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Image Search Results
Journal: Antibodies
Article Title: Asymmetric Fc Engineering for Bispecific Antibodies with Reduced Effector Function
doi: 10.3390/antib6020007
Figure Lengend Snippet: Thermograms of exemplary asymmetric antibody constructs compared to wild-type antibody (WT). ( A ) The thermograms for WT, and AAC2-AAC6. ( B ) The identity of the two transitions in the WT. The first transition corresponds to the unfolding of the CH2 domain, the second transition corresponds to the unfolding of the CH3 + Fab. ( C ) The overlay of a number of samples showing how the CH2 transition of the variants has shifted to a higher Tm value, indicating higher stability.
Article Snippet: Recently, Leaver-Fay et al. [ ] produced new
Techniques: Construct