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Image Search Results
Journal: bioRxiv
Article Title: RO8191, a new compound for initiating embryo implantation in mice
doi: 10.1101/2024.09.30.615945
Figure Lengend Snippet: (A) The experimental procedure of the artificial DI mouse. Ovariectomy (OVX) and subcutaneous administration of siliconized medroxyprogesterone acetate (MPA) were performed on D3. A single injection of oil or RO8191 was performed on D7. Females were euthanized and dissected on D10. (B) Representative images of the gross uterine morphology. Blastocysts were recovered from oil-treated mice (white arrowheads). Implantation sites (yellow arrowheads on right panel) were visible in DI mice after RO8191 treatment. Scale bars: 1 cm for uterine images and 200 μm for blastocysts. (C, D) Implantation rate (C) and the number of implantation sites (D) in the oil and RO8191-treated DI mice. * indicates significantly different (p < 0.0001). (E) Representative histological image of uterine cross-sections of implantation sites on D10 after RO8191 treatment in DI mice. Right panels are higher magnification of left panels indicated by yellow line. Lower panels indicated abnormal embryo development and decidual reaction. Scale bars: 100 μm. dec: decidua; em: embryo.
Article Snippet: The
Techniques: Injection
Journal: bioRxiv
Article Title: RO8191, a new compound for initiating embryo implantation in mice
doi: 10.1101/2024.09.30.615945
Figure Lengend Snippet: (A) The experimental procedure of the genetically modified mice. For control, a single oil injection was performed on D4. For cKOs, a single injection of oil or RO8191 was performed on D4. Females were euthanized and dissected on D7. (B-D) Uterine morphology of cKOs mice after the injection of oil or RO8191. The white arrowheads indicate the presumptive implantation site. Scale bars: 1 cm. (E) The implantation rate in cKOs mice after oil or RO8191 administration. (F) The number of implantation sites in cKOs mice after the injection of oil or RO8191. (G) The size of implantation sites in cKOs mice after oil or RO8191 administration. * indicates significantly different (p < 0.05).
Article Snippet: The
Techniques: Genetically Modified, Control, Injection
Journal: bioRxiv
Article Title: RO8191, a new compound for initiating embryo implantation in mice
doi: 10.1101/2024.09.30.615945
Figure Lengend Snippet: (A, B) Control ( Lifr f/f ) uterus after sesame oil treatment. (C, D) Stat3 cKO, (E, F) Gp130 cKO, and (G, H) Lifr cKO uterus after RO8191 treatment. Higher magnification in yellow frames inserted in D and F. Scale bar, 100 µm. dec: decidua; em: embryo; bv: blood vessels; le: luminal epithelium; li: leukocyte infiltration.
Article Snippet: The
Techniques: Control