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Image Search Results
Journal: mAbs
Article Title: RUBY® – a tetravalent (2+2) bispecific antibody format with excellent functionality and IgG-like stability, pharmacology and developability properties
doi: 10.1080/19420862.2024.2330113
Figure Lengend Snippet: Kinetic measurements for RUBY bsAbs of different Fc isotype variants and monoclonal isotype controls after binding to mFcγri, mFcγriib, mFcγriii and mFcγr IV.
Article Snippet: RUBY bsAb and monoclonal isotype controls were diluted to 200 nM in 1× Kinetic buffer and captured on 8 parallel sensors for 300 sec. After setting a new baseline, the captured antibodies were assayed against any of the FcγR (hFcγRI (1257-FC-050, R&D Systems), hFcγRIIa (1330-CD-050, R&D Systems), hFcγRIIb (1875-CD-050, R&D Systems), hFcγRIIIa (4325-FC-050, R&D Systems), hFcγRIIIa V176F (8894-FC-050, R&D Systems),
Techniques: Binding Assay