Journal: Heliyon

Article Title: CD56 bri CD38 + as a novel neutrophil-specific marker in chronic myeloid leukemia

doi: 10.1016/j.heliyon.2024.e39465

Figure Lengend Snippet: Clinical characteristics of patients in learning and validation cohorts.

Article Snippet: The BCR/ABL1 fusion quantitative detection kit (Shanghai Yuanqi Biomedical Technology Co., Ltd.) was utilized for the assessment of BCR-ABL1 transcripts [ ].

Techniques:

Journal: Heliyon

Article Title: CD56 bri CD38 + as a novel neutrophil-specific marker in chronic myeloid leukemia

doi: 10.1016/j.heliyon.2024.e39465

Figure Lengend Snippet: The percentage of CD56 bri CD38 + neutrophils was independent of neutrophil count, risk stratification and BCR/ABL1 fusion gene but correlated with blast cells immunophenotype. A. Correlation of the percentage of CD56 bri CD38 + neutrophils with percentage of CD56 + form CD34 + cells. B. Correlation of the percentage of CD56 bri CD38 + neutrophils with neutrophil count. C. Correlation of the percentage of CD56 bri CD38 + neutrophils determined by flow cytometry with the BCR/ABL1 (IS, %). D. Correlation of the percentage of CD56 bri CD38 + neutrophils determined by flow cytometry with different risk groups (grouped according to Sokal score).

Article Snippet: The BCR/ABL1 fusion quantitative detection kit (Shanghai Yuanqi Biomedical Technology Co., Ltd.) was utilized for the assessment of BCR-ABL1 transcripts [ ].

Techniques: Flow Cytometry

Journal: Heliyon

Article Title: CD56 bri CD38 + as a novel neutrophil-specific marker in chronic myeloid leukemia

doi: 10.1016/j.heliyon.2024.e39465

Figure Lengend Snippet: The changes in percentage of CD56 bri CD38 + neutrophils after treatment. A. Patients (n = 7) with BCR/ABL1 fusion gene (IS, %) achieved satisfactory curative effect after tyrosine kinase inhibitor (TKI) treatment. B. CD56 bri CD38+ neutrophils dropped below the cut-off (2.0 %) value in patients from (A) after treatment. C. The CD56 bri CD38 + neutrophils did not decrease in patients who did not achieve satisfactory curative effect after treatment. D. The CD56 bri CD38 + neutrophils decreased below the cut-off value in patients who did not achieve satisfactory curative effect after treatment. E. BCR/ABL1 fusion gene and CD56 bri CD38 + neutrophils change over time in patients under the blast phase of CML.

Article Snippet: The BCR/ABL1 fusion quantitative detection kit (Shanghai Yuanqi Biomedical Technology Co., Ltd.) was utilized for the assessment of BCR-ABL1 transcripts [ ].

Techniques:

Journal: Journal of Clinical Laboratory Analysis

Article Title: Association between squamous cell carcinoma antigen level and EGFR mutation status in Chinese lung adenocarcinoma patients

doi: 10.1002/jcla.24613

Figure Lengend Snippet: Multivariable regression for the association between SCCAg and EGFR mutation probability

Article Snippet: The EGFR gene mutation detection kit from Shanghai Yuanqi company was used with PCR fluorescent probe method to detect the mutations on EGFR gene Exon18 (G719C, G719S), Exon19 (2235–2249del, 2236–2250del, 2236–2253del, 2239–2253del, 2239–2256del, 2240–2251del, 2240–2254del, 2240–2257del, 2237–2255 > T, 2238–2248 > GC, 2237–2252 > GCA, 2239–2251 > C, 2254–2277del, 2238‐2255del, 2240–2248del, 2239–2259del), Exon20 (V769_D770insASV, D770_N771insG, H773_V774insH), and Exon21 (L858R, L861Q).

Techniques: Mutagenesis

Journal: Journal of Clinical Laboratory Analysis

Article Title: Association between squamous cell carcinoma antigen level and EGFR mutation status in Chinese lung adenocarcinoma patients

doi: 10.1002/jcla.24613

Figure Lengend Snippet: (A) Use the generalized additive model to fit a smooth curve to the relationship between SCCAg and EGFR mutation probability (the horizontal axis is the level of SCCAg, and the vertical axis is the adjusted EGFR mutation probability; solid red line represents the fitted line between EGFR mutation probability and SCCAg; blue dotted line is 95% confidence interval; the relationship was adjusted for age, sex, smoking history, nodule type, bronchial sign, pleural indentation sign, vessel convergence sign, tumor short diameter, and clinical stage). (B) Use the generalized additive model to fit a smooth curve to the relationship between SCCAg tertile and EGFR mutation probability (the horizontal axis is SCCAg tertile, and the vertical axis is the adjusted EGFR mutation probability; black dashed line represents the fitted line between EGFR mutation probability and SCCAg tertile; the red line is the 95% confidence interval; the relationship was adjusted for age, sex, smoking history, nodule type, bronchial sign, pleural indentation sign, vessel convergence sign, tumor short diameter, and clinical stage). EGFR , epidermal growth factor receptor; SCCAg, squamous cell carcinoma antigen.

Article Snippet: The EGFR gene mutation detection kit from Shanghai Yuanqi company was used with PCR fluorescent probe method to detect the mutations on EGFR gene Exon18 (G719C, G719S), Exon19 (2235–2249del, 2236–2250del, 2236–2253del, 2239–2253del, 2239–2256del, 2240–2251del, 2240–2254del, 2240–2257del, 2237–2255 > T, 2238–2248 > GC, 2237–2252 > GCA, 2239–2251 > C, 2254–2277del, 2238‐2255del, 2240–2248del, 2239–2259del), Exon20 (V769_D770insASV, D770_N771insG, H773_V774insH), and Exon21 (L858R, L861Q).

Techniques: Mutagenesis

Journal: Journal of Clinical Laboratory Analysis

Article Title: Association between squamous cell carcinoma antigen level and EGFR mutation status in Chinese lung adenocarcinoma patients

doi: 10.1002/jcla.24613

Figure Lengend Snippet: The stratification analysis of the association between SCCAg and the probability of EGFR mutation (OR, 95% CI, p ‐value, and p for interaction were calculated; adjusted for age, sex, smoking history, nodule type, bronchial sign, pleural indentation sign, vessel convergence sign, tumor short diameter, clinical stage). EGFR , epidermal growth factor receptor; CEA, carcinoembryonic antigen; CYFRA21‐1, cytokeratin soluble fragment 19; NSE, neuron‐specific enolase; *15 cases missing; #6 cases missing

Article Snippet: The EGFR gene mutation detection kit from Shanghai Yuanqi company was used with PCR fluorescent probe method to detect the mutations on EGFR gene Exon18 (G719C, G719S), Exon19 (2235–2249del, 2236–2250del, 2236–2253del, 2239–2253del, 2239–2256del, 2240–2251del, 2240–2254del, 2240–2257del, 2237–2255 > T, 2238–2248 > GC, 2237–2252 > GCA, 2239–2251 > C, 2254–2277del, 2238‐2255del, 2240–2248del, 2239–2259del), Exon20 (V769_D770insASV, D770_N771insG, H773_V774insH), and Exon21 (L858R, L861Q).

Techniques: Mutagenesis

Journal: Expert Reviews in Molecular Medicine

Article Title: Methylation multiplicity and its clinical values in cancer

doi: 10.1017/erm.2021.4

Figure Lengend Snippet: Clinical advances in using methylation as diagnostic markers for cancer early detection

Article Snippet: Lung-MeTM , SHOX2, RASSF1A , Lung cancer , qMSP , Bronchoalveolar lavage fluid , Tellgen , NMPA approved , China.

Techniques: Methylation, Diagnostic Assay, DNA Methylation Assay, Mutagenesis