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GL Biochem
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Image Search Results
Journal: Nature Communications
Article Title: A modular biomimetic strategy for the synthesis of macrolide P-glycoprotein inhibitors via Rh-catalyzed C-H activation
doi: 10.1038/s41467-020-16084-0
Figure Lengend Snippet: a Reaction conditions: i) NH 2 -A-A-COOMe (1.5 equiv.), EDCI (1.2 equiv.), HOBt (1.5 equiv.), Et 3 N (4.5 equiv.), DMF, r.t., overnight or NH 2 -A-A-COOMe (1.5 equiv.), HATU (1.5 equiv.), DIPEA (4.0 equiv.), DMF, r.t., overnight; ii) LiOH (10.0 equiv.), MeOH/H 2 O (1:1), r.t., 1 h; iii) EDCI (3.0 equiv.), HOBt (3.0 equiv.), DMF/DCM (1:4), r.t., overnight. b The picture is 500 mg of 4g synthesized by this method.
Article Snippet: Fig. 6 Construction of functional ( Z )-allylic-supported macrolides by a
Techniques: Synthesized