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Image Search Results
Journal: American Journal of Physiology - Gastrointestinal and Liver Physiology
Article Title: Molecular characterization of a precision-cut rat liver slice model for the evaluation of antifibrotic compounds
doi: 10.1152/ajpgi.00281.2018
Figure Lengend Snippet: ELISA analysis of secreted biomarkers. SB525334, nintedanib, and sorafenib suppressed secretion of hyaluronic acid (HA), insulin-like growth factor binding protein 5 (IGFBP5), and WNT1-inducible signaling pathway protein 1 (WISP1) in the conditioned medium after 48 h of incubation. Data are means ± SE; n = 3 rats for both sham and bile duct ligation (BDL); n = 8–10 liver slices for each condition. **P < 0.01 and ***P < 0.001.
Article Snippet: Secreted biomarkers including procollagen I, HA,
Techniques: Enzyme-linked Immunosorbent Assay, Binding Assay, Incubation, Ligation
Journal: American Journal of Physiology - Gastrointestinal and Liver Physiology
Article Title: Molecular characterization of a precision-cut rat liver slice model for the evaluation of antifibrotic compounds
doi: 10.1152/ajpgi.00281.2018
Figure Lengend Snippet: The small molecule αV integrins inhibitor CWHM12 attenuated fibrotic phenotype in fibrotic precision-cut liver tissue slices (PCLSs) after 48 h of incubation. A: CWHM12 suppressed expression of a panel of fibrotic genes. B: CWHM12 decreased secretion of procollagen I, hyaluronic acid (HA), insulin-like growth factor binding protein 5 (IGFBP5), and WNT1-inducible signaling pathway protein 1 (WISP1) in the conditioned medium. Data are means ± SE; n = 3 rats for both sham and bile duct ligation (BDL); n = 6–8 liver slices for each condition. *P < 0.05, **P < 0.01, ***P < 0.001.
Article Snippet: Secreted biomarkers including procollagen I, HA,
Techniques: Incubation, Expressing, Binding Assay, Ligation
Journal: Acta tropica
Article Title: Echinococcus granulosus promotes bone resorption by increasing osteoclasts differentiation.
doi: 10.1016/j.actatropica.2023.107027
Figure Lengend Snippet: Fig. 1. PSCs promote osteoclast differentiation. (A and B) BMMs were grouped to induce differentiation under different interventions and osteoclast formation was detected by TRAP staining. (C and D) Actin ring formation in response to different stimuli. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001 vs the M-CSF + RANKL group. Data are presented as the mean ± SD of three independent experiments. The scale bar is 500 μm.
Article Snippet: Recombinant mouse M-CSF (#416-ML/CF) and
Techniques: Staining
Journal: Acta tropica
Article Title: Echinococcus granulosus promotes bone resorption by increasing osteoclasts differentiation.
doi: 10.1016/j.actatropica.2023.107027
Figure Lengend Snippet: Fig. 2. PSCs promote the expression of osteoclast-related proteins and genes. (A) BMMs were cultured for 24 h using the same intervention method, total RNA was extracted, and the target gene was detected. (B and C) The expression of target proteins was detected between the groups. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001 vs the M-CSF + RANKL group. #P < 0.05, ##P < 0.01, ###P < 0.001, ####P < 0.0001 vs the M-CSF group. Data are presented as the mean ± SD of three independent experiments.
Article Snippet: Recombinant mouse M-CSF (#416-ML/CF) and
Techniques: Expressing, Cell Culture