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MedChemExpress
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Tocris
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Tocris
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Santa Cruz Biotechnology
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Merck KGaA
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Inhibitor of glucose uptake via GLUT1 and GLUT4 transporters, promoting intracellular glucose deprivation. The compound is a chemical sensitizer to the FAS cell death receptor and is able to break down the resistance of caspase
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Fasentin is a GLUT1 and GLUT4 inhibitor (IC50 = 68 μM). Fasentin sensitizes Fas receptor in a range of tumor cell lines (IC50 = 20 μM) via regulating the extrinsic apoptotic pathway downstream of TNF
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Fasentin is a potent glucose uptake inhibitor. It inhibits GLUT-1/GLUT-4 transporters.
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Image Search Results
Journal: ACS chemical biology
Article Title: Discrimination of GLUTs by Fructose Isomers Enables Simultaneous Screening of GLUT5 and GLUT2 Activity in Live Cells
doi: 10.1021/acschembio.2c00682
Figure Lengend Snippet: Changes for P1–P3 uptake in MCF7 cells in the presence of inhibitors: MSNBA, CytB, GluAm, G2iA, and fasentin. Cell fluorescence was recorded using confocal microscopy. Fluorescence images (Figure S11) for every condition (DAPI, 60× objective, same laser intensity and exposure time) were quantified using ImageJ. Graphical data represents an average fluorescence of 7–20 cells from two repeats. Relative fluorescence for every probe in every condition was derived by normalizing the derived CTCF/area value for probe + inhibitor combination by the CTCF/area of the corresponding control (P1, P2, or P3). Error bars represent relative standard deviation between two independent experiments. A two-tailed t-test was used to detect statistically significant differences: *p ~ 0.01–0.001, **p ~ 0.001–0.0001.
Article Snippet: Cytochalasin B (CytB), MSNBA, glucosamine (GluAm), and
Techniques: Fluorescence, Confocal Microscopy, Derivative Assay, Control, Standard Deviation, Two Tailed Test