computer-based simulation Search Results


computer-based simulation  (Simcyp)
90
Simcyp computer-based simulation
Time-course of <t>erlotinib</t> depletion (A) and formation of desmethyl erlotinib (B) in primary cultures of human hepatocytes treated with DMSO (○), ritonavir (●) or ketoconazole (□). Data are representative of three to six individual experiments each performed in duplicate. Error bars represent standard deviation.
Computer Based Simulation, supplied by Simcyp, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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computer-based simulation simcyp  (Simcyp)
90
Simcyp computer-based simulation simcyp
Time-course of <t>erlotinib</t> depletion (A) and formation of desmethyl erlotinib (B) in primary cultures of human hepatocytes treated with DMSO (○), ritonavir (●) or ketoconazole (□). Data are representative of three to six individual experiments each performed in duplicate. Error bars represent standard deviation.
Computer Based Simulation Simcyp, supplied by Simcyp, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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computer-based simulators simbionix  (Simbionix Ltd)
90
Simbionix Ltd computer-based simulators simbionix
Time-course of <t>erlotinib</t> depletion (A) and formation of desmethyl erlotinib (B) in primary cultures of human hepatocytes treated with DMSO (○), ritonavir (●) or ketoconazole (□). Data are representative of three to six individual experiments each performed in duplicate. Error bars represent standard deviation.
Computer Based Simulators Simbionix, supplied by Simbionix Ltd, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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computer-based patient simulations  (Gartner Inc)
90
Gartner Inc computer-based patient simulations
Time-course of <t>erlotinib</t> depletion (A) and formation of desmethyl erlotinib (B) in primary cultures of human hepatocytes treated with DMSO (○), ritonavir (●) or ketoconazole (□). Data are representative of three to six individual experiments each performed in duplicate. Error bars represent standard deviation.
Computer Based Patient Simulations, supplied by Gartner Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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molecular mechanics-based docking simulation  (Chemical Computing Group)
90
Chemical Computing Group molecular mechanics-based docking simulation
Time-course of <t>erlotinib</t> depletion (A) and formation of desmethyl erlotinib (B) in primary cultures of human hepatocytes treated with DMSO (○), ritonavir (●) or ketoconazole (□). Data are representative of three to six individual experiments each performed in duplicate. Error bars represent standard deviation.
Molecular Mechanics Based Docking Simulation, supplied by Chemical Computing Group, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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modified computational design synthesis using simulation-based evalua- tion and constraint consistency for vehicle powertrain systems  (Evalua International Ltd Oy)
90
Evalua International Ltd Oy modified computational design synthesis using simulation-based evalua- tion and constraint consistency for vehicle powertrain systems
Time-course of <t>erlotinib</t> depletion (A) and formation of desmethyl erlotinib (B) in primary cultures of human hepatocytes treated with DMSO (○), ritonavir (●) or ketoconazole (□). Data are representative of three to six individual experiments each performed in duplicate. Error bars represent standard deviation.
Modified Computational Design Synthesis Using Simulation Based Evalua Tion And Constraint Consistency For Vehicle Powertrain Systems, supplied by Evalua International Ltd Oy, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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computer-based simulation model  (Innov X Systems)
90
Innov X Systems computer-based simulation model
Time-course of <t>erlotinib</t> depletion (A) and formation of desmethyl erlotinib (B) in primary cultures of human hepatocytes treated with DMSO (○), ritonavir (●) or ketoconazole (□). Data are representative of three to six individual experiments each performed in duplicate. Error bars represent standard deviation.
Computer Based Simulation Model, supplied by Innov X Systems, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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computer-based simulations  (Tandy Corporation)
90
Tandy Corporation computer-based simulations
Time-course of <t>erlotinib</t> depletion (A) and formation of desmethyl erlotinib (B) in primary cultures of human hepatocytes treated with DMSO (○), ritonavir (●) or ketoconazole (□). Data are representative of three to six individual experiments each performed in duplicate. Error bars represent standard deviation.
Computer Based Simulations, supplied by Tandy Corporation, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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computer-based simulations - by Bioz Stars, 2026-03
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agent-based computer simulation  (Great Basin Corp)
90
Great Basin Corp agent-based computer simulation
Time-course of <t>erlotinib</t> depletion (A) and formation of desmethyl erlotinib (B) in primary cultures of human hepatocytes treated with DMSO (○), ritonavir (●) or ketoconazole (□). Data are representative of three to six individual experiments each performed in duplicate. Error bars represent standard deviation.
Agent Based Computer Simulation, supplied by Great Basin Corp, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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computer-based molecular docking simulations  (Innopharmascreen Inc)
90
Innopharmascreen Inc computer-based molecular docking simulations
Time-course of <t>erlotinib</t> depletion (A) and formation of desmethyl erlotinib (B) in primary cultures of human hepatocytes treated with DMSO (○), ritonavir (●) or ketoconazole (□). Data are representative of three to six individual experiments each performed in duplicate. Error bars represent standard deviation.
Computer Based Molecular Docking Simulations, supplied by Innopharmascreen Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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computer-based simulator eus mentor  (Simbionix Ltd)
90
Simbionix Ltd computer-based simulator eus mentor
Time-course of <t>erlotinib</t> depletion (A) and formation of desmethyl erlotinib (B) in primary cultures of human hepatocytes treated with DMSO (○), ritonavir (●) or ketoconazole (□). Data are representative of three to six individual experiments each performed in duplicate. Error bars represent standard deviation.
Computer Based Simulator Eus Mentor, supplied by Simbionix Ltd, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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computer simulation of a vsi fed induction motor based on constant (v/f) operation  (Powersim Inc)
90
Powersim Inc computer simulation of a vsi fed induction motor based on constant (v/f) operation
Time-course of <t>erlotinib</t> depletion (A) and formation of desmethyl erlotinib (B) in primary cultures of human hepatocytes treated with DMSO (○), ritonavir (●) or ketoconazole (□). Data are representative of three to six individual experiments each performed in duplicate. Error bars represent standard deviation.
Computer Simulation Of A Vsi Fed Induction Motor Based On Constant (V/F) Operation, supplied by Powersim Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Image Search Results


