Journal: Journal of Fungi

Article Title: Polyporenic Acids from the Mushroom Buglossoporus quercinus Possess Chemosensitizing and Efflux Pump Inhibitory Activities on Colo 320 Adenocarcinoma Cells

doi: 10.3390/jof9090923

Figure Lengend Snippet: P-gp efflux pump inhibitory activity of compounds 1 − 12 on the MDR Colo 320 colon adenocarcinoma cell line.

Article Snippet: The human colon adenocarcinoma cell lines, Colo 205 (ATCC-CCL-222) doxorubicin-sensitive and Colo 320/MDR-LRP (ATCC-CCL-220.1) resistant to doxorubicin expressing P-glycoprotein (ABCB1), were purchased from LGC Promochem (Teddington, UK).

Techniques: Activity Assay

Journal: Journal of Fungi

Article Title: Polyporenic Acids from the Mushroom Buglossoporus quercinus Possess Chemosensitizing and Efflux Pump Inhibitory Activities on Colo 320 Adenocarcinoma Cells

doi: 10.3390/jof9090923

Figure Lengend Snippet: Chemosensitizing activity of compounds 3 – 4 and 7 – 12 on Colo 320 adenocarcinoma cells.

Article Snippet: The human colon adenocarcinoma cell lines, Colo 205 (ATCC-CCL-222) doxorubicin-sensitive and Colo 320/MDR-LRP (ATCC-CCL-220.1) resistant to doxorubicin expressing P-glycoprotein (ABCB1), were purchased from LGC Promochem (Teddington, UK).

Techniques: Activity Assay

Journal: mAbs

Article Title: Insertion of scFv into the hinge domain of full-length IgG1 monoclonal antibody results in tetravalent bispecific molecule with robust properties

doi: 10.1080/19420862.2016.1270492

Figure Lengend Snippet: Tumor growth inhibition of Bs4Ab-VA, anti-VEGF and anti-Ang2, and their combination using a colon cancer (Colo205) mouse xenograft model. When the tumor reached a volume of approximately 200 mm3, mice (n = 6) were administered intraperitoneally twice per week for four weeks with 14 mg/kg of Bs4Ab-VA, 10 mg/kg of anti-VEGF, anti-Ang2, their combination, and a non-binding isotype antibody. Untreated mice were used as control. 10 mg/kg of each of the two parental antibodies were used for the combination study.

Article Snippet: 5 × 10 6 Colo205 cells in 50% matrigel were inoculated subcutaneously on the right flank into 5- to 6-weeks old female athymic nude mice (Harlan Laboratories).

Techniques: Inhibition, Binding Assay