Journal: The Journal of Neuroscience

Article Title: Mild Cognitive Impairment Is Characterized by Deficient Brainstem and Cortical Representations of Speech

doi: 10.1523/JNEUROSCI.3700-16.2017

Figure Lengend Snippet: Neuroelectric brain activity reveals deficient speech coding at subcortical and cortical levels in MCI. a, b, Brainstem FFR time waveforms (a) and spectra (b) illustrating responses to the two prototypical vowel tokens /u/ (vw1) and /a/ (vw5). Time waveforms show phase-locked neural activity from the brainstem. ▾ indicates the onset of the time-locking speech stimulus. MCI FFRs are characterized by an increase in amplitude that is largely attributed to hypersensitive coding of the vowel's fundamental frequency (H1 = 100 Hz) and integer-related harmonics (H2–H6). c, Cortical ERPs to speech. As with brainstem FFRs, MCI shows aberrant neural speech coding at the cortical level as indicated by overexaggerated N1–P2 magnitudes.

Article Snippet: Predictive power of subcortical versus cortical ERPs in predicting MCI severity Previous studies showed normal or slightly larger responses of the early cortical ERPs (e.g., P1) in patients with mild-to-moderate Alzheimer's disease relative to age-matched controls ( Golob and Starr, 2000 ).

Techniques: Activity Assay

Journal: The Journal of Neuroscience

Article Title: Mild Cognitive Impairment Is Characterized by Deficient Brainstem and Cortical Representations of Speech

doi: 10.1523/JNEUROSCI.3700-16.2017

Figure Lengend Snippet: Brainstem FFR and cortical ERP results with the control group split by median age (control analysis). Otherwise, as in Figure 4, c and d. In contrast to the substantial MCI versus control differences observed in FFRs, both brainstem (a) and cortical (b) responses were indistinguishable when comparing the oldest and youngest of the cognitively normal listeners. Absent effects in both brainstem and cortical ERPs confirms that the MCI-related changes that we find in speech processing are not due to aging alone.

Article Snippet: Predictive power of subcortical versus cortical ERPs in predicting MCI severity Previous studies showed normal or slightly larger responses of the early cortical ERPs (e.g., P1) in patients with mild-to-moderate Alzheimer's disease relative to age-matched controls ( Golob and Starr, 2000 ).

Techniques: Control

Journal: International journal of language & communication disorders / Royal College of Speech & Language Therapists

Article Title: ERPs reveal atypical processing of subject versus object Wh -questions in children with specific language impairment

doi: 10.1111/1460-6984.12009

Figure Lengend Snippet: Grand average multiword ERPs for subject and object questions in the left anterior (Electrical Geodesics Inc. (EGI) 12, 13, 9, 16) and right anterior (EGI 2, 62, 57, 58) regions in TD (n = 17) and SLI (n = 13) children.

Article Snippet: Open in a separate window Figure 1 Grand average multiword ERPs for subject and object questions in the left anterior (Electrical Geodesics Inc. (EGI) 12, 13, 9, 16) and right anterior (EGI 2, 62, 57, 58) regions in TD (n = 17) and SLI (n = 13) children.

Techniques:

Journal: International journal of language & communication disorders / Royal College of Speech & Language Therapists

Article Title: ERPs reveal atypical processing of subject versus object Wh -questions in children with specific language impairment

doi: 10.1111/1460-6984.12009

Figure Lengend Snippet: Grand average multiword ERPs for subject and object questions in the left anterior (Electrical Geodesics Inc. (EGI) 11 & 12) and right anterior (EGI 6 & 2) regions in ADULTS (n = 14).

Article Snippet: Open in a separate window Figure 1 Grand average multiword ERPs for subject and object questions in the left anterior (Electrical Geodesics Inc. (EGI) 12, 13, 9, 16) and right anterior (EGI 2, 62, 57, 58) regions in TD (n = 17) and SLI (n = 13) children.

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Journal: Brain research

Article Title: Multisensory integration in children: A preliminary ERP study

doi: 10.1016/j.brainres.2008.03.090

Figure Lengend Snippet: Event Related Potentials (ERPs). The grand averages of event related potentials (ERPs) for auditory (black traces), somatosensory (red traces) and simultaneous auditory and somatosensory stimuli (green traces) are shown for a sample of 21 children. The ERPs are shown at midline electrode sites (Fz, Cz and Pz) and central/post-central electrode sites (C3, CP5, C4 and CP6). The P100, N100 and P200 ERP amplitude peaks are labeled at electrode site Cz. The placement of the electrode sites are indicated in a top view schematic in the upper left corner.

Article Snippet: Moreover, mid-latency somatosensory ERPs show a substantial increase in the latency and amplitude of ERP components with age ( Zumsteg and Wieser, 2002 ).

Techniques: Labeling

Journal: Brain research

Article Title: Multisensory integration in children: A preliminary ERP study

doi: 10.1016/j.brainres.2008.03.090

Figure Lengend Snippet: ERP voltage maps. The spatio-temporal distribution of grand average auditory and somatosensory ERPs are displayed in 20 ms intervals. The key to the right shows the range of voltages (in µV) for both types of ERPs.

Article Snippet: Moreover, mid-latency somatosensory ERPs show a substantial increase in the latency and amplitude of ERP components with age ( Zumsteg and Wieser, 2002 ).

Techniques:

Journal: Brain research

Article Title: Multisensory integration in children: A preliminary ERP study

doi: 10.1016/j.brainres.2008.03.090

Figure Lengend Snippet: Auditory–somatosensory multisensory integration (MSI). The grand averages of ERPs for 21 children are shown for the seven electrode sites (Fz, Cz Pz, C3, CP5, C4 and CP6) designated in the schematic in the upper left-hand corner. Simultaneous auditory and somatosensory ERPs (green traces) are compared to the sum of unisensory auditory added to unisensory somatosensory ERPs (orange traces). Difference waves (black traces = simultaneous – summed) identify possible scalp locations for MSI.

Article Snippet: Moreover, mid-latency somatosensory ERPs show a substantial increase in the latency and amplitude of ERP components with age ( Zumsteg and Wieser, 2002 ).

Techniques:

Journal: Brain research

Article Title: Multisensory integration in children: A preliminary ERP study

doi: 10.1016/j.brainres.2008.03.090

Figure Lengend Snippet: P-values for MSI. Significant p values are displayed over time for 32 electrodes from running t-tests comparing the simultaneous (AS) and summed (A+S) ERPs. Statistically significant p values ranging from 0.01 to 0.05 are represented by the color code (key is to the right of graph). Time is plotted on the x-axis from 0 to 400 ms. Electrode sites are plotted on the y-axis.

Article Snippet: Moreover, mid-latency somatosensory ERPs show a substantial increase in the latency and amplitude of ERP components with age ( Zumsteg and Wieser, 2002 ).

Techniques: