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Image Search Results
Journal: Cells
Article Title: Genetic Mouse Models to Study Pancreatic Cancer-Induced Pain and Reduction in Well-Being
doi: 10.3390/cells11172634
Figure Lengend Snippet: Neuronal remodeling is detectable across several fiber classes . ( A – H ): Quantification of the nerve fiber hypertrophy ( A ) and nerve fiber density ( B ) for Calcitonin Gene-Related Peptide (CGRP)-positive fibers (peptidergic nociceptive fibers), Tyrosine hydroxylase (TH)-positive fibers (sympathetic fibers and C-low threshold mechanoreceptors) and Neurofilament Protein 200 (NF200)-positive fibers (A beta fibers). The number of investigated mice is given in brackets. Representative images are shown in ( C – H ) (scale bar = 100 µm). Data are presented as mean ± S.E.M. * p < 0.05 in comparison between KPPC and control mice, Student’s t -test.
Article Snippet: We used the following primary antibodies: Anti-β-tubulin III (1:500, #T2200, Sigma Aldrich, St. Louis, MO, USA) and PGP 9.5 (1:500, #PA1-46204, ThermoFisher Scientifics, Waltham, MA, USA) as phenotypic marker for peripheral neurons, Anti-Calcitonin Gene Related Peptide (Anti-CGRP; 1:300; #24112; ImmunoStar, Herford, Germany) as marker for
Techniques: