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Image Search Results
Journal: PLoS ONE
Article Title: Autophagy Induced by HIF1α Overexpression Supports Trophoblast Invasion by Supplying Cellular Energy
doi: 10.1371/journal.pone.0076605
Figure Lengend Snippet: (a) In an intact invasion of EVTs, HIF1α activates autophagy via the PI3K pathway. Autophagy then supplies cellular energy to enhance the invasion of EVTs. (b) In an invasion failure, severe hypoxia or long term hypoxia may accelerate HIF1α overexpression in EVTs. EVTs with an impaired autophagy status by soluble endoglin did not produce energy for the invasion of EVTs with HIF1α overexpression, resulting in the inhibition of EVT invasion. Compensatory P2RX7 expression was enhanced by reacting to the decrease in cellular energy in EVTs observed with preeclampsia.
Article Snippet: We previously reported that autophagy in
Techniques: Over Expression, Inhibition, Expressing