fitc a Search Results


fitc-aβ 42  (AnaSpec)
90
AnaSpec fitc-aβ 42
<t>FITC-labeled</t> <t>A</t> β 42 enters the brain parenchyma, shows selective affinity for pyramidal neurons, and is internalized within these cells . A–D) In the cerebral cortex of mice injected with PT and FITC-Aβ 42 , FITC-Aβ 42 leaks out from blood vessels (white dashed circle in A) and is selectively internalized in pyramidal neurons (B–D). In neurons, FITC-Aβ 42 was localized within numerous discrete granules in the neuronal perikaryon, suggesting that cell surface-bound FITC-Aβ 42 is internalized and accumulates within a membrane-enclosed compartment. E, F) Background fluorescence in the cerebral cortex of mice not exposed to FITC-Aβ42 [i.e., PT-Sal (E) and Sal-only (F)] mice. No punctate immunofluorescence like FITC-Aβ 42 was seen in PT-Sal (E) and Sal-only (F) mice. PN, Pyramidal neurons: BV, blood vessel; Cap, capillary; PT, Pertussis toxin; Ctx, cerebral cortex. Scale bar = 50μm.
Fitc Aβ 42, supplied by AnaSpec, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/fitc+a/fitc+a+%CE%B2+1+42/pmc10977376-42-0-5
Average 90 stars, based on 1 article reviews
fitc-aβ 42 - by Bioz Stars, 2026-11
90/100 stars
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fitc–a 1-42  (Bachem)
90
Bachem fitc–a 1-42
<t>FITC-labeled</t> <t>A</t> β 42 enters the brain parenchyma, shows selective affinity for pyramidal neurons, and is internalized within these cells . A–D) In the cerebral cortex of mice injected with PT and FITC-Aβ 42 , FITC-Aβ 42 leaks out from blood vessels (white dashed circle in A) and is selectively internalized in pyramidal neurons (B–D). In neurons, FITC-Aβ 42 was localized within numerous discrete granules in the neuronal perikaryon, suggesting that cell surface-bound FITC-Aβ 42 is internalized and accumulates within a membrane-enclosed compartment. E, F) Background fluorescence in the cerebral cortex of mice not exposed to FITC-Aβ42 [i.e., PT-Sal (E) and Sal-only (F)] mice. No punctate immunofluorescence like FITC-Aβ 42 was seen in PT-Sal (E) and Sal-only (F) mice. PN, Pyramidal neurons: BV, blood vessel; Cap, capillary; PT, Pertussis toxin; Ctx, cerebral cortex. Scale bar = 50μm.
Fitc–A 1 42, supplied by Bachem, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/fitc+a/fitc+a+1+42/10__1523_slash_jneurosci__3268___10__2011-98-32-35
Average 90 stars, based on 1 article reviews
fitc–a 1-42 - by Bioz Stars, 2026-11
90/100 stars
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fitc-labeled a 42 fitc-a 42  (Bachem)
90
Bachem fitc-labeled a 42 fitc-a 42
<t>FITC-labeled</t> <t>A</t> β 42 enters the brain parenchyma, shows selective affinity for pyramidal neurons, and is internalized within these cells . A–D) In the cerebral cortex of mice injected with PT and FITC-Aβ 42 , FITC-Aβ 42 leaks out from blood vessels (white dashed circle in A) and is selectively internalized in pyramidal neurons (B–D). In neurons, FITC-Aβ 42 was localized within numerous discrete granules in the neuronal perikaryon, suggesting that cell surface-bound FITC-Aβ 42 is internalized and accumulates within a membrane-enclosed compartment. E, F) Background fluorescence in the cerebral cortex of mice not exposed to FITC-Aβ42 [i.e., PT-Sal (E) and Sal-only (F)] mice. No punctate immunofluorescence like FITC-Aβ 42 was seen in PT-Sal (E) and Sal-only (F) mice. PN, Pyramidal neurons: BV, blood vessel; Cap, capillary; PT, Pertussis toxin; Ctx, cerebral cortex. Scale bar = 50μm.
Fitc Labeled A 42 Fitc A 42, supplied by Bachem, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/fitc+a/fitc+labeled+a+42+fitc+a+42/10__1074_slash_jbc__m112__355156-101-0-12
Average 90 stars, based on 1 article reviews
fitc-labeled a 42 fitc-a 42 - by Bioz Stars, 2026-11
90/100 stars
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fitc-a-basic000 filter  (IDEX)
90
IDEX fitc-a-basic000 filter
<t>FITC-labeled</t> <t>A</t> β 42 enters the brain parenchyma, shows selective affinity for pyramidal neurons, and is internalized within these cells . A–D) In the cerebral cortex of mice injected with PT and FITC-Aβ 42 , FITC-Aβ 42 leaks out from blood vessels (white dashed circle in A) and is selectively internalized in pyramidal neurons (B–D). In neurons, FITC-Aβ 42 was localized within numerous discrete granules in the neuronal perikaryon, suggesting that cell surface-bound FITC-Aβ 42 is internalized and accumulates within a membrane-enclosed compartment. E, F) Background fluorescence in the cerebral cortex of mice not exposed to FITC-Aβ42 [i.e., PT-Sal (E) and Sal-only (F)] mice. No punctate immunofluorescence like FITC-Aβ 42 was seen in PT-Sal (E) and Sal-only (F) mice. PN, Pyramidal neurons: BV, blood vessel; Cap, capillary; PT, Pertussis toxin; Ctx, cerebral cortex. Scale bar = 50μm.
Fitc A Basic000 Filter, supplied by IDEX, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/fitc+a/fitc+a+basic000+filter/pm35238926-68-34-37
Average 90 stars, based on 1 article reviews
fitc-a-basic000 filter - by Bioz Stars, 2026-11
90/100 stars
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influenza a h1n1 hemagglutinin antibody [fitc] - (a/ussr/90/1977)  (Novus Biologicals)
N/A
The Influenza A H1N1 Hemagglutinin Antibody [FITC] - (A/USSR/90/1977) from Novus is a Influenza A H1N1 Hemagglutinin antibody to Influenza A H1N1 Hemagglutinin. This antibody reacts with Influenza A Virus H1N1. The Influenza A H1N1
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influenza a h5n1 hemagglutinin antibody (2b7) [fitc] - (a/vietnam/hn31242/2007)  (Novus Biologicals)
N/A
The Influenza A H5N1 Hemagglutinin Antibody (2B7) [FITC] - (A/Vietnam/HN31242/2007) from Novus is a Influenza A H5N1 Hemagglutinin antibody to Influenza A H5N1 Hemagglutinin. This antibody reacts with Influenza A Virus H5N1. The Influenza A
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Image Search Results


