Journal: iScience

Article Title: Chronic random sleep deprivation causes prolonged pain hypersensitivity via the anterior cingulate cortex

doi: 10.1016/j.isci.2026.114750

Figure Lengend Snippet: Mirogabalin administration restored pinch-induced neuronal activation and the mechanical hypersensitivity in RSD-hyperalgesic mice (A) Representative traces showing ACC neuronal responses to pinch stimulation in control saline-treated RSD-hyperalgesic mice ( top ) and mirogabalin-treated RSD-hyperalgesic mice ( bottom ) 4 h after administrations. (B) Summary data showing effects of mirogabalin application on ACC neuronal responses normalized with basal firing rate ( upper : responses during pinch stimulation, below : responses after pinch stimulation for 10 s; saline n = 13 cells, 3 mice; mirogabalin n = 9 cells, 3 mice, one-way repeated measures ANOVA with Dunnett’s multiple comparisons test, ∗ p < 0.05, ∗ ∗∗p < 0.001). (C) Effect of mirogabalin application on mechanical threshold of control (non-sleep derived) mice ( n = 6 each). (D) Effect of mirogabalin application on mechanical hypersensitivity exhibited in RSD mice at the end of SD exposure ( n = 10 each, two-way repeated measures ANOVA with Bonferroni’s multiple comparisons test, ∗∗ p < 0.01, ∗ ∗∗∗p < 0.0001). (E) Effect of mirogabalin application on mechanical hypersensitivity exhibited in RSD mice 4 w after the end of SD (mirogabalin, n = 8; saline, n = 7, two-way repeated measures ANOVA with Bonferroni’s multiple comparisons test, ∗∗ p < 0.01, ∗ ∗∗∗p < 0.0001). (F) Effect of diclofenac application on mechanical hypersensitivity exhibited in RSD mice 4 w after the end of SD ( n = 10). Data are the mean ± SEM. See also .

Article Snippet: Diclofenac , MedChemExpress , Cat # HY-1503.

Techniques: Activation Assay, Control, Saline, Derivative Assay

Journal: The Science of the total environment

Article Title: An integrated approach for the assessment of the electrochemical oxidation of diclofenac: By-product identification, microbiological and eco-genotoxicological evaluation.

doi: 10.1016/j.scitotenv.2023.168511

Figure Lengend Snippet: Fig. 6. Variation of the logarithm of the concentration of Gram-negative (A and B) and Gram-positive (C and D) bacteria with treatment time (from 0 to 210 min) upon EO of 250 mL of simulated wastewater, simultaneously contaminated by diclofenac (DCF) and bacteria (blu bars). The same experiment was performed without diclofenac (orange bars). The bars represent the standard deviation of the mean.

Article Snippet: Diclofenac sodium salt (CAS: 15307-79-6) was purchased from Alfa Aesar (Ward Hill, Massachusetts, USA).

Techniques: Concentration Assay, Bacteria, Standard Deviation

Journal: The Science of the total environment

Article Title: An integrated approach for the assessment of the electrochemical oxidation of diclofenac: By-product identification, microbiological and eco-genotoxicological evaluation.

doi: 10.1016/j.scitotenv.2023.168511

Figure Lengend Snippet: Fig. 7. Logarithm of bacteria concentration (CFU mL−1) in aqueous suspensions of 0.02 M NaCl and 10 mg L−1 diclofenac previously treated (blue bars) and not treated (orange bars) with EO for 210 min. The viable count was performed at time zero (T0) and after 1 (T1) and 4 (T4) hours of incubation. A. E. coli; B. P. aeruginosa; C. E. hirae; D. B. atrophaeus. The bars represent the standard deviation of the mean.

Article Snippet: Diclofenac sodium salt (CAS: 15307-79-6) was purchased from Alfa Aesar (Ward Hill, Massachusetts, USA).

Techniques: Bacteria, Concentration Assay, Incubation, Standard Deviation

Journal: The Science of the total environment

Article Title: An integrated approach for the assessment of the electrochemical oxidation of diclofenac: By-product identification, microbiological and eco-genotoxicological evaluation.

doi: 10.1016/j.scitotenv.2023.168511

Figure Lengend Snippet: Fig. 11. Induction of DNA strand breaks in C. dubia observed by Comet assay Results are expressed as % DNA in tail and are from two independent experiments (400 nuclei) testing pure DCF (mg L−1) and Treated sample (%). Significantly differences between untreated and treated diclofenac samples were analysed by the Unpaired t-test for **p < 0.01.

Article Snippet: Diclofenac sodium salt (CAS: 15307-79-6) was purchased from Alfa Aesar (Ward Hill, Massachusetts, USA).

Techniques: Single Cell Gel Electrophoresis

Journal: The Science of the total environment

Article Title: An integrated approach for the assessment of the electrochemical oxidation of diclofenac: By-product identification, microbiological and eco-genotoxicological evaluation.

doi: 10.1016/j.scitotenv.2023.168511

Figure Lengend Snippet: Fig. 12. Relative expression levels of MnSOD (A), Cu/ZnSOD (B) e CAT (C) under acute concentration/dilution of DCF and treated sample (8 mg L−1/80 %) in C. dubia. Significantly difference between untreated and treated diclofenac samples were analysed by the Unpaired t-test for **p < 0.001.

Article Snippet: Diclofenac sodium salt (CAS: 15307-79-6) was purchased from Alfa Aesar (Ward Hill, Massachusetts, USA).

Techniques: Expressing, Concentration Assay

Journal: Dalton transactions (Cambridge, England : 2003)

Article Title: Layered gadolinium hydroxides for simultaneous drug delivery and imaging.

doi: 10.1039/c7dt03729e

Figure Lengend Snippet: Fig. 1. The chemical structures of the anions of diclofenac, ibuprofen, and naproxen.

Article Snippet: Diclofenac sodium and naproxen sodium were procured from Acros Organics, while ibuprofen sodium was obtained from Santa Cruz Biotechnology.

Techniques:

Journal: Pharmaceutical Drug Regulatory Affairs Journal

Article Title: Comparative Pharmacokinetic Studies of Marketed Gel and Transdermal Patches Loaded with Diclofenac Diethylamine in Rabbits

doi: 10.23880/pdraj-16000133

Figure Lengend Snippet: Figure 1: structure of Diclofenac Diethylamine (DDEA).

Article Snippet: Diclofenac Diethylamine was a gift sample from Santa Cruz, Mumbai.

Techniques:

Journal: Tropical Journal of Pharmaceutical Research

Article Title: Ispaghula Husk-Based Extended Release Tablets of Diclofenac Sodium: Formulation, Evaluation and In vitro Release Studies

doi: 10.4314/tjpr.v13i2.6

Figure Lengend Snippet: Figure 1: FTIR spectra of isapgol husk (A), diclofenac sodium (B) and formulated tablet (C)

Article Snippet: Differential scanning calorimetry (DSC) analysis of diclofenac sodium and powdered tablets were done using Perkin-Elmer DSC7 model.

Techniques: