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Boster Bio
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Elabscience Biotechnology
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Proteintech
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OriGene
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BioVendor Instruments
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Image Search Results
Journal: Journal of orthopaedic surgery and research
Article Title: Obacunone acts as a histone deacetylase 1 inhibitor to limit p38MAPK signaling and alleviate osteoarthritis progression.
doi: 10.1186/s13018-025-05804-1
Figure Lengend Snippet: Fig. 1 Obacunone (OB) ameliorates cartilage lesions in rat with ACLT-induced OA. A Safranin O-fast green (Top) and HE staining (Bottom) assays were performed to detect the structural integrity of the articular cartilage in ACLT rats administrated with 2.5, 5, or 10 mg/kg OB. Scale bar = 50 µm. B OARSI score was used to evaluate the articular cartilage based on the results of Safranin O-fast green staining. C The level of COMP in rat serum was measured for the detection of articular cartilage. n = 6. Data were analyzed by one-way ANOVA followed by Tukey’s post hoc test. *P<0.05 and ***P<0.001
Article Snippet: Tissue samples were sliced to 4 μm thickness and stained using a Safranin O and
Techniques: Staining
Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Article Title: A glucuronated flavone TMMG spatially targets chondrocytes to alleviate cartilage degeneration through negative regulation of IL-1β.
doi: 10.1016/j.biopha.2023.114809
Figure Lengend Snippet: Fig. 8. Effect of TMMG administration on Elevated Serum Markers in ACLT Animals. In the serum, (A) pro-inflammatory cytokine IL-1β, (B) Carboxy-terminal telopeptides CTX-II, and (C) COMP (Cartilage oligomeric matrix protein) were elevated in the ACLT-induced osteoarthritis model. These serum bio-markers are diagnostic markers of osteoarthritis. TMMG regulated the levels of these markers in the ACLT group. All values are expressed as mean ± S.E.M. (n = 4–6/group); *P < 0.05, * *P < 0.01, and * **P < 0.001 vs. control group, and #P < 0.05, ##P < 0.01, and ###P < 0.001 vs. ACLT group.
Article Snippet: The TUNEL assay kit (C10618) was purchased from Molecular Probes Life Technologies, Rat Type II collagen Cterminal cross-linked peptide (CTX-II, E-EL-R2554) and
Techniques: Diagnostic Assay, Control