FITC-labeled A β 42 enters the brain parenchyma, shows selective affinity for pyramidal neurons, and is internalized within these cells . A–D) In the cerebral cortex of mice injected with PT and FITC-Aβ 42 , FITC-Aβ 42 leaks out from blood vessels (white dashed circle in A) and is selectively internalized in pyramidal neurons (B–D). In neurons, FITC-Aβ 42 was localized within numerous discrete granules in the neuronal perikaryon, suggesting that cell surface-bound FITC-Aβ 42 is internalized and accumulates within a membrane-enclosed compartment. E, F) Background fluorescence in the cerebral cortex of mice not exposed to FITC-Aβ42 [i.e., PT-Sal (E) and Sal-only (F)] mice. No punctate immunofluorescence like FITC-Aβ 42 was seen in PT-Sal (E) and Sal-only (F) mice. PN, Pyramidal neurons: BV, blood vessel; Cap, capillary; PT, Pertussis toxin; Ctx, cerebral cortex. Scale bar = 50μm.

Journal: Journal of Alzheimer's Disease

Article Title: A Chronic Increase in Blood-Brain Barrier Permeability Facilitates Intraneuronal Deposition of Exogenous Bloodborne Amyloid-Beta 1–42 Peptide in the Brain and Leads to Alzheimer’s Disease-Relevant Cognitive Changes in a Mouse Model

doi: 10.3233/JAD-231028

Figure Lengend Snippet: FITC-labeled A β 42 enters the brain parenchyma, shows selective affinity for pyramidal neurons, and is internalized within these cells . A–D) In the cerebral cortex of mice injected with PT and FITC-Aβ 42 , FITC-Aβ 42 leaks out from blood vessels (white dashed circle in A) and is selectively internalized in pyramidal neurons (B–D). In neurons, FITC-Aβ 42 was localized within numerous discrete granules in the neuronal perikaryon, suggesting that cell surface-bound FITC-Aβ 42 is internalized and accumulates within a membrane-enclosed compartment. E, F) Background fluorescence in the cerebral cortex of mice not exposed to FITC-Aβ42 [i.e., PT-Sal (E) and Sal-only (F)] mice. No punctate immunofluorescence like FITC-Aβ 42 was seen in PT-Sal (E) and Sal-only (F) mice. PN, Pyramidal neurons: BV, blood vessel; Cap, capillary; PT, Pertussis toxin; Ctx, cerebral cortex. Scale bar = 50μm.

