cd38 inhibitor 1 Search Results


78c  (MedChemExpress)
94
MedChemExpress 78c
<t>78c</t> suppresses aging‐associated inflammation and tissue function decline. Comparison of aged (24 months old) WT mice treated with or without 78c for 2 months. (A–C), Quantitative real‐time PCR analyses for the mRNA levels of the indicated genes in the GA (A, n = 7,6), the liver (B, n = 6) and the hippocampus (C, n = 7). (D–G), Immunostaining for CD68+ cells and quantification of the GA (D, E, n = 7) and the liver (F, G, n = 7,6) sections. Scale bar: 50 μm. 5 images examined from 3 slides/mouse. (H, I), Immunostaining for phosphorylated STING and quantification of the GA sections. Scale bar: 30 μm. n = 7.4 images examined from 3 slides/mouse. (J, K), Western blotting analyses and quantification of TBK1 and phosphorylated TBK1 in the liver. GAPDH was used as a control. n = 3. (L, M), Levels of TNF‐α and IL‐6 in the serum. n = 6. (N), Latency to fall in the grip strength test. n = 10. (O), Time spent in the target quadrant in the Barnes maze test. n = 10, 9. Data are mean ± s.e.m. * p < 0.05. ** p < 0.01. *** p < 0.001. Student's t test.
78c, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/cd38+inhibitor+1/CD38+inhibitor+1/pmc12419836-57-0-1
Average 94 stars, based on 1 article reviews
78c - by Bioz Stars, 2026-09
94/100 stars
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cd38 inhibitor 1  (MuseChem Chemicals)
N/A
CD38 Inhibitor 1（Cat No.:I019171） is a high-purity compound essential for advanced pharmaceutical and biochemical research. It is specifically designed to inhibit CD38, an enzyme involved in NAD+ metabolism and calcium signaling. This inhibitor is crucial
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cd38 inhibitor 1  (Selleck Chemicals)
93
Selleck Chemicals cd38 inhibitor 1
<t>78c</t> suppresses aging‐associated inflammation and tissue function decline. Comparison of aged (24 months old) WT mice treated with or without 78c for 2 months. (A–C), Quantitative real‐time PCR analyses for the mRNA levels of the indicated genes in the GA (A, n = 7,6), the liver (B, n = 6) and the hippocampus (C, n = 7). (D–G), Immunostaining for CD68+ cells and quantification of the GA (D, E, n = 7) and the liver (F, G, n = 7,6) sections. Scale bar: 50 μm. 5 images examined from 3 slides/mouse. (H, I), Immunostaining for phosphorylated STING and quantification of the GA sections. Scale bar: 30 μm. n = 7.4 images examined from 3 slides/mouse. (J, K), Western blotting analyses and quantification of TBK1 and phosphorylated TBK1 in the liver. GAPDH was used as a control. n = 3. (L, M), Levels of TNF‐α and IL‐6 in the serum. n = 6. (N), Latency to fall in the grip strength test. n = 10. (O), Time spent in the target quadrant in the Barnes maze test. n = 10, 9. Data are mean ± s.e.m. * p < 0.05. ** p < 0.01. *** p < 0.001. Student's t test.
Cd38 Inhibitor 1, supplied by Selleck Chemicals, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/cd38+inhibitor+1/CD38+inhibitor+1/pm33171124-260-11-19
Average 93 stars, based on 1 article reviews
cd38 inhibitor 1 - by Bioz Stars, 2026-09
93/100 stars
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cd38 inhibitor 1  (TargetMol)
N/A
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cd38 inhibitor 1  (Aladdin Scientific Corporation)
N/A
product description：A cell-permeable, orally bioavailable, non-toxic thiazolyl-quinolinone derived compound that acts as a potent, selective and reversible inhibitor of CD38 (IC50 = 7.3 & 1.9 nM for human & mouse CD38, respectively; Ki = 0.3
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Image Search Results


78c suppresses aging‐associated inflammation and tissue function decline. Comparison of aged (24 months old) WT mice treated with or without 78c for 2 months. (A–C), Quantitative real‐time PCR analyses for the mRNA levels of the indicated genes in the GA (A, n = 7,6), the liver (B, n = 6) and the hippocampus (C, n = 7). (D–G), Immunostaining for CD68+ cells and quantification of the GA (D, E, n = 7) and the liver (F, G, n = 7,6) sections. Scale bar: 50 μm. 5 images examined from 3 slides/mouse. (H, I), Immunostaining for phosphorylated STING and quantification of the GA sections. Scale bar: 30 μm. n = 7.4 images examined from 3 slides/mouse. (J, K), Western blotting analyses and quantification of TBK1 and phosphorylated TBK1 in the liver. GAPDH was used as a control. n = 3. (L, M), Levels of TNF‐α and IL‐6 in the serum. n = 6. (N), Latency to fall in the grip strength test. n = 10. (O), Time spent in the target quadrant in the Barnes maze test. n = 10, 9. Data are mean ± s.e.m. * p < 0.05. ** p < 0.01. *** p < 0.001. Student's t test.

Journal: Aging Cell

Article Title: SIRT2 and NAD + Boosting Broadly Suppress Aging‐Associated Inflammation

doi: 10.1111/acel.70162

Figure Lengend Snippet: 78c suppresses aging‐associated inflammation and tissue function decline. Comparison of aged (24 months old) WT mice treated with or without 78c for 2 months. (A–C), Quantitative real‐time PCR analyses for the mRNA levels of the indicated genes in the GA (A, n = 7,6), the liver (B, n = 6) and the hippocampus (C, n = 7). (D–G), Immunostaining for CD68+ cells and quantification of the GA (D, E, n = 7) and the liver (F, G, n = 7,6) sections. Scale bar: 50 μm. 5 images examined from 3 slides/mouse. (H, I), Immunostaining for phosphorylated STING and quantification of the GA sections. Scale bar: 30 μm. n = 7.4 images examined from 3 slides/mouse. (J, K), Western blotting analyses and quantification of TBK1 and phosphorylated TBK1 in the liver. GAPDH was used as a control. n = 3. (L, M), Levels of TNF‐α and IL‐6 in the serum. n = 6. (N), Latency to fall in the grip strength test. n = 10. (O), Time spent in the target quadrant in the Barnes maze test. n = 10, 9. Data are mean ± s.e.m. * p < 0.05. ** p < 0.01. *** p < 0.001. Student's t test.

Article Snippet: 78c (MedChemExpress LLC, #HY‐123999) was administered to mice by intraperitoneal injection (10 mg/kg/dose) twice daily.

Techniques: Comparison, Real-time Polymerase Chain Reaction, Immunostaining, Western Blot, Control