cym50358 Search Results


cym50358  (MedChemExpress)
93
MedChemExpress cym50358
Cym50358, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 93 stars, based on 1 article reviews
cym50358 - by Bioz Stars, 2026-02
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s1pr4 antagonist  (Tocris)
93
Tocris s1pr4 antagonist
S1pr4 Antagonist, supplied by Tocris, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 93 stars, based on 1 article reviews
s1pr4 antagonist - by Bioz Stars, 2026-02
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cym50358 hydrochloride  (Tocris)
90
Tocris cym50358 hydrochloride
Neutralization of the <t>S1P4</t> receptor does not affect the Schwann cell phenotype. qRT-PCR based quantification of gene expression upon application of an S1P4 antagonist (S1P4 A, <t>CYM50358)</t> alone as well as in combination with Fingolimod (FTY + S1P4 A) revealed no effect on the expression of GAP43 ( A ), PDGF-BB ( B ), Mal ( C ), Tyrp1 ( D ), Krox20 ( E ) and Oct-6 ( F ) whereas Fingolimod alone led to the typical expression pattern of all markers. For statistical analysis, a one-way ANOVA with Tukey’s multiple comparison test was used, * p < 0.05, ** p < 0.01, *** p < 0.001 ( n = 3).
Cym50358 Hydrochloride, supplied by Tocris, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/cym50358 hydrochloride/product/Tocris
Average 90 stars, based on 1 article reviews
cym50358 hydrochloride - by Bioz Stars, 2026-02
90/100 stars
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cym50358  (Hycultec Inc)
90
Hycultec Inc cym50358
Neutralization of the <t>S1P4</t> receptor does not affect the Schwann cell phenotype. qRT-PCR based quantification of gene expression upon application of an S1P4 antagonist (S1P4 A, <t>CYM50358)</t> alone as well as in combination with Fingolimod (FTY + S1P4 A) revealed no effect on the expression of GAP43 ( A ), PDGF-BB ( B ), Mal ( C ), Tyrp1 ( D ), Krox20 ( E ) and Oct-6 ( F ) whereas Fingolimod alone led to the typical expression pattern of all markers. For statistical analysis, a one-way ANOVA with Tukey’s multiple comparison test was used, * p < 0.05, ** p < 0.01, *** p < 0.001 ( n = 3).
Cym50358, supplied by Hycultec Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/cym50358/product/Hycultec Inc
Average 90 stars, based on 1 article reviews
cym50358 - by Bioz Stars, 2026-02
90/100 stars
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Neutralization of the S1P4 receptor does not affect the Schwann cell phenotype. qRT-PCR based quantification of gene expression upon application of an S1P4 antagonist (S1P4 A, CYM50358) alone as well as in combination with Fingolimod (FTY + S1P4 A) revealed no effect on the expression of GAP43 ( A ), PDGF-BB ( B ), Mal ( C ), Tyrp1 ( D ), Krox20 ( E ) and Oct-6 ( F ) whereas Fingolimod alone led to the typical expression pattern of all markers. For statistical analysis, a one-way ANOVA with Tukey’s multiple comparison test was used, * p < 0.05, ** p < 0.01, *** p < 0.001 ( n = 3).

Journal: International Journal of Molecular Sciences

Article Title: Modulation of Specific Sphingosine-1-Phosphate Receptors Augments a Repair Mediating Schwann Cell Phenotype

doi: 10.3390/ijms231810311

Figure Lengend Snippet: Neutralization of the S1P4 receptor does not affect the Schwann cell phenotype. qRT-PCR based quantification of gene expression upon application of an S1P4 antagonist (S1P4 A, CYM50358) alone as well as in combination with Fingolimod (FTY + S1P4 A) revealed no effect on the expression of GAP43 ( A ), PDGF-BB ( B ), Mal ( C ), Tyrp1 ( D ), Krox20 ( E ) and Oct-6 ( F ) whereas Fingolimod alone led to the typical expression pattern of all markers. For statistical analysis, a one-way ANOVA with Tukey’s multiple comparison test was used, * p < 0.05, ** p < 0.01, *** p < 0.001 ( n = 3).

Article Snippet: All substances were dissolved in DMSO (Sigma-Aldrich) unless otherwise stated: 7.5 μM Ponesimod (S1P1 agonist, Selleckchem, Houston, TX, USA); 15 μM EX26 (S1P1 antagonist, Tocris Bioscience, Bristol, UK); 5 μM CYM5541 (S1P3 agonist, Tocris); 5 μM TY52156 (S1P3 antagonist, Tocris), 1.25 μM, 2.5 μM, 5 μM and 10 μM CYM50260 (S1P4 agonist, Tocris); 1 μM CYM50358 hydrochloride (S1P4 antagonist, Tocris); 1.25 μM, 2.5 μM, 5 μM, and 10 μM A971432 (S1P5 agonist, Tocris, solved in 1N HCl).

Techniques: Neutralization, Quantitative RT-PCR, Gene Expression, Expressing, Comparison