Article Snippet: Aβ peptides (FITC-Aβ 42 , Anaspec, San Jose, CA; unlabeled Aβ peptides, Biosource, Camarillo, CA) were solubilized to the monomeric form according to the method described by Zagorski et al. (1999) [ ].

Techniques: Labeling, Injection, Membrane, Fluorescence, Immunofluorescence

Cortical pyramidal neurons in mice treated with PT + unlabeled A β 42 (U-A β 42 ) peptide showed an increase in intraneuronal A β 42 accumulation comparable to that seen in mice treated with PT+FITC-labeled A β 42 (FITC-A β 42 ) peptide . Bright-field immunohistochemistry with anti-Aβ 42 primary antibody was used to compare the fates of injected U-Aβ 42 and FITC-Aβ 42 in the context of PT-induced chronic BBB breakdown. A, B) Both PT + U-Aβ 42 - and PT + FITC-Aβ 42 -treated mice demonstrated increased neuronal accumulation of Aβ 42 in the cerebral cortex (Ctx), red arrows. C) No evidence of neuronal Aβ 42 deposition was observed in Sal-only mice. D) Mice in the PT-Sal group also demonstrated some intraneuronal Aβ 42 , but this was much less extensive and was often largely confined to small, isolated groups of neurons. This suggests that soluble, endogenous mouse Aβ 42 is also able to enter the brain parenchyma through a defective BBB. It is important to point out that, using the bright field microscopy, we are unable to differentiate between endogenous Aβ 42 peptides from the FITC-Aβ 42 peptide. PN, pyramidal neuron; BV, blood vessel; Cap, capillary; PT, Pertussis toxin; Sal, saline. Scale bar = 50μm.

Journal: Journal of Alzheimer's Disease

Article Title: A Chronic Increase in Blood-Brain Barrier Permeability Facilitates Intraneuronal Deposition of Exogenous Bloodborne Amyloid-Beta 1–42 Peptide in the Brain and Leads to Alzheimer’s Disease-Relevant Cognitive Changes in a Mouse Model

doi: 10.3233/JAD-231028

Figure Lengend Snippet: Cortical pyramidal neurons in mice treated with PT + unlabeled A β 42 (U-A β 42 ) peptide showed an increase in intraneuronal A β 42 accumulation comparable to that seen in mice treated with PT+FITC-labeled A β 42 (FITC-A β 42 ) peptide . Bright-field immunohistochemistry with anti-Aβ 42 primary antibody was used to compare the fates of injected U-Aβ 42 and FITC-Aβ 42 in the context of PT-induced chronic BBB breakdown. A, B) Both PT + U-Aβ 42 - and PT + FITC-Aβ 42 -treated mice demonstrated increased neuronal accumulation of Aβ 42 in the cerebral cortex (Ctx), red arrows. C) No evidence of neuronal Aβ 42 deposition was observed in Sal-only mice. D) Mice in the PT-Sal group also demonstrated some intraneuronal Aβ 42 , but this was much less extensive and was often largely confined to small, isolated groups of neurons. This suggests that soluble, endogenous mouse Aβ 42 is also able to enter the brain parenchyma through a defective BBB. It is important to point out that, using the bright field microscopy, we are unable to differentiate between endogenous Aβ 42 peptides from the FITC-Aβ 42 peptide. PN, pyramidal neuron; BV, blood vessel; Cap, capillary; PT, Pertussis toxin; Sal, saline. Scale bar = 50μm.

Article Snippet: Aβ peptides (FITC-Aβ 42 , Anaspec, San Jose, CA; unlabeled Aβ peptides, Biosource, Camarillo, CA) were solubilized to the monomeric form according to the method described by Zagorski et al. (1999) [ ].

Techniques: Labeling, Immunohistochemistry, Injection, Isolation, Microscopy, Saline

The density of A β 42 positive neurons in the cerebral cortex was highest in PT-A β 42 mice. A) A comparison of the density of Aβ 42 -positive neurons in mice injected with FITC-Aβ 42 peptide was carried out by immunofluorescent microscopy. A difference in the density of Aβ 42 -positive neurons in the cerebral cortex was detected across the three treatment groups. Comparison of the density of Aβ 42 -positive neurons reached statistical significance (Mann-Whitney tests, p < 0.0001) between the Sal-only and PT-FITC-Aβ 42 groups. The difference in the density of Aβ 42 -positive neurons also reached statistical significance (Mann-Whitney tests, p < 0.0001) between the PT-Sal and PT-FITC-Aβ 42 groups. B) Comparison of the density of Aβ 42 -positive neurons reached statistical significance (Mann-Whitney tests, p < 0.0001) between the Sal-only and PT-Aβ 42 groups. Similarly, group comparisons between Sal and PT-Sal, and PT-Sal and PT-Aβ 42 groups also attained statistical significance (Mann-Whitney tests, p < 0.001 and p < 0.01, respectively). Error bars are standard error of the mean (SEM).

