Journal: International Journal of Molecular Sciences

Article Title: Small-Molecule Cyclophilin Inhibitors Potently Reduce Platelet Procoagulant Activity

doi: 10.3390/ijms24087163

Figure Lengend Snippet: Small-molecule cyclophilin inhibitors inhibit coagulation induced by procoagulant platelets. ( A ) Whole blood was incubated with 125 µM F759 or F83236, 4 µM CsA before perfusion over a Horm collagen-coated surface in the presence of 6.6 mM CaCl 2 and 3.08 mM MgCl 2 . Shown are representative images after 9 min of top row: DIC images of platelet aggregates; middle row: anti-GpIb-VhH Alexa647 indicating platelets and bottom row: tPA-Alexa488 binding to fibrin. ( B ) Quantification of Δ MFI anti-GpIb-VhH Alexa647 signal during 9 min. ( C ) MFI tPA-Alexa488 over time. ( D ) Quantification of Δ MFI tPA-Alexa488 signal during 9 min. Data represented as mean ± SD of 5–7 separate experiments. * p < 0.05 compared to vehicle by One-Way ANOVA. SMCypIs, small-molecule cyclophilin inhibitors; CsA, Cyclosporin A; tPA, tissue plasminogen activator.

Article Snippet: Images were analyzed for the formation of fibrin via Alexa488 fluorescent intensity by the Image Analysis module within the ZEN2 Pro software (ZEISS Microscopy, Jena, Thüringen, Germany).

Techniques: Coagulation, Incubation, Binding Assay

Journal: Journal of the American Statistical Association

Article Title: Hierarchical network models for exchangeable structured interaction processes

doi: 10.1080/01621459.2021.1896526

Figure Lengend Snippet: L1 distance in local and global receiver distributions given model from Section 3. As αs decreases, heterogeneity among local behavior increases.

Article Snippet: Again, the PY-HVCM leads to an improvement over the Hollywood model and GGP model. Open in a separate window Fig. 8 Histograms of L1 distance between degree distributions of synthetic PPC data and Enron global degree distribution. . 6.3.5.

Techniques:

Journal: Journal of the American Statistical Association

Article Title: Hierarchical network models for exchangeable structured interaction processes

doi: 10.1080/01621459.2021.1896526

Figure Lengend Snippet: Histograms of L1 distance between degree distributions of synthetic PPC data and Enron global degree distribution.

Article Snippet: Again, the PY-HVCM leads to an improvement over the Hollywood model and GGP model. Open in a separate window Fig. 8 Histograms of L1 distance between degree distributions of synthetic PPC data and Enron global degree distribution. . 6.3.5.

Techniques: