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Image Search Results
Journal: Cancer Cell International
Article Title: The cholesterol metabolite 27-hydroxycholesterol stimulates cell proliferation via ERβ in prostate cancer cells
doi: 10.1186/s12935-017-0422-x
Figure Lengend Snippet: 27-OHC stimulates cell proliferation via ER. Cell proliferation assay in LNCaP ( a ) and PC3 ( b ) cells demonstrates an attenuation of 27-OHC-induced cell proliferation with the ER inhibitor ICI 182,780 (fulvestrant). Cells were treated with 1 µM 27-OHC, 2 nM of E2 and 10 µM ICI 182,780. Readings were recorded 48 h after treatment with 27-OHC. Data is expressed as mean ± SEM. **p < 0.01; ***p < 0.001 versus controls, ### p < 0.001 versus 27-OHC only treatment
Article Snippet: 27-Hydroxycholesterol was purchased from Santa Cruz Biotechnologies (Dallas, TX), docetaxel, 4-[2-phenyl-5,7-bis(trifluoromethyl) pyrazolo[1,5-a]pyrimidin-3-yl]phenol (PHTPP) and
Techniques: Proliferation Assay