Journal: Gels

Article Title: Development and Bioavailability Assessment of an Estriol-Containing Vaginal Hydrogel

doi: 10.3390/gels10120823

Figure Lengend Snippet: Results of the biocompatibility on reconstructed human vaginal epithelium measured by MTT ( A ) and LDH tests ( B ). Human vaginal epithelial cells were grown on porous inserts and treated with E3 gel or E3-HPBCD solution from the apical side. Samples for the LDH-release measurements were collected both from the apical side of the inserts and the basal side (indicated by “A” and “B” in the figure legends, respectively). Values are presented as means ± S.D., n = 3. ** and **** represent p < 0.01 and p < 0.0001, respectively, compared to the untreated control, ns: not significant.

Article Snippet: HPBCD was purchased from Cyclolab Ltd. (Budapest, Hungary), E3, sodium chloride, and potassium sorbate were obtained from Merck Ltd. (Budapest, Hungary), zinc sulfate and lactic acid were purchased from Hungaropharma Ltd. (Budapest, Hungary), hydroxyethyl cellulose (HEC; Cellosize QP-30000H, Dow Chemicals Midland, MI, USA), and (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide) (MTT) was obtained from Merck Ltd. (Budapest, Hungary).

Techniques: Control

Journal: Gels

Article Title: Development and Bioavailability Assessment of an Estriol-Containing Vaginal Hydrogel

doi: 10.3390/gels10120823

Figure Lengend Snippet: Permeability of E3 through the reconstructed human vaginal epithelium. E3 gel and E3-HPBCD solution were applied on the apical side of the inserts, and the permeability of E3 was determined after two hours of incubation. Values were expressed as mean ± S.D., n = 4–5. The apparent permeability of E3 was significantly higher from the E3-HPBCD solution compared to the E3 gel. *** represents p < 0.001.

Article Snippet: HPBCD was purchased from Cyclolab Ltd. (Budapest, Hungary), E3, sodium chloride, and potassium sorbate were obtained from Merck Ltd. (Budapest, Hungary), zinc sulfate and lactic acid were purchased from Hungaropharma Ltd. (Budapest, Hungary), hydroxyethyl cellulose (HEC; Cellosize QP-30000H, Dow Chemicals Midland, MI, USA), and (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide) (MTT) was obtained from Merck Ltd. (Budapest, Hungary).

Techniques: Permeability, Incubation

Journal: Pharmaceutics

Article Title: Topical Artocarpus communis Nanoparticles Improved the Water Solubility and Skin Permeation of Raw A. communis Extract, Improving Its Photoprotective Effect

doi: 10.3390/pharmaceutics13091372

Figure Lengend Snippet: The formulation and water solubility, yield, and encapsulation efficiency of AHP.

Article Snippet: On the contrary, the significant enhancement of ACM permeated in AHP contributed to the presence of HPBCD with PVP , indicating that ACM can be delivered via an HPBCD with PVPK30 nanocarrier through the stratum corneum, with the possibility of exerting local effects to prevent skin diseases.

Techniques: Formulation, Solubility, Encapsulation

Journal: Pharmaceutics

Article Title: Topical Artocarpus communis Nanoparticles Improved the Water Solubility and Skin Permeation of Raw A. communis Extract, Improving Its Photoprotective Effect

doi: 10.3390/pharmaceutics13091372

Figure Lengend Snippet: SEM images of ( A ) raw ACM, ( B ) HPBCD, ( C ) PVPK30, ( D ) physical mixture ACM/PVPK30/HPBCD (1:18:10), and ( E ) AHP 1:18:10 and ( F ) particle morphology of AHP 1:18:10 under TEM observation.

Article Snippet: On the contrary, the significant enhancement of ACM permeated in AHP contributed to the presence of HPBCD with PVP , indicating that ACM can be delivered via an HPBCD with PVPK30 nanocarrier through the stratum corneum, with the possibility of exerting local effects to prevent skin diseases.

Techniques:

Journal: Pharmaceutics

Article Title: Topical Artocarpus communis Nanoparticles Improved the Water Solubility and Skin Permeation of Raw A. communis Extract, Improving Its Photoprotective Effect

doi: 10.3390/pharmaceutics13091372

Figure Lengend Snippet: Powder X-ray diffraction patterns of ACM, HPBCD, PVPK30, physical mixture, and AHP.

Article Snippet: On the contrary, the significant enhancement of ACM permeated in AHP contributed to the presence of HPBCD with PVP , indicating that ACM can be delivered via an HPBCD with PVPK30 nanocarrier through the stratum corneum, with the possibility of exerting local effects to prevent skin diseases.

Techniques:

Journal: Pharmaceutics

Article Title: Topical Artocarpus communis Nanoparticles Improved the Water Solubility and Skin Permeation of Raw A. communis Extract, Improving Its Photoprotective Effect

doi: 10.3390/pharmaceutics13091372

Figure Lengend Snippet: Fourier transform infrared (FTIR) spectra of raw ACM, HPBCD, PVPK30, physical mixture, and AHP.

Article Snippet: On the contrary, the significant enhancement of ACM permeated in AHP contributed to the presence of HPBCD with PVP , indicating that ACM can be delivered via an HPBCD with PVPK30 nanocarrier through the stratum corneum, with the possibility of exerting local effects to prevent skin diseases.

Techniques: Fourier Transform Infrared Spectroscopy