Journal: Journal of cellular and molecular medicine

Article Title: Felodipine Promotes the Recovery of Mice With Spinal Cord Injury by Activating Macrolipophagy Through the AMPK-mTOR Pathway.

doi: 10.1111/jcmm.70543

Figure Lengend Snippet: FIGURE 4 | Felodipine promoted tissue repair and behavioural re- covery of the injured spinal cord. (A) The H&E and Nissl staining spinal cord sections following SCI. Scale bar: 100 μm. (B) Counting analysis of Nissl staining positive neurons. (C) The BMS score of mice at the cor- responding time points. **Represents p < 0.01 versus the sham group.

Article Snippet: Felodipine and Bodipy were bought from MCE (NJ, USA).

Techniques: Staining

Journal: Journal of cellular and molecular medicine

Article Title: Felodipine Promotes the Recovery of Mice With Spinal Cord Injury by Activating Macrolipophagy Through the AMPK-mTOR Pathway.

doi: 10.1111/jcmm.70543

Figure Lengend Snippet: FIGURE 5 | Felodipine could inhibit VEC fibrosis by activating autophagy in vivo. (A) Immunofluorescence staining of collagen I (green), CD31 (red) and DAPI (blue) in each group following SCI. Scale bar: 100 μm. (B) The Masson staining spinal cord sections following SCI. Scale bar: 100 μm. (C) Counting analysis collagen per aera by Masson staining. (D) Immunofluorescence staining of CD31 (red), LC3 (white) and DAPI (blue) in each group following SCI. Scale bar: 100 μm. (E and F) The mean fluorescence intensity of collagen I and CD31 in each group. (G and H) The mean fluo- rescence intensity of LC3 in each group. N.S. (not significant), **represents p < 0.01 versus the sham group and ##represents p < 0.01 versus the sham group. The data are the mean ± SD (n = 3).

Article Snippet: Felodipine and Bodipy were bought from MCE (NJ, USA).

Techniques: In Vivo, Immunofluorescence, Staining, Fluorescence

Journal: Journal of cellular and molecular medicine

Article Title: Felodipine Promotes the Recovery of Mice With Spinal Cord Injury by Activating Macrolipophagy Through the AMPK-mTOR Pathway.

doi: 10.1111/jcmm.70543

Figure Lengend Snippet: FIGURE 7 | Felodipine promoted the recovery of mice with SCI by activating macrolipophagy. Schematic diagram indicating how felodipine promoted SCI recovery.

Article Snippet: Felodipine and Bodipy were bought from MCE (NJ, USA).

Techniques:

Journal: International journal of pharmaceutics

Article Title: Amorphous solid dispersion of a binary formulation with felodipine and HPMC for 3D printed floating tablets.

doi: 10.1016/j.ijpharm.2024.124215

Figure Lengend Snippet: Fig. 1. Snapshot of a molecular dynamics (MD) simulation (after the cycle at 298 K, 15 ns) with felodipine and HPMC as tube model, where for the latter polymer, a semi-transparent molecular surface area is shown.

Article Snippet: Felodipine (Carbosynth Ltd., Compton, Berkshire, UK) was used as the model drug.

Techniques: Polymer

Journal: International journal of pharmaceutics

Article Title: Amorphous solid dispersion of a binary formulation with felodipine and HPMC for 3D printed floating tablets.

doi: 10.1016/j.ijpharm.2024.124215

Figure Lengend Snippet: Fig. 2. Images of the drug-loaded filaments containing 15% of felodipine (a) AFM topographical, (b) 3D-overlaid height/phase, and (c) confocal LSM; images of powder felodipine (d) AFM topographical, (e) 3D-overlaid height/phase, and f) LSM.

Article Snippet: Felodipine (Carbosynth Ltd., Compton, Berkshire, UK) was used as the model drug.

Techniques:

Journal: International journal of pharmaceutics

Article Title: Amorphous solid dispersion of a binary formulation with felodipine and HPMC for 3D printed floating tablets.

doi: 10.1016/j.ijpharm.2024.124215

Figure Lengend Snippet: Fig. 6. Drug-loaded filaments surface from 5%, 10% and 15% of felodipine (a, b, c, respectively). Solid top layer of the 3DP tablets made with the filaments of 5%, 10% and 15% of felodipine (d, e, f, respectively). Internal mesh of the 3DP tablets made with the filaments of 5%, 10% and 15% of felodipine (g, h, i, respectively).

Article Snippet: Felodipine (Carbosynth Ltd., Compton, Berkshire, UK) was used as the model drug.

Techniques:

Journal: Nanoscale Research Letters

Article Title: Size- and time-dependent alteration in metabolic activities of human hepatic cytochrome P450 isozymes by gold nanoparticles via microsomal coincubations

doi: 10.1186/1556-276X-9-642

Figure Lengend Snippet: Summary of accuracy and precision of the analytical method for the six probe CYP metabolites

Article Snippet: Hydroxy tolbutamide, ( S )-mephenytoin, and dehydro felodipine were provided by Toronto Research Chemicals (North York, Canada).

Techniques: Concentration Assay

Journal: Nanoscale Research Letters

Article Title: Size- and time-dependent alteration in metabolic activities of human hepatic cytochrome P450 isozymes by gold nanoparticles via microsomal coincubations

doi: 10.1186/1556-276X-9-642

Figure Lengend Snippet: Dose- and size-dependent nonspecific binding of AuNPs with CYP marker metabolites. Six probe metabolites with standard solutions (low, medium, and high concentrations) were coincubated separately with 5, 7, 30, 70 nm AuNPs in PBS to a final volume of 200 μL at 37°C, in the absence or presence of 0.15 mg mL -1 HLM, and terminated the incubation after 30 min by adding 200 μL of acetonitrile containing IS. CYP3A4 (a) represents testosterone 6 β -hydroxylase, and CYP3A4 (b) represents felodipine dehydrogenase. Data are mean values ± SD ( n = 3) and are expressed as a percentage of QC samples of the metabolites incubated without AuNPs.

Article Snippet: Hydroxy tolbutamide, ( S )-mephenytoin, and dehydro felodipine were provided by Toronto Research Chemicals (North York, Canada).

Techniques: Binding Assay, Marker, Incubation

Journal: International Journal of Pharmaceutics

Article Title: Physical stability of drugs after storage above and below the glass transition temperature: Relationship to glass-forming ability

doi: 10.1016/j.ijpharm.2015.08.101

Figure Lengend Snippet: Compounds used in the study with their molecular weight (MW), melting temperature ( T m ), heat of fusion (ΔH), glass transition temperature ( T g ), temperature for the stability test above T g ( T above = T g + 20), change in free energy (ΔG) between the supercooled liquid and the crystalline state at T, and result of the stability test (no = crystalline and yes = amorphous). Pi_AQc = sum of absolute values of Hückel pi atomic charges on C atoms; F_AromB = number of aromatic bonds as a fraction of total bonds; TR = training set; TS = test set.

Article Snippet: All chemicals were of high purity (98.0–99.9%) and purchased from Sigma–Aldrich (Stockholm, Sweden) except for danazol (Coral drugs IVT, India), itraconazole (Lee Pharma Ltd., India) ezetimibe and ketoconazole (TCR, Toronto, Canada) and bicalutamide, felodipine and linaprazan which were received as a kind gift from AstraZeneca (Mölndal, Sweden), The compounds were selected to provide a wide range of T g s (225–425 K; ) and all were previously identified as compounds with GFA ( ).

Techniques: Molecular Weight