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Image Search Results
Journal: American Journal of Physiology - Gastrointestinal and Liver Physiology
Article Title: Molecular characterization of a precision-cut rat liver slice model for the evaluation of antifibrotic compounds
doi: 10.1152/ajpgi.00281.2018
Figure Lengend Snippet: ELISA analysis of secreted biomarkers. SB525334, nintedanib, and sorafenib suppressed secretion of hyaluronic acid (HA), insulin-like growth factor binding protein 5 (IGFBP5), and WNT1-inducible signaling pathway protein 1 (WISP1) in the conditioned medium after 48 h of incubation. Data are means ± SE; n = 3 rats for both sham and bile duct ligation (BDL); n = 8–10 liver slices for each condition. **P < 0.01 and ***P < 0.001.
Article Snippet: Secreted biomarkers including procollagen I, HA,
Techniques: Enzyme-linked Immunosorbent Assay, Binding Assay, Incubation, Ligation
Journal: American Journal of Physiology - Gastrointestinal and Liver Physiology
Article Title: Molecular characterization of a precision-cut rat liver slice model for the evaluation of antifibrotic compounds
doi: 10.1152/ajpgi.00281.2018
Figure Lengend Snippet: The small molecule αV integrins inhibitor CWHM12 attenuated fibrotic phenotype in fibrotic precision-cut liver tissue slices (PCLSs) after 48 h of incubation. A: CWHM12 suppressed expression of a panel of fibrotic genes. B: CWHM12 decreased secretion of procollagen I, hyaluronic acid (HA), insulin-like growth factor binding protein 5 (IGFBP5), and WNT1-inducible signaling pathway protein 1 (WISP1) in the conditioned medium. Data are means ± SE; n = 3 rats for both sham and bile duct ligation (BDL); n = 6–8 liver slices for each condition. *P < 0.05, **P < 0.01, ***P < 0.001.
Article Snippet: Secreted biomarkers including procollagen I, HA,
Techniques: Incubation, Expressing, Binding Assay, Ligation