Time-course of erlotinib depletion (A) and formation of desmethyl erlotinib (B) in primary cultures of human hepatocytes treated with DMSO (○), ritonavir (●) or ketoconazole (□). Data are representative of three to six individual experiments each performed in duplicate. Error bars represent standard deviation.

Journal: Drug Metabolism and Disposition

Article Title: Ritonavir and Efavirenz Significantly Alter the Metabolism of Erlotinib—an Observation in Primary Cultures of Human Hepatocytes That Is Relevant to HIV Patients with Cancer

doi: 10.1124/dmd.113.052100

Figure Lengend Snippet: Time-course of erlotinib depletion (A) and formation of desmethyl erlotinib (B) in primary cultures of human hepatocytes treated with DMSO (○), ritonavir (●) or ketoconazole (□). Data are representative of three to six individual experiments each performed in duplicate. Error bars represent standard deviation.

Article Snippet: Rakhit A, Pantze MP, Fettner S, Jones HM, Charoin JE, Riek M, Lum BL, Hamilton M. (2008) The effects of CYP3A4 inhibition on erlotinib pharmacokinetics: computer-based simulation (SimCYP) predicts in vivo metabolic inhibition.

Techniques: Standard Deviation

Area under the concentration-time curve for erlotinib depletion and desmethyl erlotinib formation in primary cultures of human hepatocytes treated with vehicle (DMSO), ritonavir, or ketoconazole and incubated with erlotinib (5 μ M)

Journal: Drug Metabolism and Disposition

Article Title: Ritonavir and Efavirenz Significantly Alter the Metabolism of Erlotinib—an Observation in Primary Cultures of Human Hepatocytes That Is Relevant to HIV Patients with Cancer

doi: 10.1124/dmd.113.052100

Figure Lengend Snippet: Area under the concentration-time curve for erlotinib depletion and desmethyl erlotinib formation in primary cultures of human hepatocytes treated with vehicle (DMSO), ritonavir, or ketoconazole and incubated with erlotinib (5 μ M)

Article Snippet: Rakhit A, Pantze MP, Fettner S, Jones HM, Charoin JE, Riek M, Lum BL, Hamilton M. (2008) The effects of CYP3A4 inhibition on erlotinib pharmacokinetics: computer-based simulation (SimCYP) predicts in vivo metabolic inhibition.

Techniques: Concentration Assay, Incubation

Half-life ( t 1/2 ), % erlotinib metabolized after 48 hours, M/P to AUC ratio, T max of desmethyl erlotinib, and apparent intrinsic clearance (CL int, app ) of erlotinib in primary cultures of human hepatocytes treated with vehicle (DMSO), ritonavir, or ketoconazole and incubated with erlotinib (5 μ M)

Journal: Drug Metabolism and Disposition

Article Title: Ritonavir and Efavirenz Significantly Alter the Metabolism of Erlotinib—an Observation in Primary Cultures of Human Hepatocytes That Is Relevant to HIV Patients with Cancer

doi: 10.1124/dmd.113.052100

Figure Lengend Snippet: Half-life ( t 1/2 ), % erlotinib metabolized after 48 hours, M/P to AUC ratio, T max of desmethyl erlotinib, and apparent intrinsic clearance (CL int, app ) of erlotinib in primary cultures of human hepatocytes treated with vehicle (DMSO), ritonavir, or ketoconazole and incubated with erlotinib (5 μ M)

Article Snippet: Rakhit A, Pantze MP, Fettner S, Jones HM, Charoin JE, Riek M, Lum BL, Hamilton M. (2008) The effects of CYP3A4 inhibition on erlotinib pharmacokinetics: computer-based simulation (SimCYP) predicts in vivo metabolic inhibition.

