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Image Search Results
Journal: Blood Advances
Article Title: Polyphosphate-induced thrombosis in mice is factor XII dependent and is attenuated by histidine-rich glycoprotein
doi: 10.1182/bloodadvances.2021004567
Figure Lengend Snippet: Comparison of the effect of IP polyP on perfusion and fibrin deposition in the lungs of wild-type (WT) or HRG-deficient mice. (A) Evans blue dye was injected into the right ventricle of WT or HRG−/− mice administered IP saline or polyP. Images of the lungs were taken to examine the extent of dye perfusion into the lungs. Representative images from 6 mice per group are shown. (B) Evans blue dye extracted from lungs with formamide was quantified by measuring absorbance at 605 nm and calculating the amount of dye per microgram of tissue by comparison with a standard curve. N = 6 mice per group; bars represent mean ± standard deviation. (C) Fibrin deposition (red) in lung sections was detected by immunofluorescence with 4′,6-diamidino-2-phenylindole (blue) serving as a nuclear stain. Scale bars represent 50 μm. Representative images from six mice per treatment group are shown. (D) Fibrin intensity was scored in a blinded manner by using a scale of 0 to 4, with 4 representing the greatest intensity. N = 6 mice per group; bars represent mean ± standard deviation. *P < .05, **P < .01, ***P < .001 comparison between saline- or polyP-treated WT or HRG−/− mice as indicated by the lines (analysis of variance, Holm-Šídák method).
Article Snippet: Briefly, 200 μL of 1% sterile-filtered
Techniques: Injection, Standard Deviation, Immunofluorescence, Staining
Journal: Food Science & Nutrition
Article Title: Hydroxysafflor yellow A, a natural food pigment, ameliorates atherosclerosis in ApoE −/− mice by inhibiting the SphK1 / S1P / S1PR3 pathway
doi: 10.1002/fsn3.4466
Figure Lengend Snippet: Hydroxysafflor yellow A (HSYA) enhanced vascular plaque stability and alleviated aortic endothelial permeability in ApoE −/− mice. (a, b) Representative immunohistochemical images and quantification of VCAM‐1 expression in the aortic root. Scale bar: 200 μm. (c, d) Representative images of TUNEL staining and quantitative analysis. Scale bar: 200 μm. (e, f) Evans blue staining of the mid‐aorta and determination of Evans blue content. Scale bar: 200 μm. Data were presented as the mean ± SEM ( n = 3). ### p < .001 versus Ctrl group; *** p < .001 versus Model group.
Article Snippet: One hour before execution, mice were injected with 0.5% 2 mL/kg
Techniques: Permeability, Immunohistochemical staining, Expressing, TUNEL Assay, Staining