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Image Search Results
Journal: International Journal of Molecular Sciences
Article Title: SIGLEC-5/14 Inhibits CD11b/CD18 Integrin Activation and Neutrophil-Mediated Tumor Cell Cytotoxicity
doi: 10.3390/ijms242417141
Figure Lengend Snippet: Immune receptors SIGLEC-5 and SIGLEC-14, and enzymes responsible for the biosynthesis of sialic acids are highly co-expressed in the tumor microenvironment. ( a , b ) Histograms from one representative example depict the expression of SIGLEC-5/14 ( a ) or SIGLEC-14 ( b ) in whole blood-derived CD19-positive B cells, CD16-positive neutrophils, CD3-positive T cells, CD56-positive NK cells, or CD14-positive monocytes. Histograms are shown as normalized to mode. ( c ) mRNA data expression of SIGLEC-5 and SIGLEC-14 genes in breast, ovarian, pancreatic, or melanoma cancers, normalized to healthy tissue. ( d ) mRNA data expression of genes regulating sialic acid metabolism in breast, ovarian, pancreatic, and melanoma cancers, normalized to healthy tissue. ( c , d ) GTEx vs. TCGA databases; normalized to GTEX).
Article Snippet: The plasmid vectors pRRL PPT SFFV prester SIN (pSIN) contained SIGLEC-5-HA IRES GFP or
Techniques: Expressing, Derivative Assay