Techniques: Incubation

Time-course of erlotinib depletion (A) and formation of desmethyl erlotinib (B) in primary cultures of human hepatocytes treated with DMSO (○), efavirenz (●), or rifampin (□). Data are representative of three individual experiments each performed in duplicate. Error bars represent standard deviation.

Journal: Drug Metabolism and Disposition

Article Title: Ritonavir and Efavirenz Significantly Alter the Metabolism of Erlotinib—an Observation in Primary Cultures of Human Hepatocytes That Is Relevant to HIV Patients with Cancer

doi: 10.1124/dmd.113.052100

Figure Lengend Snippet: Time-course of erlotinib depletion (A) and formation of desmethyl erlotinib (B) in primary cultures of human hepatocytes treated with DMSO (○), efavirenz (●), or rifampin (□). Data are representative of three individual experiments each performed in duplicate. Error bars represent standard deviation.

Article Snippet: Rakhit A, Pantze MP, Fettner S, Jones HM, Charoin JE, Riek M, Lum BL, Hamilton M. (2008) The effects of CYP3A4 inhibition on erlotinib pharmacokinetics: computer-based simulation (SimCYP) predicts in vivo metabolic inhibition.

Techniques: Standard Deviation

Area under the concentration-time curve for erlotinib depletion and desmethyl erlotinib formation in primary cultures of human hepatocytes treated with vehicle (DMSO), efavirenz, or rifampin and incubated with erlotinib (5 μ M)

Journal: Drug Metabolism and Disposition

Article Title: Ritonavir and Efavirenz Significantly Alter the Metabolism of Erlotinib—an Observation in Primary Cultures of Human Hepatocytes That Is Relevant to HIV Patients with Cancer

doi: 10.1124/dmd.113.052100

Figure Lengend Snippet: Area under the concentration-time curve for erlotinib depletion and desmethyl erlotinib formation in primary cultures of human hepatocytes treated with vehicle (DMSO), efavirenz, or rifampin and incubated with erlotinib (5 μ M)

Article Snippet: Rakhit A, Pantze MP, Fettner S, Jones HM, Charoin JE, Riek M, Lum BL, Hamilton M. (2008) The effects of CYP3A4 inhibition on erlotinib pharmacokinetics: computer-based simulation (SimCYP) predicts in vivo metabolic inhibition.

Techniques: Concentration Assay, Incubation

Half-life ( t 1/2 ), % erlotinib metabolized after 8 and 24 hours, M/P to AUC ratio, T max of desmethyl erlotinib, and apparent intrinsic clearance (CL int, app ) of erlotinib in primary cultures of human hepatocytes treated with vehicle (DMSO), efavirenz, or rifampin and incubated with erlotinib (5 μ M)

Journal: Drug Metabolism and Disposition

Article Title: Ritonavir and Efavirenz Significantly Alter the Metabolism of Erlotinib—an Observation in Primary Cultures of Human Hepatocytes That Is Relevant to HIV Patients with Cancer

doi: 10.1124/dmd.113.052100

Figure Lengend Snippet: Half-life ( t 1/2 ), % erlotinib metabolized after 8 and 24 hours, M/P to AUC ratio, T max of desmethyl erlotinib, and apparent intrinsic clearance (CL int, app ) of erlotinib in primary cultures of human hepatocytes treated with vehicle (DMSO), efavirenz, or rifampin and incubated with erlotinib (5 μ M)

Article Snippet: Rakhit A, Pantze MP, Fettner S, Jones HM, Charoin JE, Riek M, Lum BL, Hamilton M. (2008) The effects of CYP3A4 inhibition on erlotinib pharmacokinetics: computer-based simulation (SimCYP) predicts in vivo metabolic inhibition.

Techniques: Incubation

Predicted human hepatic or oral clearance (CLhep or CLoral) of erlotinib from primary cultures of human hepatocytes treated with DMSO, ritonavir, or ketoconazole. *P < 0.05 versus DMSO; nonparametric Friedman analysis of variance followed by Dunn’s multiple comparison test.

Journal: Drug Metabolism and Disposition

Article Title: Ritonavir and Efavirenz Significantly Alter the Metabolism of Erlotinib—an Observation in Primary Cultures of Human Hepatocytes That Is Relevant to HIV Patients with Cancer

doi: 10.1124/dmd.113.052100

Figure Lengend Snippet: Predicted human hepatic or oral clearance (CLhep or CLoral) of erlotinib from primary cultures of human hepatocytes treated with DMSO, ritonavir, or ketoconazole. *P < 0.05 versus DMSO; nonparametric Friedman analysis of variance followed by Dunn’s multiple comparison test.

