyzed PINK1/PARKIN/RUNX2/OPG/SIRT3 expression. Experimental design: n =3 biological replicates (technical triplicates). Data: mean ± SD. Statistics: one-way ANOVA. (*P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001).
Cf Cat 7488 Da 050, supplied by R&D Systems, used in various techniques. Bioz Stars score: 92/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/cf cat 7488 da 050/product/R&D Systems
Average 92 stars, based on 1 article reviews
cf cat 7488 da 050 - by Bioz Stars, 2026-05
92/100 stars
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human sirtuin 3/sirt3 (np_036371.1) versaclone cdna  (R&D Systems)
N/A
Human Sirtuin 3/SIRT3 (NP_036371.1) VersaClone cDNA
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sirt3 human - recombinant human sirtuin-3  (Aviva Systems)
N/A
SIRT3; Recombinant Human SIrtuin-3; Recombinant Human SIrtuin-3
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human sirtuin 3 elisa kit  (Innovative Research Inc)
N/A
Human Sirtuin 3 ELISA Kit from Innovative Research is intended for the quantitative determination of Human Sirtuin 3 in biofluid samples, such as tissue homogenates, cell lysates and other biological fluids. This is a sandwich
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human sirtuin 3 iqelisa kit  (RayBiotech)
N/A
RayBio® Human Immunoquantitative (PCR-Based) Sirtuin 3 ELISA Kit for cell culture supernatants, plasma, and serum samples.
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recombinant human sirtuin 3, his-tagged  (Creative BioMart)
N/A
Recombinant human SIRT3 protein, fused to His-tag at N-terminus, was expressed inE.coliand purified by using conventional chromatography techniques. MW =33.5kDa (303aa) confirmed by MALDI-TOF.NAD-dependent deacetylase sirtuin-3, mitochondrial, also known as SIRT3, belongs to the sirtuin
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recombinant human sirtuin 3 sirt3 protein  (Novus Biologicals)
N/A
The Recombinant Human Sirtuin 3 SIRT3 Protein has been validated for the following applications Western Blot ELISA Protein Array Immunoaffinity Purification
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sheep polyclonal anti-human sirtuin 3  (Angio-Proteomie)
N/A
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Image Search Results


SIRT3 suppresses mitophagy-dependent ferroptosis, restoring the osteogenic capacity of MC3T3-E1 cells. (A) Machine learning (LASSO/SVM-RFE/Random Forest) identified GIOP-mitophagy associated genes. (B) SIRT3 expression correlated with GIOP progression. (C) qRT-PCR quantified PINK1/PARKIN mRNA in DEX-treated cells. (D-E) Western blot detected PINK1/PARKIN protein in DEX/DEX + SIRT3 groups. (F) IF visualized SIRT3 alterations (DEX group, 50 μm). (G) Multiplex IF showed GPX4/TFR/PINK1/PARKIN/SIRT3 changes (DEX/DEX + SIRT3, 50 μm). (H-I) Osteogenic capacity assessed by ALP/ARS staining. (J-K) Oxidative stress markers (MDA/GSH) measured. (L) qPCR analyzed PINK1/PARKIN/RUNX2/OPG/SIRT3 expression. Experimental design: n =3 biological replicates (technical triplicates). Data: mean ± SD. Statistics: one-way ANOVA. (*P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001).

Journal: International Journal of Surgery (London, England)

Article Title: Targeting SIRT3 to regulate mitophagy-dependent ferroptosis for preventing glucocorticoid-induced osteoporosis

doi: 10.1097/JS9.0000000000002783

Figure Lengend Snippet: SIRT3 suppresses mitophagy-dependent ferroptosis, restoring the osteogenic capacity of MC3T3-E1 cells. (A) Machine learning (LASSO/SVM-RFE/Random Forest) identified GIOP-mitophagy associated genes. (B) SIRT3 expression correlated with GIOP progression. (C) qRT-PCR quantified PINK1/PARKIN mRNA in DEX-treated cells. (D-E) Western blot detected PINK1/PARKIN protein in DEX/DEX + SIRT3 groups. (F) IF visualized SIRT3 alterations (DEX group, 50 μm). (G) Multiplex IF showed GPX4/TFR/PINK1/PARKIN/SIRT3 changes (DEX/DEX + SIRT3, 50 μm). (H-I) Osteogenic capacity assessed by ALP/ARS staining. (J-K) Oxidative stress markers (MDA/GSH) measured. (L) qPCR analyzed PINK1/PARKIN/RUNX2/OPG/SIRT3 expression. Experimental design: n =3 biological replicates (technical triplicates). Data: mean ± SD. Statistics: one-way ANOVA. (*P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001).

Article Snippet: A cohort of 40 male Sprague-Dawley rats (8-week-old, SPF-grade) were randomly allocated into four groups (n = 10/group): Control: PBS vehicle Model: GIOP Mdivi-1: GIOP + 15 mg/kg Mdivi-1 (MedChemExpress, HY-15 886) i.p. every 48 h [ ] SIRT3 agonist: GIOP + 200 mg/kg nicotinamide riboside (MedChemExpress, HY-15 452) p.o. daily [ ] .

Techniques: Expressing, Quantitative RT-PCR, Western Blot, Multiplex Assay, Staining

SIRT3 prevents GIOP by regulating mitophagy-dependent ferroptosis (A) Tibial sections were co-stained for FTH/GPX4 and RUNX2/OPG (scale bar = 500 μm). (B) Intracellular ROS levels were visualized by fluorescence staining (scale bar = 1000 μm). (C) Mitophagy markers PINK1/PARKIN were co-localized by IF (scale bar = 100 μm). (D) Micro-CT reconstructed 2D trabecular architecture. (E) Histomorphometric analysis of bone structure (HE staining, scale bar = 200 μm). Experimental design: n =5 biological replicates/group. Data presented as mean ± SD. Statistical analysis: two-tailed Student’s t-test. (*P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001)

Journal: International Journal of Surgery (London, England)

Article Title: Targeting SIRT3 to regulate mitophagy-dependent ferroptosis for preventing glucocorticoid-induced osteoporosis

doi: 10.1097/JS9.0000000000002783

Figure Lengend Snippet: SIRT3 prevents GIOP by regulating mitophagy-dependent ferroptosis (A) Tibial sections were co-stained for FTH/GPX4 and RUNX2/OPG (scale bar = 500 μm). (B) Intracellular ROS levels were visualized by fluorescence staining (scale bar = 1000 μm). (C) Mitophagy markers PINK1/PARKIN were co-localized by IF (scale bar = 100 μm). (D) Micro-CT reconstructed 2D trabecular architecture. (E) Histomorphometric analysis of bone structure (HE staining, scale bar = 200 μm). Experimental design: n =5 biological replicates/group. Data presented as mean ± SD. Statistical analysis: two-tailed Student’s t-test. (*P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001)

Article Snippet: A cohort of 40 male Sprague-Dawley rats (8-week-old, SPF-grade) were randomly allocated into four groups (n = 10/group): Control: PBS vehicle Model: GIOP Mdivi-1: GIOP + 15 mg/kg Mdivi-1 (MedChemExpress, HY-15 886) i.p. every 48 h [ ] SIRT3 agonist: GIOP + 200 mg/kg nicotinamide riboside (MedChemExpress, HY-15 452) p.o. daily [ ] .

Techniques: Staining, Fluorescence, Micro-CT, Two Tailed Test