Journal: Journal of Alzheimer's Disease

Article Title: A Chronic Increase in Blood-Brain Barrier Permeability Facilitates Intraneuronal Deposition of Exogenous Bloodborne Amyloid-Beta 1–42 Peptide in the Brain and Leads to Alzheimer’s Disease-Relevant Cognitive Changes in a Mouse Model

doi: 10.3233/JAD-231028

Figure Lengend Snippet: The density of A β 42 positive neurons in the cerebral cortex was highest in PT-A β 42 mice. A) A comparison of the density of Aβ 42 -positive neurons in mice injected with FITC-Aβ 42 peptide was carried out by immunofluorescent microscopy. A difference in the density of Aβ 42 -positive neurons in the cerebral cortex was detected across the three treatment groups. Comparison of the density of Aβ 42 -positive neurons reached statistical significance (Mann-Whitney tests, p < 0.0001) between the Sal-only and PT-FITC-Aβ 42 groups. The difference in the density of Aβ 42 -positive neurons also reached statistical significance (Mann-Whitney tests, p < 0.0001) between the PT-Sal and PT-FITC-Aβ 42 groups. B) Comparison of the density of Aβ 42 -positive neurons reached statistical significance (Mann-Whitney tests, p < 0.0001) between the Sal-only and PT-Aβ 42 groups. Similarly, group comparisons between Sal and PT-Sal, and PT-Sal and PT-Aβ 42 groups also attained statistical significance (Mann-Whitney tests, p < 0.001 and p < 0.01, respectively). Error bars are standard error of the mean (SEM).

Article Snippet: Aβ peptides (FITC-Aβ 42 , Anaspec, San Jose, CA; unlabeled Aβ peptides, Biosource, Camarillo, CA) were solubilized to the monomeric form according to the method described by Zagorski et al. (1999) [ ].

Techniques: Comparison, Injection, Microscopy, MANN-WHITNEY

The hippocampal region of PT -A β 42 mice also showed increased BBB breakdown and intraneuronal accumulation of FITC-A β 42 . A–C) Representative images from paraffin-embedded sections through the hippocampal region of PT-Aβ 42 mice showing extensive BBB leak of IgG compared to PT-only and Sal-only groups. D) Representative images from PT-FITC-Aβ 42 -treated mice demonstrating intraneuronal accumulation of FITC-Aβ 42 in hippocampal hilar neurons. E, F) The hippocampal region of the PT-Sal and Sal-only mice lacked FITC-positive fluorescence. Hippo, hippocampus; BV, blood vessel; Cap, capillary. Scale bar = 50μm.

Journal: Journal of Alzheimer's Disease

Article Title: A Chronic Increase in Blood-Brain Barrier Permeability Facilitates Intraneuronal Deposition of Exogenous Bloodborne Amyloid-Beta 1–42 Peptide in the Brain and Leads to Alzheimer’s Disease-Relevant Cognitive Changes in a Mouse Model

doi: 10.3233/JAD-231028

Figure Lengend Snippet: The hippocampal region of PT -A β 42 mice also showed increased BBB breakdown and intraneuronal accumulation of FITC-A β 42 . A–C) Representative images from paraffin-embedded sections through the hippocampal region of PT-Aβ 42 mice showing extensive BBB leak of IgG compared to PT-only and Sal-only groups. D) Representative images from PT-FITC-Aβ 42 -treated mice demonstrating intraneuronal accumulation of FITC-Aβ 42 in hippocampal hilar neurons. E, F) The hippocampal region of the PT-Sal and Sal-only mice lacked FITC-positive fluorescence. Hippo, hippocampus; BV, blood vessel; Cap, capillary. Scale bar = 50μm.

Article Snippet: Aβ peptides (FITC-Aβ 42 , Anaspec, San Jose, CA; unlabeled Aβ peptides, Biosource, Camarillo, CA) were solubilized to the monomeric form according to the method described by Zagorski et al. (1999) [ ].

Techniques: Fluorescence