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Image Search Results
Journal: Materials today. Bio
Article Title: Cyclic stretch induced epigenetic activation of periodontal ligament cells.
doi: 10.1016/j.mtbio.2024.101050
Figure Lengend Snippet: Fig. 8. Mechanical stretch regulates reactive oxygen species (ROS) resistance and lineage specification in periodontal ligament (PDL) cells. Mechanical stretch led to cell alignment via actin and tubulin reorganization, which increased Histone 3 acetylation levels. These epigenetic modifications enhanced gene transcription and provided ROS resistance by promoting an open chromatin state. Additionally, mechanical stretch affected lineage specification, inducing PDL cells into the osteoclast and osteoblast pathways. H3Ace; histone 3 Acetylation, H3K9me3; histone H3 lysine 9 trimethylation, Ac; acetylation, Me; methylation.
Article Snippet: The following primary antibodies were used: Rabbit Antiacetyl-Histone H3 Antibody (H3Ace; #06-599, Sigma-Aldrich),
Techniques: Methylation