cb-6644 Search Results


cb6644  (Cayman Chemical)
90
Cayman Chemical cb6644
(A) Hybridization chain reaction (HCR) imaging shows co-localization of ruvbl1 and ruvbl2 transcripts (magenta) with GFPd2 (green). Scale bar, 100 μm. (B) Schematic representation of the Vivo-Morpholino (Vivo-MO) injection strategy in regenerating adult caudal fins. Regenerative growth was quantified at 3 dpa by comparing the injected region (Area I ) to the uninjected control region (Area U ) within the same fin. (C) Representative images of adult fins at 1 dpa (pre-injection) and at 3 dpa following injection with control, ruvbl1 , or ruvbl2 Vivo-MOs at 1 and 2 dpa. Knockdown of ruvbl1 or ruvbl2 resulted in reduced regenerative outgrowth. Scale bar, 0.5 mm. (D) Violin plots showing percent regenerative growth across different conditions (****p<0.0001; **p<0.01). (E) Schematic representation of larval tail regeneration inhibitor treatment strategy. Tails were amputated at 3 dpf and regeneration was monitored in the presence of Ruvbl1/2 inhibitor <t>CB6644</t> from 0 to 4 dpa (3 to 7 dpf). (F) Representative images of regenerating larval tails treated with 1% DMSO (vehicle control) or CB6644 at 10, 25, or 50 μM. Scale bar, 100 μm. (G) Violin plots showing regenerative area (mm 2 ) across treatments (ns, not significant; *p<0.05; ****p<0.0001).
Cb6644, supplied by Cayman Chemical, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/cb-6644/bio_rxiv__2025__04__21__649771-254-0-1?v=Cayman+Chemical
Average 90 stars, based on 1 article reviews
cb6644 - by Bioz Stars, 2026-07
90/100 stars
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ruvbl1/2 inhibitor cb-6644  (MedKoo Inc)
90
MedKoo Inc ruvbl1/2 inhibitor cb-6644
(A) Hybridization chain reaction (HCR) imaging shows co-localization of ruvbl1 and ruvbl2 transcripts (magenta) with GFPd2 (green). Scale bar, 100 μm. (B) Schematic representation of the Vivo-Morpholino (Vivo-MO) injection strategy in regenerating adult caudal fins. Regenerative growth was quantified at 3 dpa by comparing the injected region (Area I ) to the uninjected control region (Area U ) within the same fin. (C) Representative images of adult fins at 1 dpa (pre-injection) and at 3 dpa following injection with control, ruvbl1 , or ruvbl2 Vivo-MOs at 1 and 2 dpa. Knockdown of ruvbl1 or ruvbl2 resulted in reduced regenerative outgrowth. Scale bar, 0.5 mm. (D) Violin plots showing percent regenerative growth across different conditions (****p<0.0001; **p<0.01). (E) Schematic representation of larval tail regeneration inhibitor treatment strategy. Tails were amputated at 3 dpf and regeneration was monitored in the presence of Ruvbl1/2 inhibitor <t>CB6644</t> from 0 to 4 dpa (3 to 7 dpf). (F) Representative images of regenerating larval tails treated with 1% DMSO (vehicle control) or CB6644 at 10, 25, or 50 μM. Scale bar, 100 μm. (G) Violin plots showing regenerative area (mm 2 ) across treatments (ns, not significant; *p<0.05; ****p<0.0001).
Ruvbl1/2 Inhibitor Cb 6644, supplied by MedKoo Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/cb-6644/pmc10265057-159-1-7?v=MedKoo+Inc
Average 90 stars, based on 1 article reviews
ruvbl1/2 inhibitor cb-6644 - by Bioz Stars, 2026-07
90/100 stars
  Buy from Supplier
cb 6644  (Chemdiv Inc)
86
Chemdiv Inc cb 6644
(A) Hybridization chain reaction (HCR) imaging shows co-localization of ruvbl1 and ruvbl2 transcripts (magenta) with GFPd2 (green). Scale bar, 100 μm. (B) Schematic representation of the Vivo-Morpholino (Vivo-MO) injection strategy in regenerating adult caudal fins. Regenerative growth was quantified at 3 dpa by comparing the injected region (Area I ) to the uninjected control region (Area U ) within the same fin. (C) Representative images of adult fins at 1 dpa (pre-injection) and at 3 dpa following injection with control, ruvbl1 , or ruvbl2 Vivo-MOs at 1 and 2 dpa. Knockdown of ruvbl1 or ruvbl2 resulted in reduced regenerative outgrowth. Scale bar, 0.5 mm. (D) Violin plots showing percent regenerative growth across different conditions (****p<0.0001; **p<0.01). (E) Schematic representation of larval tail regeneration inhibitor treatment strategy. Tails were amputated at 3 dpf and regeneration was monitored in the presence of Ruvbl1/2 inhibitor <t>CB6644</t> from 0 to 4 dpa (3 to 7 dpf). (F) Representative images of regenerating larval tails treated with 1% DMSO (vehicle control) or CB6644 at 10, 25, or 50 μM. Scale bar, 100 μm. (G) Violin plots showing regenerative area (mm 2 ) across treatments (ns, not significant; *p<0.05; ****p<0.0001).
Cb 6644, supplied by Chemdiv Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/cb-6644/pmc09034851-38-27-21?v=Chemdiv+Inc
Average 86 stars, based on 1 article reviews
cb 6644 - by Bioz Stars, 2026-07
86/100 stars
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cb-6644  (MedChemExpress)
N/A
CB-6644 is a selective inhibitor of RUVBL1/2 complex with anti-cancer activity. CB-6644 blocks the ATPase activity of RUVBL1/2 with an IC50 of 15 nM.
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cb-6644  (Biosynth Carbosynth)
N/A
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cb-6644  (Aladdin Scientific Corporation)
N/A
CB-6644 is a selective inhibitor of RUVBL1 / 2 complex with anti-cancer activity. CB-6644 blocks the ATPase activity of RUVBL1/2 with an IC 50 of 15 nM.In VitroCB-6644 (20 µM) interacts with the RUVBL1/2 complex
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cb-6644  (TargetMol)
N/A
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Image Search Results


(A) Hybridization chain reaction (HCR) imaging shows co-localization of ruvbl1 and ruvbl2 transcripts (magenta) with GFPd2 (green). Scale bar, 100 μm. (B) Schematic representation of the Vivo-Morpholino (Vivo-MO) injection strategy in regenerating adult caudal fins. Regenerative growth was quantified at 3 dpa by comparing the injected region (Area I ) to the uninjected control region (Area U ) within the same fin. (C) Representative images of adult fins at 1 dpa (pre-injection) and at 3 dpa following injection with control, ruvbl1 , or ruvbl2 Vivo-MOs at 1 and 2 dpa. Knockdown of ruvbl1 or ruvbl2 resulted in reduced regenerative outgrowth. Scale bar, 0.5 mm. (D) Violin plots showing percent regenerative growth across different conditions (****p<0.0001; **p<0.01). (E) Schematic representation of larval tail regeneration inhibitor treatment strategy. Tails were amputated at 3 dpf and regeneration was monitored in the presence of Ruvbl1/2 inhibitor CB6644 from 0 to 4 dpa (3 to 7 dpf). (F) Representative images of regenerating larval tails treated with 1% DMSO (vehicle control) or CB6644 at 10, 25, or 50 μM. Scale bar, 100 μm. (G) Violin plots showing regenerative area (mm 2 ) across treatments (ns, not significant; *p<0.05; ****p<0.0001).

Journal: bioRxiv

Article Title: Early epigenetic priming of regeneration studied with a novel transgenic epigenetic reporter

doi: 10.1101/2025.04.21.649771

Figure Lengend Snippet: (A) Hybridization chain reaction (HCR) imaging shows co-localization of ruvbl1 and ruvbl2 transcripts (magenta) with GFPd2 (green). Scale bar, 100 μm. (B) Schematic representation of the Vivo-Morpholino (Vivo-MO) injection strategy in regenerating adult caudal fins. Regenerative growth was quantified at 3 dpa by comparing the injected region (Area I ) to the uninjected control region (Area U ) within the same fin. (C) Representative images of adult fins at 1 dpa (pre-injection) and at 3 dpa following injection with control, ruvbl1 , or ruvbl2 Vivo-MOs at 1 and 2 dpa. Knockdown of ruvbl1 or ruvbl2 resulted in reduced regenerative outgrowth. Scale bar, 0.5 mm. (D) Violin plots showing percent regenerative growth across different conditions (****p<0.0001; **p<0.01). (E) Schematic representation of larval tail regeneration inhibitor treatment strategy. Tails were amputated at 3 dpf and regeneration was monitored in the presence of Ruvbl1/2 inhibitor CB6644 from 0 to 4 dpa (3 to 7 dpf). (F) Representative images of regenerating larval tails treated with 1% DMSO (vehicle control) or CB6644 at 10, 25, or 50 μM. Scale bar, 100 μm. (G) Violin plots showing regenerative area (mm 2 ) across treatments (ns, not significant; *p<0.05; ****p<0.0001).

Article Snippet: CB6644 (Cayman Chemical, cat. no. 36125) was dissolved in DMSO to prepare a 10 mM stock concentration and diluted in fish water to a final concentration of 10, 25, and 50 μM, each containing in 1% DMSO.

Techniques: Hybridization, Imaging, Injection, Control, Knockdown