Journal: Quality of Life Research

Article Title: The use of PROMIS measures in clinical studies in patients with inflammatory arthritis: a systematic review

doi: 10.1007/s11136-023-03422-0

Figure Lengend Snippet: Characteristics and used PROMIS measures of clinical studies in patients with axSpA and RA

Article Snippet: Bartlett et al. 2018 g [ , ] , USA , 1 , 1 , 200 52 32 , 84.0 87.0 72.0 , Community: Creakyjoints.org Clinic: Johns Hopkins Arthritis Centre patients Clinics: Johns Hopkins, Hospital for Special Surgery, University of Alabama , 51.0 (12.0) 53.0 (14.0) 54.0 (13.0) , 10.0 (10.0) 15.0 (11.0) 13.0 (10.0) , , × , × , × , × , , , , , × , , × , .

Techniques: Biomarker Discovery

Journal: Environmental Epigenetics

Article Title: Association between DNA methylation profiles in leukocytes and serum levels of persistent organic pollutants in Dutch men

doi: 10.1093/eep/dvx001

Figure Lengend Snippet: characteristics of the study participants. Values are given as median (25–75 percentile) or number (percentage) of participants

Article Snippet: The seven indicator PCBs (sum of PCB-28, 52, 101, 118, 138, and 153), recommended by the European Union Community Bureau of Reference based on their relatively high concentrations in technical mixtures and their wide chlorination range, were measured with gas chromatography followed by electron-capture detection (GC-ECD) after liquid–liquid extraction and expressed per gram lipid [ ].

Techniques: DNA Methylation Assay

Journal: Environmental Epigenetics

Article Title: Association between DNA methylation profiles in leukocytes and serum levels of persistent organic pollutants in Dutch men

doi: 10.1093/eep/dvx001

Figure Lengend Snippet: General features of extensive DNA methylation associations with higher POP levels. (A) The fraction of hypo- (inverse association with POP levels) and hypermethylated (positively associated with POP levels) positions, based on the top 1000 most statistically significant positions, determined with a continuous analyses for serum levels of dioxins and dioxin-like compounds ( P values between 8.8E−07 and 3.5E−03), the sum of seven indicator PCBs ( P values between 1.8E−05 and 5.5E−03), and PFOS ( P values between 2.4E−06 and 3.0E−03). (B) Percentages of positions expressed in relationship to CpG density, for the top 1000 positions with the highest statistical significance, for the three POP groups (colored bars) as well as all considered positions on the Illumina 450K BeadChip (grey bars). ‘Islands’ indicate the CpG islands (CGI), ‘Shore’ the CGI shores (0-2 kb from CGI), ‘Shelf’ the CGI shelves (2–4 kb from CGI) and ‘Open sea’ the single positions outside CGIs

Article Snippet: The seven indicator PCBs (sum of PCB-28, 52, 101, 118, 138, and 153), recommended by the European Union Community Bureau of Reference based on their relatively high concentrations in technical mixtures and their wide chlorination range, were measured with gas chromatography followed by electron-capture detection (GC-ECD) after liquid–liquid extraction and expressed per gram lipid [ ].

Techniques: DNA Methylation Assay

Journal: Environmental Epigenetics

Article Title: Association between DNA methylation profiles in leukocytes and serum levels of persistent organic pollutants in Dutch men

doi: 10.1093/eep/dvx001

Figure Lengend Snippet: representative differentially methylated regions detected in leukocytes in relation to PFOS (DHRS4L2), the sum of seven indicator PCBs (ZNF85) and to dioxins and dioxin-like compounds expressed in BEQ (BRCA1/NBR2), although similar DMRs were detected in relation to the other POPs (see online for Tables S3–S5). Each dot represents methylation rate at the indicated position of individual samples and the lines show the average methylation levels. Analyses were based on continuous levels of the POPs; however, participants were categorized into two groups for visualization purposes. The light color represents the low-exposed group, while the dark color represents the high-exposed group based on the serum levels (median-split). Median (25–75 percentile) levels for the low- and the high-exposed group are 14.3 (6.9–33.6) and 96.9 (71.8–114) ng/g wet weight for PFOS, 246 (115–371) and 1635 (1095–2484) ng/g lipid for PCBs, and 17.1 (12.2–19.3), and 49.6 (35.2–70.7) for BEQ levels. 5’UTR, five prime untranslated region; Chr, chromosome; TSS200, 200 base pairs from the transcription start site; TSS1500, 1500 base pairs from the transcription start site

Article Snippet: The seven indicator PCBs (sum of PCB-28, 52, 101, 118, 138, and 153), recommended by the European Union Community Bureau of Reference based on their relatively high concentrations in technical mixtures and their wide chlorination range, were measured with gas chromatography followed by electron-capture detection (GC-ECD) after liquid–liquid extraction and expressed per gram lipid [ ].

Techniques: Methylation