Journal: Xenobiotica; the fate of foreign compounds in biological systems

Article Title: Disposition of the emerging brominated flame retardant, bis(2-ethylhexyl) tetrabromophthalate, in female Sprague Dawley rats: effects of dose, route, and repeated administration

doi: 10.1080/00498254.2016.1174793

Figure Lengend Snippet: Chemical structure of (A) BEH-TEBP and (B) TBMEHP; *[14C]-radiolabel on a single carbonyl carbon.

Article Snippet: Chemicals [ 14 C]-radiolabeled BEH-TEBP (carboxy-labeled; ) was purchased from Moravek Biochemicals, Inc. (La Brea, CA).

Techniques:

Journal: Xenobiotica; the fate of foreign compounds in biological systems

Article Title: Disposition of the emerging brominated flame retardant, bis(2-ethylhexyl) tetrabromophthalate, in female Sprague Dawley rats: effects of dose, route, and repeated administration

doi: 10.1080/00498254.2016.1174793

Figure Lengend Snippet: Cumulative elimination of [14C]-radioactivity following a single administration of BEH-TEBP. N=4 per dose group, mean ± S.D. A: Recovery in urine, B: Recovery in feces (◆: 0.1 μmol/kg, PO, mouse; ▼: 0.1 μmol/kg, IV, rat; ▲:0.1 μmol/kg, oral, rat; ■: 10 μmol/kg, oral, rat).

Article Snippet: Chemicals [ 14 C]-radiolabeled BEH-TEBP (carboxy-labeled; ) was purchased from Moravek Biochemicals, Inc. (La Brea, CA).

Techniques: Radioactivity

Journal: Xenobiotica; the fate of foreign compounds in biological systems

Article Title: Disposition of the emerging brominated flame retardant, bis(2-ethylhexyl) tetrabromophthalate, in female Sprague Dawley rats: effects of dose, route, and repeated administration

doi: 10.1080/00498254.2016.1174793

Figure Lengend Snippet: [ 14 C]-radioactivity in selected tissues and excreta following a single BEH-TEBP administration (72 h post dose).

Article Snippet: Chemicals [ 14 C]-radiolabeled BEH-TEBP (carboxy-labeled; ) was purchased from Moravek Biochemicals, Inc. (La Brea, CA).

Techniques:

Journal: Xenobiotica; the fate of foreign compounds in biological systems

Article Title: Disposition of the emerging brominated flame retardant, bis(2-ethylhexyl) tetrabromophthalate, in female Sprague Dawley rats: effects of dose, route, and repeated administration

doi: 10.1080/00498254.2016.1174793

Figure Lengend Snippet: Cumulative elimination of [14C]-radioactivity following repeated administration of BEH-TEBP to female SD rats. N=4 per dose group, mean ± S.D. A: Recovery in urine, B: Recovery in feces.

Article Snippet: Chemicals [ 14 C]-radiolabeled BEH-TEBP (carboxy-labeled; ) was purchased from Moravek Biochemicals, Inc. (La Brea, CA).

Techniques: Radioactivity

Journal: Xenobiotica; the fate of foreign compounds in biological systems

Article Title: Disposition of the emerging brominated flame retardant, bis(2-ethylhexyl) tetrabromophthalate, in female Sprague Dawley rats: effects of dose, route, and repeated administration

doi: 10.1080/00498254.2016.1174793

Figure Lengend Snippet: [ 14 C]-radioactivity in selected tissues following single or repeated oral BEH-TEBP administration (0.1 μmol/kg/day, 24 h after final dose).

Article Snippet: Chemicals [ 14 C]-radiolabeled BEH-TEBP (carboxy-labeled; ) was purchased from Moravek Biochemicals, Inc. (La Brea, CA).

Techniques:

Journal: Xenobiotica; the fate of foreign compounds in biological systems

Article Title: Disposition of the emerging brominated flame retardant, bis(2-ethylhexyl) tetrabromophthalate, in female Sprague Dawley rats: effects of dose, route, and repeated administration

doi: 10.1080/00498254.2016.1174793

Figure Lengend Snippet: Representative HPLC-radiochromatograms of [14C]-radioactivity in excreta & bile following BEH-TEBP administration (0.1 μmol/kg) to female SD rats. A: [14C]-BEH-TEBP standard. B: [14C]-radioactivity in fecal extracts after oral administration. C: [14C]-radioactivity in bile after BEH-TEBP IV administration. D: [14C]-radioactivity in fecal extracts after BEH-TEBP IV administration.

Article Snippet: Chemicals [ 14 C]-radiolabeled BEH-TEBP (carboxy-labeled; ) was purchased from Moravek Biochemicals, Inc. (La Brea, CA).

Techniques: Radioactivity

Journal: Xenobiotica; the fate of foreign compounds in biological systems

Article Title: Disposition of the emerging brominated flame retardant, bis(2-ethylhexyl) tetrabromophthalate, in female Sprague Dawley rats: effects of dose, route, and repeated administration

doi: 10.1080/00498254.2016.1174793

Figure Lengend Snippet: Representative mass spectra of bile following BEH-TEBP (0.1 μmol/kg) administration by IV to female SD rats. A: Total ion chromatogram for bile after UPLC separation. B: Full-scale extracted ion chromatograms for peak eluting at 2.226 min, m/z of 296.6 Da is consistent with that of a doubly charged TBMEHP [M+H]− ion (inset, lower abundance singly charged TBMEHP [M+H]− ion). C: Full-scale extracted ion chromatograms for peak eluting at 2.259 min m/z of 288.7 Da is consistent with that of a doubly charged demethylated TBMEHP [M+H]− ion (inset, lower abundance singly charged demethylated TBMEHP [M+H]− ion).

Article Snippet: Chemicals [ 14 C]-radiolabeled BEH-TEBP (carboxy-labeled; ) was purchased from Moravek Biochemicals, Inc. (La Brea, CA).

Techniques: