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Image Search Results
Journal: Experimental and Therapeutic Medicine
Article Title: Pterostilbene reduces endothelial cell injury in vascular arterial walls by regulating the Nrf2-mediated AMPK/STAT3 pathway in an atherosclerosis rat model
doi: 10.3892/etm.2019.8211
Figure Lengend Snippet: Pts decreases H 2 O 2 -induced cytotoxicity in endothelial cells. (A) Effect of Pts on cell viability in H 2 O 2 -induced endothelial cell cytotoxicity. (B) Oxidative stress injury induces ROS production and NO generation in endothelial cells treated with Pts and PBS. (C) Expression levels of antioxidant proteins SOD, CAT and HO-1 in endothelial cells. (D) Apoptosis of endothelial cells in Pts and control groups. *P<0.05 and **P<0.01 vs. control. CAT, catalase; H 2 O 2 , hydrogen peroxide; HO-1, heme oxygenase-1; NO, nitric oxide; Pts, pterostilbene; ROS, reactive oxygen species; SOD, superoxide dismutase.
Article Snippet:
Techniques: Expressing, Control
Journal: Experimental and Therapeutic Medicine
Article Title: Pterostilbene reduces endothelial cell injury in vascular arterial walls by regulating the Nrf2-mediated AMPK/STAT3 pathway in an atherosclerosis rat model
doi: 10.3892/etm.2019.8211
Figure Lengend Snippet: Pts inhibits the Nrf2-mediated AMPK/STAT3 pathway in endothelial cells. (A) Effect of Pts on Nrf2, AMPK, pAMPK, STAT3 and pSTAT3 levels in endothelial cells. (B) Effects of Nrf2 knockdown on Pts-regulated AMPK, pAMPK, STAT3 and pSTAT3 levels in endothelial cells. **P<0.01. AMPK, 5′ adenosine monophosphate-activated protein kinase; Nrf2, nuclear factor erythroid 2-related factor 2; p, phosphorylated; Pts, pterostilbene; STAT3, signal transducer and activator of transcription 3; ns, not significant; NC, negative control; si, small interfering RNA.
Article Snippet:
Techniques: Knockdown, Negative Control, Small Interfering RNA
Journal: Experimental and Therapeutic Medicine
Article Title: Pterostilbene reduces endothelial cell injury in vascular arterial walls by regulating the Nrf2-mediated AMPK/STAT3 pathway in an atherosclerosis rat model
doi: 10.3892/etm.2019.8211
Figure Lengend Snippet: Effect of si-Nrf2 and Pts on oxidative stress injury and apoptosis in endothelial cells. (A) Effects of Nrf2 knockdown on Pts-regulated SOD, CAT and HO-1 protein expression in endothelial cells. (B) Effects of Nrf2 knockdown on apoptosis in endothelial cells. **P<0.01. CAT, catalase; HO-1, heme oxygenase-1; Nrf2, nuclear factor erythroid 2-related factor 2; Pts, pterostilbene; si, small interfering RNA; SOD, superoxide dismutase; NC, negative control; ns, not significant.
Article Snippet:
Techniques: Knockdown, Expressing, Small Interfering RNA, Negative Control