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Image Search Results
Journal: Frontiers in genetics
Article Title: Exploring the mechanism of YangXue QingNao Wan based on network pharmacology in the treatment of Alzheimer's disease.
doi: 10.3389/fgene.2022.942203
Figure Lengend Snippet: FIGURE 6 YXQNW promotes aβ degradation by regulating the glucose and lipid metabolisms in AD treatment. (A) Summary of liver dysfunction in AD; (B) regulation of the metabolism_role of Adiponectin in regulation of metabolism; (C) regulation of lipid metabolism_RXR-dependent regulation of lipid metabolism via PPAR, RAR, and VDR; (D) regulation of lipid metabolism_regulation of fatty acid synthase activity in hepatocytes. (The red marker is the target of YXQNW); (E) YXQNW may promote Aβ degradation in hepatic stellate cells. Rat hepatic stellate cell HST-T6 was incubated with different concentrations of YXQNW or negative control drug Memantine (100 μM). After 48 h of incubation, add Aβ1-42 (1 μM) into the cell except blank control group for 1 h of ingestion. Cellular Aβ accumulation was detected by an Aβ ELISA kit. ***p < 0.001 is compared with the Ctrl group; ##p < 0.01, ###p < 0.001 is compared with the Model group.
Article Snippet:
Techniques: Activity Assay, Marker, Incubation, Negative Control, Control, Enzyme-linked Immunosorbent Assay