Article Snippet: Rakhit A, Pantze MP, Fettner S, Jones HM, Charoin JE, Riek M, Lum BL, Hamilton M. (2008) The effects of CYP3A4 inhibition on erlotinib pharmacokinetics: computer-based simulation (SimCYP) predicts in vivo metabolic inhibition.

Techniques: Comparison

Predicted human hepatic or oral clearance (CLhep or CLoral) of erlotinib from primary cultures of human hepatocytes treated with DMSO, efavirenz, or rifampin. *P < 0.05 versus DMSO; nonparametric Friedman analysis of variance followed by Dunn’s multiple comparison test.

Journal: Drug Metabolism and Disposition

Article Title: Ritonavir and Efavirenz Significantly Alter the Metabolism of Erlotinib—an Observation in Primary Cultures of Human Hepatocytes That Is Relevant to HIV Patients with Cancer

doi: 10.1124/dmd.113.052100

Figure Lengend Snippet: Predicted human hepatic or oral clearance (CLhep or CLoral) of erlotinib from primary cultures of human hepatocytes treated with DMSO, efavirenz, or rifampin. *P < 0.05 versus DMSO; nonparametric Friedman analysis of variance followed by Dunn’s multiple comparison test.

Article Snippet: Rakhit A, Pantze MP, Fettner S, Jones HM, Charoin JE, Riek M, Lum BL, Hamilton M. (2008) The effects of CYP3A4 inhibition on erlotinib pharmacokinetics: computer-based simulation (SimCYP) predicts in vivo metabolic inhibition.

Techniques: Comparison

The parameters used for the prediction of hepatic clearance and the comparisons of observed and predicted CL oral values for erlotinib with prediction errors Observed CL oral values (1.9, 3.3, 1.1, 5.3, 5.75, 4.08) were obtained from literature ( N = 6) ( Messersmith et al., 2004 ; Miller et al., 2007 ; Rudin et al., 2008 ; van Erp et al., 2009 ; Padda et al., 2012 ). Predicted CL oral values (0.853, 0.696, 0.997, 0.793, 0.651, 0.668) were obtained from six different vehicle-treated human hepatocytes.

Journal: Drug Metabolism and Disposition

Article Title: Ritonavir and Efavirenz Significantly Alter the Metabolism of Erlotinib—an Observation in Primary Cultures of Human Hepatocytes That Is Relevant to HIV Patients with Cancer

doi: 10.1124/dmd.113.052100

Figure Lengend Snippet: The parameters used for the prediction of hepatic clearance and the comparisons of observed and predicted CL oral values for erlotinib with prediction errors Observed CL oral values (1.9, 3.3, 1.1, 5.3, 5.75, 4.08) were obtained from literature ( N = 6) ( Messersmith et al., 2004 ; Miller et al., 2007 ; Rudin et al., 2008 ; van Erp et al., 2009 ; Padda et al., 2012 ). Predicted CL oral values (0.853, 0.696, 0.997, 0.793, 0.651, 0.668) were obtained from six different vehicle-treated human hepatocytes.

Article Snippet: Rakhit A, Pantze MP, Fettner S, Jones HM, Charoin JE, Riek M, Lum BL, Hamilton M. (2008) The effects of CYP3A4 inhibition on erlotinib pharmacokinetics: computer-based simulation (SimCYP) predicts in vivo metabolic inhibition.

Techniques:

Recovery of ritonavir-mediated inhibition (top) and efavirenz-mediated induction (bottom) of erlotinib metabolism in primary cultures of human hepatocytes. Data are representative of three individual experiments each performed in duplicate. Error bars represent standard deviation.

Journal: Drug Metabolism and Disposition

Article Title: Ritonavir and Efavirenz Significantly Alter the Metabolism of Erlotinib—an Observation in Primary Cultures of Human Hepatocytes That Is Relevant to HIV Patients with Cancer

doi: 10.1124/dmd.113.052100

Figure Lengend Snippet: Recovery of ritonavir-mediated inhibition (top) and efavirenz-mediated induction (bottom) of erlotinib metabolism in primary cultures of human hepatocytes. Data are representative of three individual experiments each performed in duplicate. Error bars represent standard deviation.

Article Snippet: Rakhit A, Pantze MP, Fettner S, Jones HM, Charoin JE, Riek M, Lum BL, Hamilton M. (2008) The effects of CYP3A4 inhibition on erlotinib pharmacokinetics: computer-based simulation (SimCYP) predicts in vivo metabolic inhibition.

Techniques: Inhibition, Standard Deviation