Journal: Scientific Reports

Article Title: No modulation of pupil size and event-related pupil response by transcutaneous auricular vagus nerve stimulation (taVNS)

doi: 10.1038/s41598-019-47961-4

Figure Lengend Snippet: ( A ) Pupil diameter during the baseline measurement (left), change to baseline during the first five minutes of stimulation, and in the post-task resting measurement (~13 min after stimulation offset). ( B ) Left: Grand average pupillary response to stimulation onset and t-values. Dashed lines indicate t = ±2.04, i.e., the (uncorrected) two-tailed threshold for statistical significance at α = 0.05 and df = 32 (33 participants minus one). Right: relationship between mean pupil size in the 2 s before stimulation onset and mean change in pupil size in the first 10 s after stimulation onset. Negative correlations can be seen, consistent with previous studies.

Article Snippet: Stimulation current was delivered as monophasic square pulses at a pulse width of 200 μs, pulse frequency of 25 Hz and current intensity of 3.0 mA using a medical stimulation device (Digitimer DS7, www.digitimer.com ) triggered via a BNC cable by custom code running on an Arduino Uno circuit board ( www.arduino.cc ).

Techniques: Two Tailed Test

Journal: Scientific Reports

Article Title: No modulation of pupil size and event-related pupil response by transcutaneous auricular vagus nerve stimulation (taVNS)

doi: 10.1038/s41598-019-47961-4

Figure Lengend Snippet: ( A ) Upper panels: Pupillary response to standard and target stimuli in the auditory oddball task before (left), during (middle), and after stimulation (right). Lower panels: t-values comparing sham and taVNS. Dashed lines indicate t = ±2.04, i.e., the (uncorrected) two-tailed threshold for statistical significance at α = 0.05 and df = 32 (Thirty-three participants minus one). ( B ) Mean ± standard error of RT to target stimuli (error bars) and omission error rate (dots). ( C ) Tonic pupil size in the three task runs. ( D ) Temporal variability of tonic pupil size in standard trials, expressed as coefficient of variation (see Methods).

Article Snippet: Stimulation current was delivered as monophasic square pulses at a pulse width of 200 μs, pulse frequency of 25 Hz and current intensity of 3.0 mA using a medical stimulation device (Digitimer DS7, www.digitimer.com ) triggered via a BNC cable by custom code running on an Arduino Uno circuit board ( www.arduino.cc ).

Techniques: Two Tailed Test

Journal: Scientific Reports

Article Title: No modulation of pupil size and event-related pupil response by transcutaneous auricular vagus nerve stimulation (taVNS)

doi: 10.1038/s41598-019-47961-4

Figure Lengend Snippet: ( A ) Evolution of tonic pupil size over time-on-task during the on-stimulation run of the auditory oddball task, relative to session baseline. ( B ) Time-averaged pupillary responses to target stimuli over time-on-task, relative to pre-stimulus baseline.

Article Snippet: Stimulation current was delivered as monophasic square pulses at a pulse width of 200 μs, pulse frequency of 25 Hz and current intensity of 3.0 mA using a medical stimulation device (Digitimer DS7, www.digitimer.com ) triggered via a BNC cable by custom code running on an Arduino Uno circuit board ( www.arduino.cc ).

Techniques:

Journal: Scientific Reports

Article Title: No modulation of pupil size and event-related pupil response by transcutaneous auricular vagus nerve stimulation (taVNS)

doi: 10.1038/s41598-019-47961-4

Figure Lengend Snippet: Stimulation setup and current waveform.

Article Snippet: Stimulation current was delivered as monophasic square pulses at a pulse width of 200 μs, pulse frequency of 25 Hz and current intensity of 3.0 mA using a medical stimulation device (Digitimer DS7, www.digitimer.com ) triggered via a BNC cable by custom code running on an Arduino Uno circuit board ( www.arduino.cc ).

Techniques: