Journal: Journal of Veterinary Science

Article Title: Effects of feed intake and water hardness on fluralaner pharmacokinetics in layer chickens

doi: 10.4142/jvs.22048

Figure Lengend Snippet: Plasma fluralaner validation results in LC-MS/MS analysis

Article Snippet: The reference standard of fluralaner (99.83%, 864731-61-3) was purchased from MedChem Express (China).

Techniques:

Journal: Journal of Veterinary Science

Article Title: Effects of feed intake and water hardness on fluralaner pharmacokinetics in layer chickens

doi: 10.4142/jvs.22048

Figure Lengend Snippet: Pharmacokinetic profile of fluralaner. Data are presented as means and standard deviation of the mean (n = 8).

Article Snippet: The reference standard of fluralaner (99.83%, 864731-61-3) was purchased from MedChem Express (China).

Techniques: Standard Deviation

Journal: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology

Article Title: Study on the effect of an ion channel inhibitor “Fluralaner” on Echinococcus granulosus protoscolices and metacestode layers in vitro

doi: 10.1007/s12639-020-01224-6

Figure Lengend Snippet: Percentage of viable protoscolices after exposure to different doses of fluralaner at 1 h, 6 h and 24 h time interval

Article Snippet: A fluralaner pack size of 25 mg was purchased from TargetMol (Cat. No. T5330).

Techniques:

Journal: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology

Article Title: Study on the effect of an ion channel inhibitor “Fluralaner” on Echinococcus granulosus protoscolices and metacestode layers in vitro

doi: 10.1007/s12639-020-01224-6

Figure Lengend Snippet: Morphological alterations of E. granulosus protoscolices after 1 h incubation with different doses of fluralaner, stained with H & E. a–c Examples of control PSCs; showed normal intact PSCs, with visible hooks and calcareous corpuscles (Cr). d–f Treated PSCs with 12.5 ug/ml; showed vacuoles formation, multiple deformities (arrow). G-I: Treated PSCs with 100 ug/ml; showed detachment of cuticle (de) and complete loss of integrity (loss of hooks, scolex, and suction cup) (× 400)

Article Snippet: A fluralaner pack size of 25 mg was purchased from TargetMol (Cat. No. T5330).

Techniques: Incubation, Staining

Journal: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology

Article Title: Study on the effect of an ion channel inhibitor “Fluralaner” on Echinococcus granulosus protoscolices and metacestode layers in vitro

doi: 10.1007/s12639-020-01224-6

Figure Lengend Snippet: TEM of E. granulosus protoscolices after 1-h incubation with different doses of fluralaner compared to control protoscolices. Figure a-c Control protoscolices showing the distinct features of the protoscolices such as; Germinal layer (GL) that contain numerous cell types, Tegumental Layer (Teg), projection of intact microtriches (Mt) (arrows) into Laminated layer (LL). Figure d–f Treated protoscolices showing morphological changes as sheading of microtriches (arrows), the occurrence of lipid droplets (Ld) and vacuolation (Vac). A (x7500), B&C (x4000), D (x3000), E (x2000), F (x5000)

Article Snippet: A fluralaner pack size of 25 mg was purchased from TargetMol (Cat. No. T5330).

Techniques: Incubation

Journal: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology

Article Title: Study on the effect of an ion channel inhibitor “Fluralaner” on Echinococcus granulosus protoscolices and metacestode layers in vitro

doi: 10.1007/s12639-020-01224-6

Figure Lengend Snippet: TEM in E.granulosus camel metacestode layers after 1-h incubation with different doses of fluralaner compared to control. a Control sample showing intact germinal layer and the characteristic multicellular structure. b, c treated metacestode showing detachment of germinal layer with only cellular debris remaining and the detachment of tegument (arrow) from the laminated layer (LL). d, e: treated metacestode showing complete disappearance of the germinal layer and some destruction in the laminated layer (arrow). A (x7500), B (x4000), C (x3000), D&E (x1500)

Article Snippet: A fluralaner pack size of 25 mg was purchased from TargetMol (Cat. No. T5330).

Techniques: Incubation

Journal: Parasites & vectors

Article Title: Topical, contact, and oral susceptibility of adult Culicoides biting midges (Diptera: Ceratopogonidae) to fluralaner.

doi: 10.1186/s13071-023-05899-7

Figure Lengend Snippet: Fig. 1 Average mortality after contact exposure to fluralaner at concentrations of 0–100 mg/ml for Culicoides sonorensis at 1 h (n = 777 total individuals tested) and 24 h (n = 773 total individuals tested); 1 h is represented by light blue and 24 h by dark blue. Error bars represent standard deviation and asterisks represent significant differences between control (concentration = 0 mg/ml) and treatment at each concentration (***P < 0.0005). Concentrations not marked with asterisks did not differ significantly between control and treatment

Article Snippet: One hundred milligrams of technical grade fluralaner (BOCSCI Inc., Shirley, NY) was formulated in either 1 ml HPLCgrade acetone (contact and topical trials) or DMSO (oral trials) and then serially diluted to the appropriate concentration.

Techniques: Standard Deviation, Control, Concentration Assay

Journal: Parasites & vectors

Article Title: Topical, contact, and oral susceptibility of adult Culicoides biting midges (Diptera: Ceratopogonidae) to fluralaner.

doi: 10.1186/s13071-023-05899-7

Figure Lengend Snippet: Fig. 2 Average mortality after topical exposure to fluralaner at concentrations of 0–10 mg/ml for Culicoides sonorensis at 1 h (n = 480 total individuals tested) and 24 h (n = 475 total individuals tested); 1 h is represented by light blue and 24 h by dark blue. Error bars represent standard deviation, and asterisks represent significant differences between control (concentration = 0 mg/ml) and treatment at each concentration (***P < 0.0005). Concentrations not marked with asterisks did not differ significantly between control and treatment

Article Snippet: One hundred milligrams of technical grade fluralaner (BOCSCI Inc., Shirley, NY) was formulated in either 1 ml HPLCgrade acetone (contact and topical trials) or DMSO (oral trials) and then serially diluted to the appropriate concentration.

Techniques: Standard Deviation, Control, Concentration Assay

Journal: Parasites & vectors

Article Title: Topical, contact, and oral susceptibility of adult Culicoides biting midges (Diptera: Ceratopogonidae) to fluralaner.

doi: 10.1186/s13071-023-05899-7

Figure Lengend Snippet: Fig. 3 Average mortality after oral exposure to fluralaner at concentrations of 0–1000 ng/ml for Culicoides sonorensis at 1 h (n = 144 total individuals tested) and 24 h (n = 144 total individuals tested); 1 h is represented by light blue and 24 h by dark blue. Error bars represent standard deviation and asterisks represent significant differences between control (concentration = 0 ng/ml) and treatment at each concentration (***P < 0.0005). Concentrations not marked with asterisks did not differ significantly between control and treatment

Article Snippet: One hundred milligrams of technical grade fluralaner (BOCSCI Inc., Shirley, NY) was formulated in either 1 ml HPLCgrade acetone (contact and topical trials) or DMSO (oral trials) and then serially diluted to the appropriate concentration.

Techniques: Standard Deviation, Control, Concentration Assay

Journal: Parasites & vectors

Article Title: Topical, contact, and oral susceptibility of adult Culicoides biting midges (Diptera: Ceratopogonidae) to fluralaner.

doi: 10.1186/s13071-023-05899-7

Figure Lengend Snippet: Fig. 1 Average mortality after contact exposure to fluralaner at concentrations of 0–100 mg/ml for Culicoides sonorensis at 1 h (n = 777 total individuals tested) and 24 h (n = 773 total individuals tested); 1 h is represented by light blue and 24 h by dark blue. Error bars represent standard deviation and asterisks represent significant differences between control (concentration = 0 mg/ml) and treatment at each concentration (***P < 0.0005). Concentrations not marked with asterisks did not differ significantly between control and treatment

Article Snippet: Selleckchem: Fluralaner safety data sheet.

Techniques: Standard Deviation, Control, Concentration Assay

Journal: Parasites & vectors

Article Title: Topical, contact, and oral susceptibility of adult Culicoides biting midges (Diptera: Ceratopogonidae) to fluralaner.

doi: 10.1186/s13071-023-05899-7

Figure Lengend Snippet: Fig. 2 Average mortality after topical exposure to fluralaner at concentrations of 0–10 mg/ml for Culicoides sonorensis at 1 h (n = 480 total individuals tested) and 24 h (n = 475 total individuals tested); 1 h is represented by light blue and 24 h by dark blue. Error bars represent standard deviation, and asterisks represent significant differences between control (concentration = 0 mg/ml) and treatment at each concentration (***P < 0.0005). Concentrations not marked with asterisks did not differ significantly between control and treatment

Article Snippet: Selleckchem: Fluralaner safety data sheet.

Techniques: Standard Deviation, Control, Concentration Assay

Journal: Parasites & vectors

Article Title: Topical, contact, and oral susceptibility of adult Culicoides biting midges (Diptera: Ceratopogonidae) to fluralaner.

doi: 10.1186/s13071-023-05899-7

Figure Lengend Snippet: Fig. 3 Average mortality after oral exposure to fluralaner at concentrations of 0–1000 ng/ml for Culicoides sonorensis at 1 h (n = 144 total individuals tested) and 24 h (n = 144 total individuals tested); 1 h is represented by light blue and 24 h by dark blue. Error bars represent standard deviation and asterisks represent significant differences between control (concentration = 0 ng/ml) and treatment at each concentration (***P < 0.0005). Concentrations not marked with asterisks did not differ significantly between control and treatment

Article Snippet: Selleckchem: Fluralaner safety data sheet.

Techniques: Standard Deviation, Control, Concentration Assay

Journal: Parasites & Vectors

Article Title: In-home assessment of either topical fluralaner or topical selamectin for flea control in naturally infested cats in West Central Florida, USA

doi: 10.1186/s13071-018-2995-1

Figure Lengend Snippet: Flea counts on naturally infested cats in households in Florida before and after treatment with either a single topical dose of fluralaner or three consecutive monthly doses of selamectin

Article Snippet: In treatment Group 1 cats were administered a topical fluralaner solution (Bravecto® Topical Solution; Merck Animal Health, Madison, NJ, USA) at the recommended labeled dose (minimum 40 mg/kg).

Techniques: Control

Journal: Parasites & Vectors

Article Title: In-home assessment of either topical fluralaner or topical selamectin for flea control in naturally infested cats in West Central Florida, USA

doi: 10.1186/s13071-018-2995-1

Figure Lengend Snippet: Flea counts on naturally infested dogs in households in Florida before and after treatment with a single oral dose of fluralaner or three consecutive monthly doses of sarolaner

Article Snippet: In treatment Group 1 cats were administered a topical fluralaner solution (Bravecto® Topical Solution; Merck Animal Health, Madison, NJ, USA) at the recommended labeled dose (minimum 40 mg/kg).

Techniques: Control

Journal: Parasites & Vectors

Article Title: In-home assessment of either topical fluralaner or topical selamectin for flea control in naturally infested cats in West Central Florida, USA

doi: 10.1186/s13071-018-2995-1

Figure Lengend Snippet: Fleas caught in intermittent-light flea traps in naturally infested homes in Florida before and after treatment of all dogs and cats in the homes with either a single administration of fluralaner or three consecutive monthly administrations of sarolaner (dogs) and selamectin (cats)

Article Snippet: In treatment Group 1 cats were administered a topical fluralaner solution (Bravecto® Topical Solution; Merck Animal Health, Madison, NJ, USA) at the recommended labeled dose (minimum 40 mg/kg).

Techniques: Control

Journal: Parasites & Vectors

Article Title: In-home assessment of either topical fluralaner or topical selamectin for flea control in naturally infested cats in West Central Florida, USA

doi: 10.1186/s13071-018-2995-1

Figure Lengend Snippet: Owner assessment of pruritus using a visual analogue scale (PVAS) for cats in homes naturally infested with fleas before and after treatment with either a single topical dose of fluralaner or three consecutive topical treatments with selamectin

Article Snippet: In treatment Group 1 cats were administered a topical fluralaner solution (Bravecto® Topical Solution; Merck Animal Health, Madison, NJ, USA) at the recommended labeled dose (minimum 40 mg/kg).

Techniques:

Journal: Parasites & Vectors

Article Title: In-home assessment of either topical fluralaner or topical selamectin for flea control in naturally infested cats in West Central Florida, USA

doi: 10.1186/s13071-018-2995-1

Figure Lengend Snippet: Assessment of dermatologic lesions using a feline allergic dermatitis (SCORFAD) severity scale for cats naturally infested with fleas in homes in Florida and treated with either a single topical dose of fluralaner or three consecutive monthly doses of selamectin

Article Snippet: In treatment Group 1 cats were administered a topical fluralaner solution (Bravecto® Topical Solution; Merck Animal Health, Madison, NJ, USA) at the recommended labeled dose (minimum 40 mg/kg).

Techniques:

Journal: Poultry Science

Article Title: Pharmacokinetics of intravenously and trans-dermally administered fluralaner in healthy laying shaver hens: fluralaner in chickens

doi: 10.1016/j.psj.2023.103362

Figure Lengend Snippet: Physicochemical properties and structure of fluralaner.

Article Snippet: Fluralaner was purchased from Cayman chemical (Ann Arbor, MI).

Techniques: Molecular Weight, Solubility

Journal: Poultry Science

Article Title: Pharmacokinetics of intravenously and trans-dermally administered fluralaner in healthy laying shaver hens: fluralaner in chickens

doi: 10.1016/j.psj.2023.103362

Figure Lengend Snippet: Intraday precision and accuracy of analytical method.

Article Snippet: Fluralaner was purchased from Cayman chemical (Ann Arbor, MI).

Techniques: Concentration Assay, Standard Deviation

Journal: Poultry Science

Article Title: Pharmacokinetics of intravenously and trans-dermally administered fluralaner in healthy laying shaver hens: fluralaner in chickens

doi: 10.1016/j.psj.2023.103362

Figure Lengend Snippet: Interday precision and accuracy of analytical method

Article Snippet: Fluralaner was purchased from Cayman chemical (Ann Arbor, MI).

Techniques: Concentration Assay, Standard Deviation

Journal: Poultry Science

Article Title: Pharmacokinetics of intravenously and trans-dermally administered fluralaner in healthy laying shaver hens: fluralaner in chickens

doi: 10.1016/j.psj.2023.103362

Figure Lengend Snippet: Plasma fluralaner concentration (mean ± standard deviation, µg/mL) versus time curve (hours) after single intravenous (IV, 0.5 mg/kg) and transdermal (TDRM, 58.7 mg/kg) administration of fluralaner in shaver hens. The dotted line represents the lethal concentration (LC) 50 for bed bugs ( Cimex lectularius ): 0.0153 µg/mL . Samples above the limit of quantification (0.005 µg/mL) were included in this data.

Article Snippet: Fluralaner was purchased from Cayman chemical (Ann Arbor, MI).

Techniques: Concentration Assay, Standard Deviation

Journal: Poultry Science

Article Title: Pharmacokinetics of intravenously and trans-dermally administered fluralaner in healthy laying shaver hens: fluralaner in chickens

doi: 10.1016/j.psj.2023.103362

Figure Lengend Snippet: Plasma fluralaner concentration (mean ± standard deviation, µg/mL) versus time curve (hours) for first 50 h after single intravenous (IV, 0.5 mg/kg) and transdermal (TDRM, 58.7 mg/kg) administration of fluralaner in shaver hens. The dotted line represents the lethal concentration (LC) 50 for bed bugs ( Cimex lectularius ): 0.0153 µg/mL . Samples above the limit of quantification (0.005 µg/mL) were included in this data.

Article Snippet: Fluralaner was purchased from Cayman chemical (Ann Arbor, MI).

Techniques: Concentration Assay, Standard Deviation