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Image Search Results
Journal: PLoS ONE
Article Title: Comparative mRNA and miRNA transcriptome analysis of a mouse model of IGFIR-driven lung cancer
doi: 10.1371/journal.pone.0206948
Figure Lengend Snippet: (A) Schematic of doxycycline inducible expression of IGFIR in the mouse lung via the SPC promoter. (B) Unsupervised hierarchical clustering dendrogram of RNA-Seq data from tumor (T, red) and non-transgenic normal lung (N, grey) samples. (C) Volcano plot of log2 fold changes and differential expression p values between tumor and normal lung tissue. (D) Pie chart illustrating percentage of genes up and down-regulated in IGFIR-driven tumors. (E) Dot plots of endogenous murine Igf1r (padj = 5.71E-11) and human IGFIR transgene (padj = 5.65E-249) mRNA expression following mapping to a hybrid genome. (F) Heatmap showing differential expression of markers of AT2 and Club cells as well as subtypes of non-small cell lung cancer. ADC, adenocarcinoma, SCC, squamous cell carcinoma, mADC, mucinous adenocarcinoma. Adjusted p-values for (C) and (E) were obtained from DESeq2.
Article Snippet: To further enrich for tumor cells, a
Techniques: Expressing, RNA Sequencing, Transgenic Assay, Quantitative Proteomics