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Image Search Results
Journal: Scientific reports
Article Title: Simultaneously targeting inflammatory response and parasite sequestration in brain to treat Experimental Cerebral Malaria.
doi: 10.1038/srep12671
Figure Lengend Snippet: Figure 4. Curcumin suppressed markers of inflammation in the brain. P. berghei-infected mice were treated with curcumin as described in Fig. 1 and qPCR analysis was carried out on day 7 post infection from RNA isolated from brain or olfactory bulb. (a) CXCR3, CXCL9, CXCL10, granzyme B and CD8β in brain. (b) Inflammatory cytokines and cell adhesion molecule in the brain. (c) Inflammatory chemokine receptor and its ligands in olfactory bulb. The data are normalized to 18S rRNA and given as fold changes with respect to RNA from the brain of uninfected animals. The experiments were repeated thrice.
Article Snippet:
Techniques: Infection, Isolation
Journal: Scientific reports
Article Title: Simultaneously targeting inflammatory response and parasite sequestration in brain to treat Experimental Cerebral Malaria.
doi: 10.1038/srep12671
Figure Lengend Snippet: Figure 8. Effect of AC treatment on survival and associated markers after the onset of symptoms of ECM. Curcumin, AE and AC treatments were given beyond 12 h after the onset of symptoms (day 8 or 9 post infection) but before the coma stage. (a) Effect of drug treatments on survival of mice. AE was used at different sub-optimal concentrations ranging from 250 μ g to 650 μ g and given as a single injection. Curcumin was given in 3 oral doses. Survival curve analysis was carried out by Kaplan-Meier plot and P values calculated by Log- rank (Mantel-Cox) test. The experiment was carried out with 5 animals in each group and the experiment repeated twice. (b) Parasitemia in blood of the drug treated animals. (c) RT-PCR analysis of parasite 18S rRNA, CXCL10 and TNFα in the brain in the early stage after the drug treatments (day 12, AE 650 μ g). The experiment was repeated twice and the data represent mean ± SD from five animals in each group.
Article Snippet:
Techniques: Infection, Injection, Reverse Transcription Polymerase Chain Reaction