gs39783 Search Results


gs 39783  (MuseChem Chemicals)
N/A
GS39783（Cat No.:R042422）is a selective antagonist of the GABA-B receptor, a G-protein-coupled receptor involved in inhibitory neurotransmission in the central nervous system. By blocking the activity of this receptor, GS39783 has been investigated for its potential
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gs 39783  (1PlusChem LLC)
N/A
GS 39783
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gs 39783  (Tocris)
93
Tocris gs 39783
Gs 39783, supplied by Tocris, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/gs39783/GS+39783/pmc12138688-77-79-81
Average 93 stars, based on 1 article reviews
gs 39783 - by Bioz Stars, 2026-09
93/100 stars
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n n dicyclopentyl 2 methylsulfanyl 5 nitro pyrimidine 4 6 diamine  (Tocris)
99
Tocris n n dicyclopentyl 2 methylsulfanyl 5 nitro pyrimidine 4 6 diamine
N N Dicyclopentyl 2 Methylsulfanyl 5 Nitro Pyrimidine 4 6 Diamine, supplied by Tocris, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/gs39783/GS+39783/pmc03473327-53-0-3
Average 99 stars, based on 1 article reviews
n n dicyclopentyl 2 methylsulfanyl 5 nitro pyrimidine 4 6 diamine - by Bioz Stars, 2026-09
99/100 stars
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gs39783  (Axon Medchem LLC)
90
Axon Medchem LLC gs39783
Diagrams showing the effects of 10 and 30 mg/kg <t>GS39783</t> on the percent time spent in the bright area of the light–dark box. There were no effects of GS39783 if all animals were analyzed together ( A ). For further analysis, mice were then grouped based on their basal anxiety, i.e., their behavior after vehicle ( B ). If mice were grouped for basal anxiety, 30 mg/kg GS39783 had anxiolytic-like effects in the mice of the most anxious group but not in the average and non-anxious groups ( C ). Furthermore, the individual effects of 30 mg/kg GS39783 were correlated with the behavior after vehicle ( D ). * p < 0.05, comparisons as indicated. Sexes were pooled since there were no effects of sex (numbers in the bars represent group sizes for males (top) and females (bottom)). Y-axis scale and units in panels ( B , C ) are the same as in panel ( A ).
Gs39783, supplied by Axon Medchem LLC, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/gs39783/gs39783/pmc08878184-155-0-10
Average 90 stars, based on 1 article reviews
gs39783 - by Bioz Stars, 2026-09
90/100 stars
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gs39783  (CH Instruments)
90
CH Instruments gs39783
Diagrams showing the effects of 10 and 30 mg/kg <t>GS39783</t> on the percent time spent in the bright area of the light–dark box. There were no effects of GS39783 if all animals were analyzed together ( A ). For further analysis, mice were then grouped based on their basal anxiety, i.e., their behavior after vehicle ( B ). If mice were grouped for basal anxiety, 30 mg/kg GS39783 had anxiolytic-like effects in the mice of the most anxious group but not in the average and non-anxious groups ( C ). Furthermore, the individual effects of 30 mg/kg GS39783 were correlated with the behavior after vehicle ( D ). * p < 0.05, comparisons as indicated. Sexes were pooled since there were no effects of sex (numbers in the bars represent group sizes for males (top) and females (bottom)). Y-axis scale and units in panels ( B , C ) are the same as in panel ( A ).
Gs39783, supplied by CH Instruments, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/gs39783/gs39783/pm21423431-72-14-21
Average 90 stars, based on 1 article reviews
gs39783 - by Bioz Stars, 2026-09
90/100 stars
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gs 39783  (BOC Sciences)
N/A
GS 39783 is an allosteric positive modulator of GABAB receptors, decreases cocaine self-administration, blocks the rewarding properties of nicotine and produces anxiolytic-like activity without the side effects associated with baclofen or benzodiazepines.
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gs 39783-d8  (Toronto Research Chemicals)
N/A
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gs 39783  (Cayman Chemical)
N/A
GS 39783
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gs 39783  (TargetMol)
N/A
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gs39783  (MedChemExpress)
N/A
GS39783 is a positive allosteric modulator (PAM) of GABABR. Positive modulation of the GABABR can be used for the research of Nicotine addiction.
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gs 39783  (Toronto Research Chemicals)
N/A
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Image Search Results


Diagrams showing the effects of 10 and 30 mg/kg GS39783 on the percent time spent in the bright area of the light–dark box. There were no effects of GS39783 if all animals were analyzed together ( A ). For further analysis, mice were then grouped based on their basal anxiety, i.e., their behavior after vehicle ( B ). If mice were grouped for basal anxiety, 30 mg/kg GS39783 had anxiolytic-like effects in the mice of the most anxious group but not in the average and non-anxious groups ( C ). Furthermore, the individual effects of 30 mg/kg GS39783 were correlated with the behavior after vehicle ( D ). * p < 0.05, comparisons as indicated. Sexes were pooled since there were no effects of sex (numbers in the bars represent group sizes for males (top) and females (bottom)). Y-axis scale and units in panels ( B , C ) are the same as in panel ( A ).

Journal: Pharmaceuticals

Article Title: Anxiolytic-like Effects of the Positive GABA B Receptor Modulator GS39783 Correlate with Mice’s Individual Basal Anxiety and Stress Reactivity

doi: 10.3390/ph15020233

Figure Lengend Snippet: Diagrams showing the effects of 10 and 30 mg/kg GS39783 on the percent time spent in the bright area of the light–dark box. There were no effects of GS39783 if all animals were analyzed together ( A ). For further analysis, mice were then grouped based on their basal anxiety, i.e., their behavior after vehicle ( B ). If mice were grouped for basal anxiety, 30 mg/kg GS39783 had anxiolytic-like effects in the mice of the most anxious group but not in the average and non-anxious groups ( C ). Furthermore, the individual effects of 30 mg/kg GS39783 were correlated with the behavior after vehicle ( D ). * p < 0.05, comparisons as indicated. Sexes were pooled since there were no effects of sex (numbers in the bars represent group sizes for males (top) and females (bottom)). Y-axis scale and units in panels ( B , C ) are the same as in panel ( A ).

Article Snippet: GS39783, a positive allosteric GABA-B receptor modulator was purchased from Axon MedChem BV (ID: 1820; Groningen, The Netherlands), Tween-80 was purchased from Sigma-Aldrich Chemie (P5188; Taufkirchen, Germany).

Techniques:

Diagrams showing the effects of 10 and 30 mg/kg GS39783 on the percent time spent in the bright area of the light–dark box and on corticosterone plasma levels 10 days after stress by exposure to electric stimuli. There were no main effects of GS39783 treatment ( A ). However, the change of light–dark box behavior after stress was very variable ( B ). Therefore, mice were grouped according to their stress response ( C ). In the high stress-responsive group, GS39783 treatment significantly increased percent time spent in the bright area of the light–dark box. GS39783 treatment had no effects in the groups with average or low stress responsiveness. Of note, individual stress responsiveness was correlated with the effects of 30 mg/kg GS39783 ( D ). Corticosterone plasma levels were increased after the stress as well as after the light–dark box tests but were not affected by stress responsiveness and treatment ( E ). ## p < 0.01, * p < 0.05, comparisons as indicated. Sexes were pooled since there were no effects of sex (numbers in the bars represent group sizes for males (top) and females (bottom)).

Journal: Pharmaceuticals

Article Title: Anxiolytic-like Effects of the Positive GABA B Receptor Modulator GS39783 Correlate with Mice’s Individual Basal Anxiety and Stress Reactivity

doi: 10.3390/ph15020233

Figure Lengend Snippet: Diagrams showing the effects of 10 and 30 mg/kg GS39783 on the percent time spent in the bright area of the light–dark box and on corticosterone plasma levels 10 days after stress by exposure to electric stimuli. There were no main effects of GS39783 treatment ( A ). However, the change of light–dark box behavior after stress was very variable ( B ). Therefore, mice were grouped according to their stress response ( C ). In the high stress-responsive group, GS39783 treatment significantly increased percent time spent in the bright area of the light–dark box. GS39783 treatment had no effects in the groups with average or low stress responsiveness. Of note, individual stress responsiveness was correlated with the effects of 30 mg/kg GS39783 ( D ). Corticosterone plasma levels were increased after the stress as well as after the light–dark box tests but were not affected by stress responsiveness and treatment ( E ). ## p < 0.01, * p < 0.05, comparisons as indicated. Sexes were pooled since there were no effects of sex (numbers in the bars represent group sizes for males (top) and females (bottom)).

Article Snippet: GS39783, a positive allosteric GABA-B receptor modulator was purchased from Axon MedChem BV (ID: 1820; Groningen, The Netherlands), Tween-80 was purchased from Sigma-Aldrich Chemie (P5188; Taufkirchen, Germany).

Techniques: Clinical Proteomics

Extracted ion chromatograms of mass-to-charge ratio ( m / z ) 338.1640 corresponding to [M+H] + ion of GS39783 in positive mode electrospray (ESI) from ( A ) mouse brain extract and ( B ) plasma sample. Peak areas were used for quantitative purposes. Note the values measured in the peak apex ( m / z 338.1647 and m / z 338.1644).

Journal: Pharmaceuticals

Article Title: Anxiolytic-like Effects of the Positive GABA B Receptor Modulator GS39783 Correlate with Mice’s Individual Basal Anxiety and Stress Reactivity

doi: 10.3390/ph15020233

Figure Lengend Snippet: Extracted ion chromatograms of mass-to-charge ratio ( m / z ) 338.1640 corresponding to [M+H] + ion of GS39783 in positive mode electrospray (ESI) from ( A ) mouse brain extract and ( B ) plasma sample. Peak areas were used for quantitative purposes. Note the values measured in the peak apex ( m / z 338.1647 and m / z 338.1644).

Article Snippet: GS39783, a positive allosteric GABA-B receptor modulator was purchased from Axon MedChem BV (ID: 1820; Groningen, The Netherlands), Tween-80 was purchased from Sigma-Aldrich Chemie (P5188; Taufkirchen, Germany).

Techniques: Clinical Proteomics

Summary of the GS39783 levels found in plasma and brain tissue of selected animals administered with an intraperitoneal dose of 30 mg/kg.

Journal: Pharmaceuticals

Article Title: Anxiolytic-like Effects of the Positive GABA B Receptor Modulator GS39783 Correlate with Mice’s Individual Basal Anxiety and Stress Reactivity

doi: 10.3390/ph15020233

Figure Lengend Snippet: Summary of the GS39783 levels found in plasma and brain tissue of selected animals administered with an intraperitoneal dose of 30 mg/kg.

Article Snippet: GS39783, a positive allosteric GABA-B receptor modulator was purchased from Axon MedChem BV (ID: 1820; Groningen, The Netherlands), Tween-80 was purchased from Sigma-Aldrich Chemie (P5188; Taufkirchen, Germany).

Techniques: Clinical Proteomics