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Image Search Results
Journal: Clinical Neuropathology
Article Title: Clinical Neuropathology practice news 1-2014: Pyrosequencing meets clinical and analytical performance criteria for routine testing of MGMT promoter methylation status in glioblastoma
doi: 10.5414/NP300730
Figure Lengend Snippet: Summary of the results of MGMT promoter methylation testing in cases with unmethylated MGMT promoter according to the reference laboratory. There is a perfect concordance) of MGMT status in all samples irrespective of tissue fixation conditions, testing laboratory, testing technician and time point of testing. Cut-offs for defining MGMT promoter methylated vs. unmethylated cases: for MSRE: 0.32%, for PSQ: 8%. PSQ-% represent the mean-methylation values from four CpG analyzed and calculated from pyrograms.
Article Snippet: Case 8 ,
Techniques: Methylation
Journal: Clinical Neuropathology
Article Title: Clinical Neuropathology practice news 1-2014: Pyrosequencing meets clinical and analytical performance criteria for routine testing of MGMT promoter methylation status in glioblastoma
doi: 10.5414/NP300730
Figure Lengend Snippet: Summary of the results of MGMT promoter methylation testing in cases with methylated MGMT promoter according to the reference laboratory. There is a perfect correlation (100% concordance) of MGMT status in all samples irrespective of tissue fixation conditions, testing laboratory, testing technician and time point of testing. Cut-offs and abbreviations: same as Table 1.
Article Snippet: Case 8 ,
Techniques: Methylation
Journal: Biomolecules
Article Title: An Epigenomic Approach to Improving Response to Neoadjuvant Cisplatin Chemotherapy in Bladder Cancer
doi: 10.3390/biom6030037
Figure Lengend Snippet: HOXA9 promoter methylation as marker for sensitivity and resistance in bladder cancer cell lines. ( A ) Expression profiling and hierarchical clustering of top sensitive and top resistant bladder cancer cell lines identifies candidate genes to explain sensitivity and resistance to chemotherapy. The LIMMA package (version 3.28.20) was used for analyzing differential expression of RNA sequencing (RNAseq) data between sensitive and resistant cell lines; ( B ) The HOXA9 promoter is methylated in resistant cell lines ( p < 0.001). Methylation quantification of the HOX9A promoter was carried out using the EpiTYPER assay.
Article Snippet:
Techniques: Methylation, Marker, Expressing, Quantitative Proteomics, RNA Sequencing, EpiTYPER Assay
Journal: Biomolecules
Article Title: An Epigenomic Approach to Improving Response to Neoadjuvant Cisplatin Chemotherapy in Bladder Cancer
doi: 10.3390/biom6030037
Figure Lengend Snippet: HOXA9 promoter methylation is associated with chemoresistance of human muscle-invasive bladder cancer tissue. ( A ) CpG methylation at the HOXA9 promoter is increased in resistant compared to sensitive tumor samples. Methylation quantification of tumor samples was carried out using the EpiTYPER assay; ( B ) Based on methylation levels detected in the cisplatin sensitive cell lines, a cut-off methylation level of 12% was defined as predictive of cisplatin resistance. Resistant tumor samples ( n = 9) show methylation levels >12% ( p < 0.001).
Article Snippet:
Techniques: Methylation, CpG Methylation Assay, EpiTYPER Assay