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Image Search Results
Journal: Antiviral research
Article Title: Feasibility and biological rationale of repurposing sunitinib and erlotinib for dengue treatment
doi: 10.1016/j.antiviral.2018.05.001
Figure Lengend Snippet: AAK1 and GAK transcript levels in bulk (A) and single cell (B-C) DENV infected (MOI=0 (control), 1, 10) Huh7 samples at various time points postinfection, measured via qRT-PCR (A) and virus-inclusive single-cell RNA-Seq (B-C). *P < 0.05, **P < 0.01 in A are relative to vehicle control normalized to TBP (TATA-binding protein) by two-way ANOVA with Tukey’s multiple comparisons test. B. Scatter plots depicting the correlation between vRNA content (viral reads, X axis) and AAK1/GAK gene expression (Y axis) during DENV infection. Each dot represents a single cell, color-coded based on the MOI. ρ represents Spearman correlation coefficients between abundances of dengue vRNA and of AAK1/GAK mRNA from the same cell. C. Correlation values measured for AAK1 (green) and GAK (orange) at various time points postinfection.
Article Snippet:
Techniques: Infection, Control, Quantitative RT-PCR, Virus, RNA Sequencing, Binding Assay, Gene Expression