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Image Search Results
Journal:
Article Title: Selective Expression of Murine Prostate Stem Cell Antigen in Fetal and Adult Tissues and the Transgenic Adenocarcinoma of the Mouse Prostate Model of Prostate Carcinogenesis
doi:
Figure Lengend Snippet: Expression of murine PSCA in prostate tissue of the TRAMP model by in situ hybridization. Bright field (A, C, E, G) and dark field (B, D, F, H) are shown for each frame. A and B: Prostatic duct with PSCA-positive PIN (arrow) and PSCA-negative PIN (arrowhead) and normal prostatic epithelia (thin arrowhead) (original magnification, ×200). C and D: Widespread but variable expression in well-differentiated adenocarcinoma (original magnification, ×40). E and F: Areas of PSCA expression in moderately differentiated adenocarcinoma. PSCA-positive cells are adjacent to morphologically similar PSCA-negative cells. G and H: PSCA-negative poorly differentiated carcinoma with trapped PSCA-positive duct showing PIN (arrow).
Article Snippet: The histological grade of prostate cancer was determined in accordance to previously published studies in the TRAMP model. 10 Cloning of the Murine PSCA Orthologue Full-length cDNA for
Techniques: Expressing, In Situ Hybridization
Journal:
Article Title: Selective Expression of Murine Prostate Stem Cell Antigen in Fetal and Adult Tissues and the Transgenic Adenocarcinoma of the Mouse Prostate Model of Prostate Carcinogenesis
doi:
Figure Lengend Snippet: Expression of murine PSCA in fetal tissues by in situ hybridization. Bright field (A, C, E, G) and dark field (B, D, F, H) are shown for each frame. Original magnification ×200 for all images. A and B: PSCA expression is most intense in the superficial epithelial cells (arrow) of the urogenital sinus of an E15 embryo. The more basally located epithelial cells are low or negative for PSCA expression (arrowhead). C and D: Fetal skin is positive for PSCA (arrow) at E15, whereas the basal cells are negative (arrowhead). E and F: The squamous epithelium of the embryonic esophagus is very strongly positive for PSCA at E18 (arrow). The basal cells of the esophageal epithelium are negative (arrowhead). H and G: The transitional squamous portions of the anal canal show strong signal in the superficial cell layers (arrow), basally located epithelial cells are negative (arrowhead).
Article Snippet: The histological grade of prostate cancer was determined in accordance to previously published studies in the TRAMP model. 10 Cloning of the Murine PSCA Orthologue Full-length cDNA for
Techniques: Expressing, In Situ Hybridization