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Image Search Results
Journal: Exploration of Targeted Anti-tumor Therapy
Article Title: Changes of urinary immunity and microbiome after intravesical BCG therapy and their association with outcomes in NMIBC
doi: 10.37349/etat.2026.1002365
Figure Lengend Snippet: Time-course changes in mRNA expression of immune cell markers in urine. ΔCt values (relative to GAPDH ) for CD33 , PD-L1 ( CD274 ), PD-L2 ( PDCD1LG2 ), and CD204 ( MSR1 ) in urine sediment collected at four time points: before TURBT, before BCG induction, immediately after completion of six BCG instillations, and 3 months after BCG. CD33 increased immediately after BCG and remained elevated for 3 months, whereas CD204 significantly increased after BCG. PD-L1 and PD-L2 showed significant increases immediately after BCG treatment, with PD-L2 returning to baseline by 3 months. P values were obtained from paired Wilcoxon signed-rank tests versus the pre-TURBT baseline. ns: not significant; * P < 0.05; ** P < 0.01; *** P < 0.001. TURBT: transurethral resection of bladder tumor; BCG: Bacillus Calmette–Guérin.
Article Snippet: TaqMan assays (
Techniques: Expressing
Journal: Exploration of Targeted Anti-tumor Therapy
Article Title: Changes of urinary immunity and microbiome after intravesical BCG therapy and their association with outcomes in NMIBC
doi: 10.37349/etat.2026.1002365
Figure Lengend Snippet: Urinary microbiome-immune coupling. Matrix plot summarizing associations between immune-related gene expression (PD-L1 , PD-L2 , CD33 , and CD204 ) and microbiome indices, including phylum-level balances (Bal_) and taxon-specific log-abundances (_nb), across all four time points. Colors indicate the direction and magnitude of the mixed-effects model coefficient ( β ), and numbers in each cell show β (two significant digits). Coefficients ( β ) are from linear mixed-effects models with immune transcript levels (ΔCt) as outcomes and microbiome features as predictors, including a random intercept for participant. Taxon-specific features (nb) were entered as clr-transformed abundances (pseudocount = 1), whereas balance indices (Bal) were entered as predefined log-ratio/ilr features; fixed effects included timepoint and available clinical covariates (age, sex, antibiotics, UTI, stage, maintenance BCG). The symbol † indicates associations that met the exploratory false discovery rate threshold (Benjamini–Hochberg adjusted q < 0.10). Bal_ denotes the log-ratio between two taxonomic groups, and _nb denotes the log-abundance of a specific taxon. Bal_inflam = log[P/(F + B)]. P: Proteobacteria; F: Firmicutes; B: Bacteroidetes; A: Actinobacteria; Cory: Corynebacterium ; Staph: Staphylococcus ; Entero: Enterobacteriaceae; BCG: Bacillus Calmette–Guérin; UTI: urinary tract infection. The underlying numerical results ( β , P , and q values) are provided in .
Article Snippet: TaqMan assays (
Techniques: Gene Expression, Transformation Assay, Infection